Publications by authors named "Kun-Lang Wu"
Objectives: This study aimed to identify clinical characteristics to differentiate multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease (KD) in Taiwan, an island with a delayed cluster of MIS-C and a high incidence of KD. Additionally, we studied risk factors for developing severe complications in patients with MIS-C.
Methods: We conducted a retrospective, multicenter, cohort, and observational study that linked data on patients with MIS-C between May and December 2022 and patients with KD between 2019 and 2021 from 12 medical centers.
Effectiveness of two same-manufacturer intravenous immunoglobulin for Kawasaki disease.
J Formos Med Assoc
April 2024
Background: To investigate whether two brands of intravenous immunoglobulin (IVIG) from the same manufacturer lead to varied effects when administered to patients with Kawasaki disease.
(kd) Methods: Clinical characteristics, laboratory data, IVIG response, and coronary arteries change were analyzed between two groups.
Results: We included 158 KD cases.
Background: /Purpose: Reactivity at the Bacillus Calmette-Guérin (BCG) scar is a pathognomonic feature of Kawasaki disease (KD). However, its value in predicting KD outcomes has not been emphasized. This study explored the clinical significance of BCG scar redness with respect to coronary artery outcomes.
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- The study aimed to compare the effectiveness of a technique called slow pathway late activation mapping (SPLAM) and voltage gradient mapping in cryoablation for treating atrioventricular nodal reentry tachycardia (AVNRT).
- It included data from 36 patients treated with SPLAM and 37 patients from a control group, finding that the SPLAM group had significantly fewer cryomapping attempts and ablation applications while achieving 100% acute success rates in both groups.
- With a median follow-up of around 15 months, the recurrence rates were similar between groups, suggesting that SPLAM is an effective method for identifying slow pathway ablation sites, especially in patients with multiple pathways.
Objectives: SARS coronavirus 2 (SARS-CoV-2)-associated multi-system inflammatory syndrome in children indicates that viruses can trigger a Kawasaki disease (KD)-like hyperinflammation. A plausible hypothesis was that coronavirus-specific 'holes' in humoral immunity could cause both diseases.
Methods: To determine whether SARS-CoV-2-naïve patients with KD have inferior humoral immunity for the novel coronavirus, sera of children with KD and control children from year 2015 to 2021 were subjected to ELISA, microwestern, and neutralization assays to evaluate the capabilities in recognizing the receptor-binding domain of SARS-CoV-2, spotting spike proteins of three respiratory syndromic coronaviruses, and blocking SARS-CoV-2 from binding to angiotensin-converting enzyme 2 receptors in vitro, respectively.
Article Synopsis
- The study examines the safety and efficiency of zero fluoroscopy (ZF) guidance for treating left-sided arrhythmia in children compared to traditional fluoroscopic methods.
- It involved 102 patients under 20 years old, with 55 procedures performed using ZF guidance and 49 under fluoroscopic guidance.
- The results showed ZF procedures had significantly shorter fluoroscopy times, similar success rates, and no increase in aortic valve issues over a six-month follow-up period, confirming ZF as a safe approach post a learning curve of about 20 cases.
Background: Zero fluoroscopy during ablation of arrhythmias has been introduced to reduce radiation exposure. However, the safety, feasibility and efficacy of the technique in pediatric populations have yet to be delineated.
Objectives: To investigate the safety, feasibility and effectiveness of zero fluoroscopic-guided transcatheter ablation of right-sided supraventricular tachycardia substrates in a pediatric population.
Background: Cryoablation is an alternative treatment for atrioventricular nodal reentrant tachycardia (AVNRT) and right anteroseptal and midseptal accessory pathways (APs) with a low complication rate. A high recurrence rate is still a concern in pediatric patients.
Methods: From February 2015 to March 2017, all consecutive patients who underwent cryoablation for supraventricular tachycardia were included in this study.
Objective: To delineate the outcome of ventricular tachycardia (VT) in the paediatric population.
Methods: Patients who developed sustained VT between the ages of 0 and 18 years in a referral centre from 1991 to 2015 were enrolled.
Results: A total of 116 patients (67 male/49 female) had documented VT, and 53 (46%) had associated heart disease, namely cardiomyopathy in 20 (17%), structural heart disease in 19 (16%) and channelopathy in 14 (12%), and some of them presented with two types of associated heart disease.
Background: Idiopathic ventricular tachycardia (VT) is an important pediatric arrhythmia but relevant studies in Asian cohort are rare. We determined the electrophysiological characteristics and outcomes of this rhythm disturbance.
Methods: From an institutional database, patients aged <18years without structural heart disease who have sustained monomorphic VT (longer than 30s) during 1995-2016 were enrolled.
Background: Supraventricular tachycardia (SVT) is common in complex congenital heart disease (CCHD) patients with single-ventricle physiology and may cause hemodynamic deterioration. We reported the outcomes of catheter ablation for such complex SVT in these single-ventricle CCHD patients.
Methods And Results: Patients with single-ventricle physiology (defined as CCHD patients) who received electrophysiology studies and catheter ablation between 1995 and 2015 were studied.
Background: The arterial switch operation (ASO) may be infeasible in patients with transposition of the great arteries (TGA) and left ventricular outflow tract obstruction (LVOTO).
Methods And Results: Patients with LVOTO were identified among the 229 patients with TGA repaired between 1991 and 2006. Dynamic LVOTO was defined as LVOTO without LVOT abnormalities requiring resection (group I, receiving ASO).
Background: Pediatric patients paced for complete atrioventricular block (CAVB) are at risk of developing dilated cardiomyopathy (DCM). We sought to explore the role played by the setting of ventricular pacing.
Methods And Results: A total of 35 patients <18 years of age at diagnosis were enrolled.
Arterial switch operation (ASO) is considered the procedure of choice for transposition of great arteries (TGA). The results and long-term prognosis improved with recent advances in perioperative management. We herein analyze the clinical outcome of patients undergoing ASO at our institution during the past 3 years.
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