Efficacy and predictive factors of transarterial chemoembolization combined with lenvatinib plus programmed cell death protein-1 inhibition for unresectable hepatocellular carcinoma.

Background: The efficacy and safety of transarterial chemoembolization (TACE) combined with lenvatinib plus programmed cell death protein-1 (PD-1) for unresectable hepatocellular carcinoma (HCC) have rarely been evaluated and it is unknown which factors are related to efficacy.

Aim: To evaluate the efficacy and independent predictive factors of TACE combined with lenvatinib plus PD-1 inhibitors for unresectable HCC.

Methods: This study retrospectively enrolled patients with unresectable HCC who received TACE/lenvatinib/PD-1 treatment between March 2019 and April 2022.

[Effect of on the Biological Functions of Acute B Lymphoblastic Leukemia Cell Line REH].

Objective: To discover the relationship between matrix remodeling associated 7 () and acute B lymphoblastic leukemia (B-ALL), and explore the effect of on the biological functions of B-ALL cell line REH.

Methods: The expression of in blood diseases was searched and analyzed through BloodSpot database. Real-time qPCR was used to detect the expression level of in B-ALL cell line 697 and REH cells.

[The Effect of Matrix Remodeling Associated 7 (MXRA7) Expression on the Biological Function of SHI-1 Cells].

Objective: To express matrix remodeling associated 7 (MXRA7) in the human acute myeloid leukemia SHI-1 cell line and to assess the role of MXRA7 in the biological function of SHI-1 cells.

Methods: The full-length cDNA sequence of human MXRA7 was synthesized and subcloned into the lentivirus shuttle vector pRRL-Venus. SHI-1 cells were transfected with the lentivirus which was packaged with 293T cells.

Effect Of Chinese Herb Danzhi Xiaoyao Pills On Pharmacokinetics Of Venlafaxine In Beagles.

Objective: To investigate the effects of Chinese herb Danzhi Xiaoyao pills on the pharmacokinetics of venlafaxine and its metabolites O-desmethylvenlafaxine (ODV) and N-desmethylvenlafaxine (NDV) in beagles by using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS).

Methods: Six beagles (half male, half female) were chosen to test, being fasted before the experiment but having free access to drinking water 1 day before being fed drugs. After oral administration of venlafaxine hydrochloride tablets (10.

[Comparison of the estrogenic activity of organic compounds in source water and finished water from the Yangtze River and Taihu Lake in certain areas of Jiangsu Province].

A total of 43 source water and finished water samples were collected from the Yangtze River and Taihu Lake in WX and SZ areas of Jiangsu Province from October 2010 to March 2012. The XAD-2 resin was applied to absorb the organic compounds in each water sample respectively. After the procedure of elution, concentration and drying, nonvolatile organic compounds (NVOCs) were obtained.

Optimization of Douchi fibrinolytic enzyme production by statistical experimental methods.

Thrombus disease, one of the common cardiovascular diseases, has attracted worldwide attention for its rising mortality and morbidity. Due to the distinct shortages of current fibrinolytic drugs, new fibrinolytic agents warrant investigation. In this study, 8 fibrinolytic enzyme-producing strains were isolated from Douchi-a traditional Chinese food, and strain XY-1 which produced the largest amount of the enzyme was chosen for the following experiments.