Publications by authors named "Kun Qin"

Purpose: To study the correlation between the levels of inflammatory factors in gingival crevicular fluid and implant stability and prognosis after oral implant restoration.

Methods: A total of 78 patients who underwent oral implant restoration surgery from August 2022 to August 2023 were selected as the experimental group. According to the results of X-ray examination 1 month after implantation, the patients were divided into poor prognosis subgroup(n=33) and good prognosis subgroup(n=45), another 60 healthy subjects who underwent physical examination during the same period were selected as the control group.

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Aging-related lipid metabolic disorder is related to oxidative stress. Selenium (Se)-enriched Cardamine violifolia (SEC) is known for its excellent antioxidant function. The objective of this study was to evaluate the effects of SEC on antioxidant capacity and lipid metabolism in the liver of aged laying hens.

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  • - A new species of leaf litter toad has been identified in Dayaoshan National Nature Reserve, Guangxi, China, using genetic, physical, and sound analysis.
  • - Key distinguishing features include medium size, rough dorsal skin, black spots on flanks, and specific throat and ventral surface colors, among others.
  • - This toad breeds between March and April in evergreen forests at elevations of 1,000 to 1,600 meters.
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Background: Response to pharmacotherapy varies considerably among youths with bipolar disorder (BD) and is poorly predicted by clinical or demographic features. It can take several weeks to determine whether medication for BD is clinically effective. Although neuroimaging biomarkers are promising predictors, few studies examined the predictive value of the brain connectomic topology.

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As globalization and economic development accelerate, Chinese tea has emerged as an essential export commodity in the international market. China boasts abundant tea resources, which have significantly promoted economic growth through tea exports. This study analyses the relevant literature and the prevailing state of China's tea export trade.

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  • The study investigates immune checkpoint inhibitor (ICI)-induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), aiming to identify unique clinical features and mechanisms compared to non-ICI-induced cases.
  • It analyzed 41 ICI-induced SJS/TEN cases against 107 non-ICI cases, revealing ICI cases often have a longer latency period, a smaller body surface area affected, and less severe mucositis.
  • The research suggests that PD-1 inhibitors are primarily responsible for these reactions, with a mortality rate of 24.5%, offering insights into treatment approaches and the underlying immune mechanisms involved.
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  • Enteroviruses, including polioviruses and non-polio variants, are a significant health concern, with over 116 types affecting humans annually.
  • A novel peptide called P25 from EV-D68 shows broad antiviral activity against multiple enterovirus species by targeting key viral structures and functions.
  • P25 has the potential to serve as a universal anti-enterovirus drug candidate due to its ability to block viral receptor binding, inhibit viral genome release, and reduce the production of infectious viral particles.
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Background: While patients with major depressive disorder (MDD) and bipolar disorder (BD) exhibited default mode network (DMN) dysfunction revealed by aberrant resting-state functional connectivity (rsFC) patterns, previous findings have been inconsistent. Little is known about the similarities and differences in DMN rsFC between MDD and BD.

Methods: A voxel-wise meta-analysis of seed-based DMN rsFC studies on MDD or BD was performed using the Seed-based d Mapping software with permutation of subject images (SDM-PSI).

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Enteroviruses (EVs and RVs) are prevalent worldwide and cause various diseases in humans, of which the VP1-pocket is a target of antivirals, with a lipid molecule as a pocket factor to stabilize the virion. However, the characterization of the structure of the VP1-pocket in EVs is poor. Here, we compared the published capsid crystals of EVs and RVs and proposed a structural framework for the VP1-pocket: Frame 1-4, which is located at the CD loop, GH loop, and C-terminus, presenting with an outward opening appearance or not.

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Major depressive disorder (MDD) is a heterogeneous clinical syndrome with widespread subtle neuroanatomical correlates. Our objective was to identify the neuroanatomical dimensions that characterize MDD and predict treatment response to selective serotonin reuptake inhibitor (SSRI) antidepressants or placebo. In the COORDINATE-MDD consortium, raw MRI data were shared from international samples ( = 1,384) of medication-free individuals with first-episode and recurrent MDD ( = 685) in a current depressive episode of at least moderate severity, but not treatment-resistant depression, as well as healthy controls ( = 699).

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Background: Self-body satisfaction is considered a psychological factor for exercise dependence (EXD). However, the potential neuropsychological mechanisms underlying this association remain unclear.

Purpose: To investigate the role of white matter microstructure in the association between body satisfaction and EXD.

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A yellow pigmented, Gram-stain-positive, motile, facultatively anaerobic and irregular rod-shaped bacteria (strain M0-14) was isolated from a till sample collected from the foreland of a high Arctic glacier near the settlement of Ny-Ålesund in the Svalbard Archipelago, Norway. Phylogenetic analysis based on 16S rRNA gene sequence comparisons revealed that M0-14 formed a lineage within the family , suborder . M0-14 represented a novel member of the genus and had highest 16S rRNA gene sequence similarity to LRZ-2 (97.

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  • A new species of the Asteraceae family has been identified in Dayaoshan National Nature Reserve, Guangxi province, China, and it's described with illustrations.
  • This species is found in rock crevices of mountain valleys and has been confirmed as part of its genus through phylogenetic analysis using ITS sequences and plastome data.
  • It can be differentiated from a similar species based on specific traits such as bract indumentum, flower color, corolla length, bract stalk presence, and geographic distribution.
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Background: Major depressive disorder (MDD) has been increasingly understood as a disruption of brain connectome. Investigating grey matter structural networks with a large sample size can provide valuable insights into the structural basis of network-level neuropathological underpinnings of MDD.

Aims: Using a multisite MRI data-set including nearly 2000 individuals, this study aimed to identify robust topology and connectivity abnormalities of grey matter structural network linked to MDD and relevant clinical phenotypes.

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Oxidative stress occurs in the process of egg storage. Antioxidants as feed additives can enhance egg quality and extend the shelf life of eggs. Selenium-enriched (SEC) has strongly antioxidant properties.

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A new species of odorous frog, , was found at the Damingshan National Nature Reserve in Guangxi, China. This species can be distinguished from its congeners by a combination of the following characters: medium body size (SVL 52.3-54.

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Severe mental health problems with the representation of negative affect symptoms (NAS) have been increasingly reported during the coronavirus disease 2019 (COVID-19) pandemic. This study aimed to explore the multivariate patterns of brain functional connectome predicting COVID-19-related NAS. This cohort study encompassed a group of university students to undergo neuroimaging scans before the pandemic, and we re-contacted participants for 1-year follow-up COVID-related NAS evaluations during the pandemic.

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Background: Youth with a family history of bipolar disorder (BD) may be at increased risk for mood disorders and for developing side effects after antidepressant exposure. The neurobiological basis of these risks remains poorly understood. We aimed to identify biomarkers underlying risk by characterizing abnormalities in the brain connectome of symptomatic youth at familial risk for BD.

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Individuals at familial risk for mood disorders exhibit deficits in emotional processing and associated brain dysfunction prior to illness onset. However, such brain-behavior abnormalities related to familial predisposition remain poorly understood. To investigate robust abnormal functional activation patterns during emotional processing in unaffected at-risk relatives of patients with major depressive disorder (UAR-MDD) and bipolar disorder (UAR-BD), we performed a meta-analysis of task-based functional magnetic resonance imaging studies using Seed-based d Mapping (SDM) toolbox.

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Objective: Pediatric bipolar disorder (PBD) and attention-deficit/hyperactivity disorder (ADHD) frequently co-occur and share dysfunctions in affective and cognitive domains. As the neural substrates underlying their overlapping and dissociable symptomatology have not been well delineated, a meta-analysis of whole-brain voxel-based morphometry studies in PBD and ADHD was conducted.

Method: A systematic literature search was performed in PubMed, Web of Science, and Embase.

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Age at onset may be an important feature associated with distinct subtypes of amyotrophic lateral sclerosis (ALS). Little is known about the neuropathological mechanism of early-onset ALS (EO-ALS) and late-onset ALS (LO-ALS). Ninety ALS patients were divided into EO-ALS and LO-ALS group, and 128 healthy controls were matched into young controls(YCs) and old controls (OCs).

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  • A study looked at the brains of young people (ages 10-18) with ADHD, some with a family history of bipolar disorder (BD) and some without.
  • The results showed that those at higher risk (with a family history) had more severe symptoms and smaller brain areas compared to those at lower risk and healthy controls.
  • These changes in brain structure may be linked to how serious their ADHD symptoms are, showing that having a family history of BD can affect brain development in kids with ADHD.
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