Publications by authors named "Kun-Peng Fang"
Article Synopsis
- The study analyzed the long-term survival of hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT), focusing on the influence of splenomegaly and splenectomy on outcomes after liver resection.
- Out of 716 HCC patients, 140 had splenomegaly, and the study found that splenomegaly was linked to poorer overall and recurrence-free survival compared to those without it.
- Patients who underwent splenectomy for splenomegaly showed significantly better survival rates than those who did not, highlighting the potential benefits of splenectomy in improving long-term outcomes for these patients.
Background: Talin-1 (TLN-1) and TLN-2 are implicated in many cellular processes, but their roles in hepatocellular carcinoma (HCC) remain unclear. This study aimed to assess cell cycle distribution, anoikis, invasion and migration in human HCC MHCC-97 L cells.
Methods: MHCC-97 L cells, which highly express TLN-1, were transduced with TLN-1 shRNA (experimental group) or scramble shRNA (negative control group); non-transduced MHCC-97 L cells were used as blank controls.
Talin-1 correlates with reduced invasion and migration in human hepatocellular carcinoma cells.
Asian Pac J Cancer Prev
January 2015
Background: Talin-1 is a cytoskeleton protein that participates in cell migration and plays a role in tumor formation, migration, and metastasis in different types of cancer. Chinese investigators have observed that the levels of Talin-1 protein and mRNA expression in HCC tissues are significantly lower than in the adjacent non-cancerous tissue. However, Japanese investigators have reported that Talin-1 is upregulated in HCC.
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