Publications by authors named "Kun-Dong Zhang"
Article Synopsis
- The text references a correction made to an article found on page 1709 of volume 13.
- The correction is associated with the publication identified by PMID: 34853645.
- It indicates that there was an error in the original article that has now been addressed.
Pancreatic ductal adenocarcinoma (PDAC) is currently one of the most lethal cancers worldwide. Several basic studies have confirmed that Kirsten rat sarcoma virus (KRAS) is a key driver gene for the occurrence of PDAC, and KRAS mutations have also been found in most patients in clinical studies. In this study, two pan-KRAS inhibitors, BI-2852 and BAY-293, were chosen as chemical probes to investigate their antitumor potency in PDAC.
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- Pancreatic cancer (PC) is highly lethal, and previous research has struggled to pinpoint key genes that control the proliferation of PC cells.
- The study aims to delve into the role of the CBX8/IRS1/AKT pathway in promoting PC cell growth and survival.
- Results show that CBX8 is upregulated in PC tissues, linked to poorer patient outcomes, and may serve as a potential target for new treatments, as it activates the PI3K/AKT signaling pathway through IRS1, modulated by HIF-1α.
This study sought to perform integrative analysis of the immune/methylation/autophagy landscape on breast cancer prognosis and single-cell genotypes. Breast Cancer Recurrence Risk Score (BCRRS) and Breast Cancer Prognostic Risk Score (BCPRS) were determined based on 6 prognostic IMAAGs obtained from the TCGA-BRCA cohort. BCRRS and BCPRS, respectively, were used to construct a risk prediction model of overall survival and progression-free survival.
View Article and Find Full Text PDFBackground: Pancreatic cancer (PC) is one of the deadliest cancers worldwide. PC metastasis involves a complex set of events, including epithelial-mesenchymal transition (EMT), that increase tumor cell invasiveness. Recent evidence has shown that hypoxia is a major EMT regulator in pancreatic cancer cells and facilitates metastasis; however, the mechanisms remain elusive.
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