Targeting 4-1BB for tumor immunotherapy from bench to bedside.

Immune dysfunction has been proposed as a factor that may contribute to disease progression. Emerging evidence suggests that immunotherapy aims to abolish cancer progression by modulating the balance of the tumor microenvironment. 4-1BB (also known as CD137 and TNFRS9), a member of tumor necrosis factor receptor superfamily, has been validated as an extremely attractive and promising target for immunotherapy due to the upregulated expression in the tumor environment and its involvement in tumor progression.

[Strip nail internal fixation with bone graft for the treatment of tibial plateau fracture].

Objective: To investigate surgical outcomes of strip nail internal fixation with bone graft in treating tibial plateau fracture.

Methods: From May 2012 to May 2014,36 patients with tibial plateau fracture were retrospectively analyzed, including 25 males and 11 females with an average age of 43.5 (ranged from 17 to 65) years old.

[Frequency correction in terahertz absorption spectroscopy].

Measurement errors in frequency domain always appear when testing samples' terahertz (THz) absorption spectrum using terahertz time-domain spectroscopy (THz-TDS) system, which is supposed to be attributed to the sampling accuracy of the high speed electro-optic sampling system In order to make the measurement have a high accuracy, the method of error correction was studied in the present article. Carbon monoxide in gas phase was employed as our standard sample, and its absorption spectrum at the pressure of 2.0 x 10(5) Pa was measured experimentally.