Publications by authors named "Kun-Quan Guo"
Background And Aims: High-density lipoprotein (HDL) might lose atheroprotective functions in the presence of diabetes. We sought to examine associations of HDL cholesterol (HDL-C) and HDL particle (HDL-P) subclasses with risk of coronary heart disease (CHD) stratified by diabetes.
Methods: We included 393,516 participants (20,691 diabetics and 372,825 nondiabetics) from the UK Biobank.
Rationale & Objective: Chronic kidney disease (CKD) leads to lipid and metabolic abnormalities, but a comprehensive investigation of lipids, lipoprotein particles, and circulating metabolites associated with the risk of CKD has been lacking. We examined the associations of nuclear magnetic resonance (NMR)-based metabolomics data with CKD risk in the UK Biobank study.
Study Design: Observational cohort study.
Objective: To prospectively examine the associations of combined lifestyle factors with incident cardiovascular disease (CVD) and mortality in patients with diabetes.
Patients And Methods: Patients with prevalent diabetes were included from 5 prospective, population-based cohorts in China (Dongfeng-Tongji cohort and Kailuan study), the United Kingdom (UK Biobank study), and the United States (National Health and Nutrition Examination Survey and National Institutes of Health-AARP Diet and Health Study). Healthy lifestyle scores were constructed according to non-current smoking, low to moderate alcohol drinking, regular physical activity, healthy diet, and optimal body weight; the healthy level of each lifestyle factor was assigned 1 point, or 0 for otherwise, and the range of the score was 0 to 5.
Article Synopsis
- The study aimed to examine the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels and mortality rates in individuals diagnosed with metabolic dysfunction-associated fatty liver disease (MAFLD) or nonalcoholic fatty liver disease (NAFLD).
- It analyzed data from 4,651 individuals using ultrasonography for FAT and linked mortality data from the National Death Index, finding significant death rates during follow-ups averaging around 26 years.
- Results indicated that higher serum 25(OH)D levels (above 75.0 nmol/L) were associated with lower mortality rates, with a significant nonlinear relationship identified especially in younger adults with MAFLD, suggesting a critical threshold around
Aims/hypothesis: Cancer has contributed to an increasing proportion of diabetes-related deaths, while lifestyle management is the cornerstone of both diabetes care and cancer prevention. We aimed to evaluate the associations of combined healthy lifestyles with total and site-specific cancer risks among individuals with diabetes.
Methods: We included 92,239 individuals with diabetes but without cancer at baseline from five population-based cohorts in the USA (National Health and Nutrition Examination Survey and National Institutes of Health [NIH]-AARP Diet and Health Study), the UK (UK Biobank study) and China (Dongfeng-Tongji cohort and Kailuan study).
Previous meta-analysis studies have indicated inverse associations between some carotenoids and risks of metabolic syndrome, cardiovascular disease, cancer, and all-cause mortality. However, the results for associations between carotenoids and type 2 diabetes (T2D) remain inconsistent and no systematic assessment has been done on this topic. We conducted a systematic review and meta-analysis to examine the associations of dietary intakes and circulating concentrations of carotenoids with risk of T2D.
View Article and Find Full Text PDF[Association of the polymorphism in manganese superoxide dismutase gene with diabetic retinopathy in Chinese type 2 diabetic patients].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
August 2008
Objective: To investigate the association of the polymorphism in manganese superoxide dismutase (Mn-SOD) gene in Chinese type 2 diabetic patients with diabetic retinopathy.
Methods: The Ala(-9)Val polymorphism of the Mn-SOD gene was determined by polymerase chain reaction and direct sequencing in 198 normal control subjects and 264 patients with type 2 diabetes mellitus, among them there were 139 non-diabetic retinopathy (NDR) subjects and 125 subjects with diabetic retinopathy (DR).
Results: There was no statistic difference in the frequencies of VV genotype and V allele between the type 2 diabetic group and the control group.
[Clinical effect of prunrllae oral solution in treating hyperthyrea].
Zhongguo Zhong Yao Za Zhi
August 2007
Objective: To observe the clinical effects of prunrllae oral solution in treating hyperthyrea.
Method: 56 cases with hyperthyrea were randomized into two groups; group A1 was treated by classic method, B1 was treated by classic method combined with prunrllae oral solution. The size, vessel caliber of thyroidea, volume of blood flow and blood flow rate pre-and post-treatment were measured by color supersonic, meanwhile, 20 normal thyroidea were measured as control group.
[Clinical effect of Prunellae Oral Liquid on goiter with different thyroid function].
Zhongguo Zhong Xi Yi Jie He Za Zhi
January 2007
Objective: To observe the clinical effects of Prunellae Oral Liquid (POL) on the size of thyroid with different states of thyroid function in patients of goiter.
Methods: Fifty-six patients with hyperthyroidism, 24 with hypothyroidism and 18 with simple goiter were randomized into two groups. Group A treated by classical therapy, Group B by POL based on classical therapy.