Publications by authors named "Kun-Long Duan"
Article Synopsis
- Maintaining the balance of oxidative and reductive processes (redox balance) is crucial for the survival and function of IgA antibody-secreting cells, especially in relation to immune health in the intestine.
- The study identifies the mitochondrial enzyme PCK2 as vital for maintaining this redox balance, with its absence leading to increased cell death and reduced antibody production during colitis.
- Additionally, using the antioxidant Mitoquinone can counteract the negative effects caused by the loss of PCK2 in IgA ASCs, offering a potential new approach for treating colitis.
RNA modifications are essential for the establishment of cellular identity. Although increasing evidence indicates that RNA modifications regulate the innate immune response, their role in monocyte-to-macrophage differentiation and polarisation is unclear. While mA has been widely studied, other RNA modifications, including 5 hmC, remain poorly characterised.
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- * In patients with a type of blood cancer called acute myeloid leukemia (AML), not having enough TET2 seems to disrupt how their bodies process fats.
- * Researchers found that using a common cholesterol-lowering drug called statins can make TET2-deficient cancer cells easier to kill, suggesting a new treatment strategy.
Ferroptosis is triggered by the breakdown of cellular iron-dependent redox homeostasis and the abnormal accumulation of lipid ROS. Cells have evolved defense mechanisms to prevent lipid ROS accumulation and ferroptosis. Using a library of more than 4,000 bioactive compounds, we show that tanshinone from (Danshen) has very potent inhibitory activity against ferroptosis.
View Article and Find Full Text PDFPeroxisomes account for ~35% of total HO generation in mammalian tissues. Peroxisomal ACOX1 (acyl-CoA oxidase 1) is the first and rate-limiting enzyme in fatty acid β-oxidation and a major producer of HO ACOX1 dysfunction is linked to peroxisomal disorders and hepatocarcinogenesis. Here, we show that the deacetylase sirtuin 5 (SIRT5) is present in peroxisomes and that ACOX1 is a physiological substrate of SIRT5.
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