[Research progress on the mechanisms of Tau phosphorylation and its kinases in hypoxic-ischemic brain damage].

Hypoxic-ischemic brain damage (HIBD) is one of the main causes of disability in middle-aged and elderly people, as well as high mortality rates and long-term physical impairments in newborns. The pathological manifestations of HIBD include neuronal damage and loss of myelin sheaths. Tau protein is an important microtubule-associated protein in brain, exists in neurons and oligodendrocytes, and regulates various cellular activities such as cell differentiation and maturation, axonal transport, and maintenance of cellular cytoskeleton structure.

Safety and feasibility of three-dimensional McKeown minimally invasive esophagectomy.

Background: To compare the perioperative outcomes from McKeown minimally invasive esophagectomy (MIE) when performed in three-dimensional versus two-dimensional visualization system, and investigate the learning curve of a single surgeon who implemented three-dimensional McKeown MIE.

Methods: A total of 335 consecutive cases (three-dimensional or two-dimensional) were identified. Perioperative clinical parameters were compared and cumulative sum learning curve was plotted.

Isopropoxy Tetramethyl Dioxaborolane on TiO: Reaction Pathway and Formation of a Visible-Light-Sensitive Photocatalyst.

Borate toxicity is a concern in agriculture since a high level of borates may likely exist in irrigation water systems. In this research, transmission infrared spectroscopy and X-ray photoelectron spectroscopy are employed to study the thermal and photochemical reactions of isopropoxy tetramethyl dioxaborolane (ITDB) on TiO, with the aid of density functional theory calculations. In addition, the possibility for the formation of a boron-modified TiO (B/TiO) surface, using ITDB as the boron source, is explored and the photocatalytic activity of the B/TiO is tested.

A Multicenter Double-blind Phase II Study of Metformin With Gefitinib as First-line Therapy of Locally Advanced Non-Small-cell Lung Cancer.

We present the rationale and study design of the CGMT (combined gefitinib and metformin therapy) trial (www.ClinicalTrials.gov Identifier: NCT01864681), which is aimed at treating locally advanced non-small-cell lung cancer.

Infrared Spectroscopic Study of the Adsorption Forms of Cyanuric Acid and Cyanuric Chloride on TiO2.

Cyanuric acid is often found to be the end product in the hydrolysis of waste melamine and in the TiO2-mediated photocatalytic decomposition of s-triazine-containing compounds used as herbicides or dyes. The photocatalytically recalcitrant nature of cyanuric acid on TiO2 may be closely related to its adsorption properties, including the tautomeric forms present on the surfaces and their bonding structures, which remain to be determined. In this paper, we present the optimized adsorption structures of the four tautomeric isomers (triketo, diketo, monoketo, and triol) of cyanuric acid on a model rutile-TiO2(110) surface and their vibrational absorptions.

Efficacy of recombinant adenoviral human p53 gene in the treatment of lung cancer-mediated pleural effusion.

Pleural effusion induced by lung cancer exerts a negative impact on quality of life and prognosis. The aim of the present study was to evaluate the value of the recombinant adenoviral human p53 gene (rAd-p53) in the local treatment of lung cancer and its synergistic effect with chemotherapy. The present study retrospectively recruited 210 patients with lung cancer-mediated pleural effusion who had adopted a treatment strategy of platinum chemotherapy.

Sequencing and analysis of the transcriptome of the acorn worm Ptychodera flava, an indirect developing hemichordate.

Hemichordates are the sister group of echinoderms, and together they are closely related to chordates within the deuterostome lineage. Therefore, hemichordates represent an important animal group for the understanding of both the evolution of developmental mechanisms in deuterostome animals and the origin of chordates. Recently, the majority of studies investigating hemichordates have focused on the direct-developing enteropneust hemichordate Saccoglossus kowalevskii; few have focused on the indirect-developing hemichordates, partly because of the lack of extensive genomic resources in these animals.

Nanomechanical probing of the septum and surrounding substances on Streptococcus mutans cells and biofilms.

We report a unique bio-nanomechanical behavior at the septum (Z-ring) of Streptococcus mutans-containing biofilm through in situ measurements obtained by atomic force microscopy. A distinct serrated pattern on the releasing force-displacement curves can only be observed with the use of a sharp nanosized probe tip, and this was found at the septum of S. mutans.

Clinical significance of annexin II expression in human non-small cell lung cancer.

The aim of the present study is to explore the role of annexin II in the development and progression of human non-small cell lung cancer (NSCLC). Real-time quantitative reverse transcription-polymerase chain reaction was conducted to detect annexin II mRNA expression. Annexin II protein expression was also determined by western blot.

[Degradation of dimethyl phthalate (DMP) in aqueous solution by UV/Si-FeOOH/H2O2].

In this study the new catalyst Si-FeOOH was synthesized by adding Si to the traditional FeOOH and the mechanic strength of this new catalyst could be enhanced greatly. The photo-degradation of dimethyl phthalate (DMP) by UV/Si-FeOOH/H2O2 was investigated. The new catalyst Si-FeOOH was amorphous structure with high surface area and low soluble iron by XRD, IR and SEM.

Biaryl construction through Kumada coupling with diaryl sulfates as one-by-one electrophiles under mild conditions.

Diaryl sulfates were successfully applied as one-by-one organo electrophiles in Kumada coupling to construct biaryls with the emission of harmless inorganic salts.

Surface reaction limited model for the evaluation of immobilized enzyme on planar surfaces.

Analysis of immobilized enzyme in situ is a crucial step to embed an enzyme onto the planar technology of standard integrated circuit (IC) and microelectromechanical systems (MEMS) for a bioreactor or enzyme-coupled biosensor. A surface reaction limited model, based on a systematized and standardized approach, mathematically derived from mass transfer dynamics and the Michaelis-Menten equation for the measuring the apparent K*(m) (Michaelis-Menten constant) and V*(max) (maximum reaction rate per unit surface area of catalyst) of an immobilized enzyme on a planar surface was developed. The derived equations for the kinetic model were simulated and experimentally confirmed.

[Removal of arsenic (II) by ferrate oxidation-coagulation from drinking water].

Ferrate is multi-function agent in water treatment and shows great oxidizing ability and excellent purifying effect. This experiment evaluated the performance of ferrate for arsenic removal. Experimental results show that the best rate of ferrate and arsenic (III) is 15:1, the efficiency of As removal can be achieved 98%, and the residual concentration of As3 + is < 0.