Publications by authors named "Kun-Tao Li"
The study on the mechanism and kinetics of mRNA degradation provides a new vision for chemical intervention on protein expression. The AU enrichment element (ARE) in mRNA 3'-UTR can be recognized and bound by the ARE binding protein (AU-rich Element factor (AUF1) to recruit RNase for degradation. In the present study, we proposed a novel strategy for expression regulation that interferes with the AUF1-RNA binding.
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- Over 85% of lung cancer cases are non-small cell lung cancer (NSCLC), highlighting the need for new treatments focused on this type.
- Mitochondria play a key role in cancer cell energy metabolism, and targeting mitochondrial function is becoming a promising strategy for cancer therapy.
- Researchers developed new carbazole derivatives and found that one specific compound, 5n, effectively disrupted mitochondrial balance, caused cancer cell death, and demonstrated anti-tumor effects in a mice model of NSCLC.