Publications by authors named "Kun-Goung Lai"
Article Synopsis
- Folic acid acts as a vital micronutrient that regulates redox balance, particularly in liver cancer cells, by influencing key cellular processes related to oxidative stress.
- A deficiency in folate leads to decreased levels of important anti-apoptotic proteins like survivin and glucose-regulated protein-78, which play a role in managing reactive oxygen species.
- Folic acid deficiency also triggers endoplasmic reticulum stress, which affects glutathione levels and impairs crucial enzymes necessary for maintaining cellular redox balance, suggesting that folate is essential for countering oxidative damage.*
Cisplatin is commonly recognized as a DNA-damaging drug; however, its versatile antitumor effects have been demonstrated to extend beyond this narrow functional attribute. The present study determined how cisplatin regulates alternative pathways and transcription factors to exert its additional antitumor actions. Cisplatin was observed to be able to trigger an endoplasmic reticulum stress response through aggravated nitrosative stress coupled to perturbed mitochondrial calcium (Ca) homeostasis, which substantially downregulated glucose-regulated protein (GRP) 78 expression by suppressing the cleavage of activating transcription factor (ATF) 6α (90 kDa) to its active 50 kDa subunit.
View Article and Find Full Text PDFAims: This study delineated the mechanisms of paclitaxel (PTX) assistance in overcoming radioresistance in hepatoma and human lung adenocarcinoma (HLAC) cells.
Main Methods: The TUNEL assay was used as an index of radiosensitivity, and the MTT assay assessed the efficacy of various combined PTX/RT treatments. The efficacy of PTX disruptions of hypoxia-inducible factor-1 alpha (HIF-1α) was assessed using Western blotting.