ZEB2 signaling is essential for ureteral smooth muscle cell differentiation and maintenance.

Unlabelled: Mowat-Wilson Syndrome (MWS) is a multiple congenital anomaly syndrome caused by mutations in the which plays a critical role in cell fate determination and differentiation during development. Congenital anomalies of the kidney and urinary tract (CAKUT) have been reported in MWS patients. However, the role of ZEB2 in urinary tract development and the cellular and molecular mechanism underlining the CAKUT phenotypes in MWS remains unknown.

Highly Flexible and Ultralight PVA-co-PE-AgNW/MXene Composite Film with Low Filling for Multistage Electromagnetic Interference Shielding.

A composite film with multistage mechanisms for effective electromagnetic interference (EMI) shielding in the ultra-wide frequency of 8-20 GHz was designed. Poly(vinyl alcohol-co-ethylene) (PVA-co-PE) nanofibers and twill-structured nylon 6 fabric are used as substrate and filter film, respectively. Subsequently, a PVA-co-PE/silver nanowire (AgNW)/MXene (PVA/Ag/M) composite film is prepared by vacuum filtration, templating, and hot-pressing.

Multiscale Porous Heat Insulation Polypropylene Foam with High Infrared Absorption Performance.

Polypropylene (PP) foam is a potential high-temperature insulating porous material with high mechanical properties and service temperature. However, the development of insulating and multifunctional foams based on PP still faces challenges. In this study, grafting by ultraviolet (UV) radiation was successfully used to introduce ester-based groups into PP molecular chains.

Giant Tunneling Magnetoresistance Based on Spin-Valley-Mismatched Ferromagnetic Metals.

Half metals, which are amenable to perfect spin filtering, can be utilized for high-magnetoresistive devices. However, available half metals are very limited. Here, we demonstrate that materials with intrinsic spin-valley-mismatched (SVM) states can be used to block charge transport, resembling half metals and leading to giant tunneling magnetoresistance.

Exactly Solvable Mobility Edges for Phonons in One-Dimensional Quasiperiodic Chains.

Mobility edges, which demarcate the boundary between extended and localized states, are fundamental to understanding the physics of localization in condensed matter systems. Systems exhibiting exact mobility edges are rare, and the localization properties of phonons have received limited prior investigation. In this work, we reveal analytical mobility edges in one-dimensional quasiperiodic-modulated spring-mass chains.

Prediction model and real-time diagnostics of hydraulic fracturing pressure for highly deviated wells in deep oil and gas reservoirs.

It is a common occurrence in the fracture processes of deep carbonate reservoirs that the fracturing construction pressure during hydraulic fracturing operation exceeds 80 MPa. The maximum pumping pressure is determined by the rated pressure of the pumping pipe equipment and the reservoir characteristics, which confine the fracture to the target area. When the pump pressure exceeds the safety limit, hydraulic fracturing has to reduce the construction displacement to prevent potential accidents caused by overpressure.

Community assembly and succession of the functional membrane biofilm in the anammox dynamic membrane bioreactor: Deterministic assembly of anammox bacteria.

The anammox dynamic membrane bioreactor (DMBR) exhibits potential for efficient nitrogen removal via anammox processes. The functional membrane biofilm in the anammox DMBR significantly enhances nitrogen removal, ensuring robust operation. Nevertheless, ecological mechanisms underpinning the nitrogen removal function of the membrane biofilm remain unclear.

Using network pharmacology and molecular docking technology, proteomics and experiments were used to verify the effect of Yigu decoction (YGD) on the expression of key genes in osteoporotic mice.

Background: Yigu decoction (YGD) is a traditional Chinese medicine prescription for the treatment of osteoporosis, although many clinical studies have confirmed its anti-OP effect, but the specific mechanism is still not completely clear.

Methods: In this study, through the methods of network pharmacology and molecular docking, the material basis and action target of YGD in preventing and treating OP were analyzed, and the potential target and mechanism of YGD in preventing and treating OP were clarified by TMT quantitative protein and experiment.

Results: Network pharmacology and molecular docking revealed that the active components of YGD were mainly stigmasterol and flavonoids.

Development and validation of a real-time prediction model for acute kidney injury in hospitalized patients.

Early prediction of acute kidney injury (AKI) may provide a crucial opportunity for AKI prevention. To date, no prediction model targeting AKI among general hospitalized patients in developing countries has been published. Here we show a simple, real-time, interpretable AKI prediction model for general hospitalized patients developed from a large tertiary hospital in China, which has been validated across five independent, geographically distinct, different tiered hospitals.

Microbial Biotic Associations Dominated Adaptability Differences of Dioecious Poplar Under Salt Stress.

How different stress responses by male and female plants are influenced by interactions with rhizosphere microbes remains unclear. In this study, we employed poplar as a dioecious model plant and quantified biotic associations between microorganisms to explore the relationship between microbial associations and plant adaptation. We propose a health index (HI) to comprehensively characterize the physiological characteristics and adaptive capacity of plants under stress.

Development of Conductive Antibacterial Coatings on Cotton Fabrics via Polyphenol-Mediated Silver Mirror Reaction.

Herein, this study reports the development of a multifunctional conductive antibacterial cotton fabric through the utilization of the natural polyphenol-mediated silver mirror reaction. The experimental results demonstrate that polyphenols can effectively facilitate the deposition of silver nanoparticles (AgNPs), resulting in a uniform and durable hybrid nanocoating on the cotton fabric. The effects of polyphenol's molecular weights on the coating structures and stabilities have been revealed via two distinct approaches: washing resistance and electrochemical testing systems.

Identification of potential pathogenic genes for urolithiasis through multi-omics Mendelian randomization analysis.

Urolithiasis, a common urological disorder affecting about 10% of the global population, is known for its high recurrence rate, yet its genetic mechanisms remain poorly understood. This study aimed to fill this gap by identifying potential pathogenic genes associated with urolithiasis using a multi-omics Mendelian randomization approach. We conducted a comprehensive analysis that integrated genome-wide association studies (GWAS), expression quantitative trait loci (eQTL), methylation quantitative trait loci (mQTL), and protein quantitative trait loci (pQTL) data.

NC@BiS Nanospheres as High-Performance Anode Materials for Lithium-Ion Batteries.

BiS holds immense potential to be promoted as an anode material for lithium-ion batteries (LIBs), owing to the high theoretical gravimetric and volumetric capacities. However, the poor electrical conductivity and volume expansion during cycling hinder the practical applications of BiS. Therefore, through subsequent heat treatment, the nitrogen-doped carbon film was successfully loaded on the nanosphere BiS, which we call nitrogen-rich carbon layer-coated BiS (NC@BiS).

Prospective analysis of the effects of mutation on local tumor progression and overall survival after radiofrequency ablation for colorectal liver metastases.

Objectives: To investigate the effects of mutation on local tumor progression (LTP) and overall survival (OS) after radiofrequency ablation (RFA) for colorectal liver metastases (CRLMs).

Methods: This prospective study consecutively enrolled patients with CRLM who underwent ultrasound-guided RFA between June 2020 and July 2022. mutation status was analyzed via the amplification refractory mutation system PCR method.

Nutritional supplementation during tuberculosis treatment to improve clinical symptoms: a double-blinded placebo-controlled randomized trial.

Undernutrition coexists with tuberculosis and is associated with adverse treatment outcomes. Nutrition packages have been incorporated into tuberculosis patient care in some regions but there are little data on its effectiveness. The aim of this study is to evaluate the effect of a nutrition package on the treatment response and nutritional status of tuberculosis patients.

ALOPECIA AREATA PROFILING SHOWS LNCRNAS REGULATE THE SUPPRESSED EXPRESSION OF KERATIN.

Background: Alopecia areata (AA) is one of the most common autoimmune hair diseases. Long non-coding RNAs (lncRNAs) have been shown to be involved in the pathophysiological progression of a variety of diseases; however, how lncRNAs are involved in the pathogenesis of alopecia areata is not fully understood.

Objective: In order to study the differential expression profiles of mRNA and lncRNA in patients with alopecia areata and provide experimental basis for the diagnosis and treatment of alopecia areata.

Yigu decoction regulates plasma miRNA in postmenopausal osteoporosis patients: a randomized controlled trial.

Background: Postmenopausal osteoporosis (PMOP) is a serious condition that affects elderly individuals. Our previous study revealed that Yigu decoction (YGD) effectively improved bone mineral density (BMD) in elderly individuals, but the mechanism underlying this effect remains unclear. In this study, we investigated the relationships among YGD, microRNAs (miRNAs), and bone metabolism by assessing the effects of YGD on the miRNA levels in patient plasma to provide a scientific basis for treating PMOP with YGD.

Effects of vertical forest stratification on precipitation material redistribution and ecosystem health of Pinus massoniana in the Three Gorges Reservoir area of China.

Vertical stratification of forest plays important roles in the local material balance and in maintaining forest health by distributing and redistributing precipitation materials through adsorption, fixation, and release. Differences in runoff nutrient concentrations among vertical layers are closely related to vertical stratification (factors such as the trunk, canopy, forest litter, and soil physical and chemical properties). Long-term forest observations revealed significant spatial differences in Pinus massoniana (Pinus massoniana Lamb.

Synergistic Effects of Polydopamine/Medical Stone Bio-Adsorbents for Enhanced Interfacial Adsorption and Dynamic Filtration of Bacteria.

Polymer-based wastewater disinfection, which is typically performed using chemical oxidation or irradiation, can result in various toxic byproducts and corrosion under harsh environments. This study introduces a robust bio-adsorbent prepared from naturally abundant polydopamine-modified medical stone (MS@PDA) for the high-efficiency removal of bacteria from water. The PDA nanocoating can be easily applied through an in situ self-polymerization process, resulting in a considerably high bacterial adsorption capacity of 6.

Classification of Neoadjuvant Therapy Response in Patients With Colorectal Liver Metastases Using Contrast-Enhanced Ultrasound-With Histological Pathology as the Gold Standard.

Objective: To evaluate the response to neoadjuvant therapy in patients with colorectal liver metastases (CRLMs) using ultrasound(US) and contrast-enhanced ultrasound(CEUS), with correction to the tumor regression grade (TRG) of pathological results.

Methods: This study included patients with resectable CRLMs admitted from February to December 2022. After at least 4 cycles neoadjuvant therapy, all the patients received US and CEUS examinations within two weeks before hepatectomy.

Early cancer screening surveillance in one medical center of China.

Objectives: Cancer screening aims to detect and treat malignant lesions at an early stage and to prolong patients' lifetime. There is still a lack of effective cancer screening programs in China. We initiated a screening project in 2018 and this study presented the cancer screening status in China.

Leveraging cell death patterns to predict metastasis in prostate adenocarcinoma and targeting PTGDS for tumor suppression.

Metastasis is the major cause of treatment failure in patients with prostate adenocarcinoma (PRAD). Diverse programmed cell death (PCD) patterns play an important role in tumor metastasis and hold promise as predictive indicators for PRAD metastasis. Using the LASSO Cox regression method, we developed PCD score (PCDS) based on differentially expressed genes (DEGs) associated with PCD.