Publications by authors named "Kun Song"

Ovarian cancer is a highly lethal gynecological malignancy with common platinum resistance. Lactylation is involved in multiple biological processes. Thus, we explored the role of histone and non-histone lactylation in platinum resistance, providing a potential therapeutic target to overcome platinum resistance in ovarian cancer.

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STING is an essential component of the innate immune system, yet homeostatic STING expression patterns and regulation are unknown. Using reporter and conditional transgenic mice, we found that regulation of STING expression is critical for immune cell development and functionality. STING expression was repressed in neutrophils, and forced STING expression or signaling drove systemic inflammatory disease.

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Cervical cancer remains a major public health challenge worldwide, despite being largely preventable through effective interventions. Timely evidence regarding the global landscape of cervical cancer is crucial for measuring the magnitude of inequalities and monitoring progress towards cervical cancer elimination. We aimed to provide an updated overview of the global burden of cervical cancer using the GLOBOCAN 2022 database.

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Introduction: We reviewed a 7-year experience (Jan 2016 to Oct 2023) in diagnosing and surgically treating Acquired Rectovestibular Fistula (ARVF). Our study describes the medical history, introduces new classifications based on fistula features, and outlines the application of diverse surgical techniques in treating these patients.

Methods: A total of 78 girls with ARVF appeared asymptomatic at birth.

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The 2',5'-oligoadenylate synthetase (OAS)-RNase L pathway is a classical antiviral innate immune pathway. Upon sensing dsRNA, OAS produces 2',5'-oligoadenylate (2-5A) as a second messenger to activate RNase L. Whether 2-5A can be transported to extend the reach of innate immune signaling has not been established.

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Hematopoietic progenitor kinase 1 (HPK1) is a negative regulator of the T cell receptor signaling pathway and is therefore a target of interest for immunooncology. Nonselective HPK1 inhibitors may affect other kinase components of T cell activation, blunting the beneficial impact of enhanced T cell activity that results from HPK1 inhibition itself. Here, we report the discovery of pyrazine carboxamide HPK1 inhibitors and their optimization through structure-based drug design to afford a highly selective HPK1 inhibitor, compound (AZ3246).

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The secure storage and transmission of information are core measures that ensure data security. Within intricate information landscapes, reconfigurable encryption mechanisms serve as robust defenses against potential breaches of encrypted data. Here, we propose a reconfigurable visual secret sharing (VSS) encryption strategy that leverages the capabilities of optical metasurfaces and exhibits a dual-channel secondary encryption scheme.

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 This retrospective study aimed to explore the prognostic effect of cumulative score based on neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and fibrinogen in older adults diagnosed with glioblastoma (GBM).  Retrospective study.  Huashan Hospital.

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Background: Identifying past, present, and future temporal trends in gallbladder and biliary tract cancer (GBTC) can increase public awareness and promote changes in prevention and treatment strategies.

Methods: The incidence and death rates of GBTC between 1990 and 2021 were extracted from the Global Burden of Disease study 2021 and assessed according to country, region, year, age, and sex. Time trends were measured using the average annual percentage change (AAPC) and projections of the burden of disease for 2022 to 2045 were made using the Bayesian age-period-cohort model.

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Optogenetics is a valuable tool for studying the mechanisms of neurological diseases and is now being developed for therapeutic applications. In rodents and macaques, improved channelrhodopsins have been applied to achieve transcranial optogenetic stimulation. While transcranial photoexcitation of neurons has been achieved, noninvasive optogenetic inhibition for treating hyperexcitability-induced neurological disorders has remained elusive.

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Urbanization greatly impacts both the diversity of soil seed banks and the spatial dynamics of species. These seed banks serve as a window into the ecological history and potential for recovery in urban wastelands, which are continually evolving due to urbanization. In this study, we selected 24 plots along urban-rural gradients in Shanghai, China.

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Background: There is lack of predictive models for the risk of severe complications during hospitalization in patients with acute myocardial infarction (AMI). In this study, we aimed to create a nomogram to forecast the likelihood of in-hospital severe complications in AMI.

Methods: From August 2020 to January 2023, 1024 patients with AMI including the modeling group (n=717) and the validation group (n=307) admitted in Changsha Central Hospital's emergency department.

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Background: Progress in immunotherapy for pancreatic ductal adenocarcinoma (PDAC) has been slow, yet the relationship between microorganisms and metabolites is crucial to PDAC development. This study compares the biliary microbiota and metabolomic profiles of PDAC patients with those of benign pancreatic disease patients to investigate PDAC pathogenesis and its relationship with immunotherapy.

Methods: A total of 27 patients were recruited, including 15 diagnosed with PDAC and 12 with benign pancreaticobiliary conditions, all of whom underwent surgical treatment.

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Background: Common side effect of Herpes Zoster, postherpetic neuralgia (PHN), causes persistent pain that seriously affects quality of life. Lack of dependable biomarkers makes the clinical diagnosis and treatment of PHN difficult, so complicating the assessment of therapeutic efficacy. Blood metabolites are becoming more and more well known as significant disease markers.

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Objectives: Many studies have explored the association between handgrip strength and metabolic syndrome; however, the findings are inconsistent due to the different types of indicators used to assess handgrip strength (absolute vs. relative handgrip strength). This prospective cohort study aimed to simultaneously investigate the associations of both absolute and relative handgrip strength with metabolic syndrome, and to compare the predictive abilities of these two measures among Chinese adults.

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Article Synopsis
  • Human coronaviruses can cause a range of symptoms, from mild colds to severe respiratory issues, but the mechanisms by which they promote inflammation during infection are not fully understood.
  • The study highlights the role of coronavirus nonstructural protein 14 (NSP14) in manipulating the host's immune response by activating NF-κB through the linear ubiquitin chain assembly complex (LUBAC).
  • Specifically, the interaction between NSP14 and HOIL-1-interacting protein (HOIP) leads to the recruitment of NF-κB signaling components, resulting in increased proinflammatory factor expression while inhibiting type I interferon responses, thereby contributing to a skewed inflammatory response.
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  • Understanding the phenotypes and endotypes of atopic dermatitis (AD) is crucial for creating tailored treatments, and recent research highlights the connection between gut health and skin conditions.
  • The study analyzed data from a large cohort of children to identify five distinct AD phenotypes and their risk factors, particularly focusing on the early-onset persistent and late-onset types.
  • Multiomics analyses revealed specific gut microbiome and metabolic characteristics associated with these phenotypes, suggesting that early-life gut health may influence the development and severity of AD in children.
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The current techniques for coloring surfaces using lasers necessitate the identification of numerous laser marking parameters, which is a laborious process. Furthermore, the quantitative analysis of generating a wide variety of colors through fewer sets of laser marking parameters is a huge challenge. This work employs a nanosecond laser to generate mixed structural colors from micro-nano structures on the surface of stainless steel in order to address these issues.

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  • Alzheimer's disease (AD) is a common neurodegenerative disorder with no cure, making early detection and risk gene identification essential for effective treatment.
  • Our research analyzed three datasets from the hippocampus of 37 AD patients and 66 healthy controls, revealing 25 up-regulated and 291 down-regulated genes, particularly those related to synaptic transmission.
  • Through a Cox model using nine identified genes, we demonstrated their potential for assessing AD risk, offering valuable insights for early detection and future treatment strategies.
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Stimulator of interferon genes (STING) is an endoplasmic reticulum (ER) protein that plays a crucial role in cytosolic DNA-mediated innate immunity. Both STING agonists and antagonists have demonstrated their ability to enhance mouse survival against coronavirus, however, the physiological role of endogenous STING in coronavirus infection remains unclear. Our research unveils that STING inhibits coronavirus replication by impeding the formation of the ER-derived double-membrane vesicles (DMVs), the organelles in which coronavirus replicates.

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  • Engineered extracellular vesicles (EVs) are gaining attention as therapeutics for gene and cell therapy, but current methods struggle with producing high-quality EVs and precise control over their therapeutic delivery.
  • The PURE nanoplatform facilitates efficient electro-transfection, improving EV production while maintaining a suitable extracellular environment, achieving significantly higher yields and therapeutic content compared to natural EVs.
  • The effectiveness of PURE-engineered miR-130a-EVs was demonstrated by enhancing ovary function in aged mice, showcasing its potential for clinical applications in EV-mediated therapies.
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  • Engineering electronic band structures through doping is essential for enhancing thermoelectric performance in materials.
  • The study reveals that the Sn-s states in SnTe significantly impact the density of states at the valence band's top, influencing band structure tuning.
  • A design approach is presented, identifying Al as an effective dopant that, combined with Sb and AgBiTe, leads to a record high average ZT of 1.15 across a temperature range of 300 to 873 K.
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Article Synopsis
  • * In this phase 3, double-blind trial, 445 women were randomly assigned to receive either cadonilimab with chemotherapy or a placebo with chemotherapy, with results measured over time for progression-free and overall survival.
  • * Findings showed that patients receiving cadonilimab experienced a median progression-free survival of 12.7 months compared to 8.1 months for the placebo group, along with improved overall survival,
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Metasurfaces provide an unprecedented platform for precise and subwavelength-scale modulation of optical phases, leading to innovative advancements in wavefront shaping and holography devices. This study presents a single-layer umbrella-like metasurface capable of multichannel holography, encoded with both polarization and wavelength. By leveraging a unique chiral-assisted strategy, we achieve simultaneous decoupling of wavelength and spin states through single-parameter modulation.

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