Quantification of peripapillary nerve fibre elevation and its association with axial length, optic disc tilt, and parapapillary atrophy area in young, healthy eyes.

Background: Eyes with peripapillary nerve fibre elevation (pNFE) may have a gap between the optic nerve papillary margin on colour fundus photography and Bruch's membrane opening on cross-sectional optical coherence tomography (OCT). This study was conducted to evaluate the quantification of the height of pNFE in young healthy eyes and examine the relationship between pNFE height and axial length.

Methods: A prospective, observational, cross-sectional study was performed involving 117 right eyes.

Factors in Color Fundus Photographs That Can Be Used by Humans to Determine Sex of Individuals.

Purpose: Artificial intelligence (AI) can identify the sex of an individual from color fundus photographs (CFPs). However, the mechanism(s) involved in this identification has not been determined. This study was conducted to determine the information in CFPs that can be used to determine the sex of an individual.

Relationship between peripapillary choroidal thickness and degree of tessellation in young healthy eyes.

Purpose: To determine the relationship between the peripapillary choroidal thickness (ppCT) and the degree and distribution of the tessellation in the fundus of normal eyes.

Methods: This was a prospective, observational cross-sectional study of 118 right eyes of young healthy volunteers. The ppCT was measured from the optical coherence tomography (OCT) circle scans manually at eight sectors: the nasal, supranasal superior, supratemporal, temporal, infratemporal, inferior, and infranasal sectors.

Relationship Between Funduscopic Conus and Optic Disc Factors Associated with Myopia in Young Healthy Eyes.

Purpose: To determine the relationship between funduscopic findings in myopic eyes and the prevalence and structure of the conus in the optical coherence tomographic (OCT) images.

Methods: A prospective observational cross-sectional study of 121 right eyes of 121 young healthy volunteers. All participants underwent color fundus photography (CFP), scanning laser ophthalmoscopy, and OCT.

Association Study of Gene Variants with Vogt-Koyanagi-Harada Disease in Japanese Patients.

: To investigate whether variants in the gene encoding KU-MEL-1 are associated with Vogt-Koyanagi-Harada (VKH) disease in a Japanese population. : We recruited 380 Japanese patients with VKH disease and 744 Japanese healthy controls to genotype seven single-nucleotide polymorphisms (SNPs) in . We also performed imputation analysis of the region and 195 imputed SNPs were included in the statistical analysis.

Correlations between local peripapillary choroidal thickness and axial length, optic disc tilt, and papillo-macular position in young healthy eyes.

Optical coherence tomography (OCT) has made it possible for clinicians to measure the peripapillary choroidal thickness (ppCT) noninvasively in various ocular diseases. However, the ocular factors associated with the ppCT have not been conclusively determined. The purpose of this study was to determine the relationship between the local ppCT and the axial length, optic disc tilt, and the angle of the papillo-macular position (PMP) in healthy eyes.

Systemic diseases in patients with HTLV-1-associated uveitis.

Background: Human T-lymphotropic virus type 1 (HTLV-1) carriers may develop severe systemic diseases, such as adult T cell leukaemia (ATL) or HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). This study aims to investigate systemic diseases of HTLV-1 carriers who had developed HTLV-1-associated uveitis (HAU).

Methods: We investigated the occurrence of systemic diseases in 200 patients with HAU by performing a retrospective investigation of their medical records and examining the results of a postal survey.

Correlations Between Retinal Nerve Fiber Layer Thickness and Axial Length, Peripapillary Retinal Tilt, Optic Disc Size, and Retinal Artery Position in Healthy Eyes.

Purpose: To determine the correlations between the retinal nerve fiber layer thickness (RNFLT) and the axial length, peripapillary retinal tilt (PRT), and optic disc size, and retinal artery position.

Methods: A prospective, observational cross-sectional study of 119 healthy right eyes of 119 volunteers. All participants underwent comprehensive ophthalmologic examinations including peripapillary RNFLT imaging and measurements of the axial length.

Peripapillary Nerve Fiber Elevation in Young Healthy Eyes.

Purpose: Eyes with a peripapillary nerve fiber elevation (pNFE) are those with a discrepancy between the optic disc margin in a color fundus photograph and the Bruch's membrane opening in an optical coherent tomographic (OCT) cross-sectional image. The purpose of this study was to determine the prevalence of pNFE in young healthy eyes, and to compare the axial length and optic disc tilt between pNFE and non-pNFE groups.

Methods: This was a prospective, observational, cross-sectional study of 117 right eyes.

Location of Tessellations in Ocular Fundus and Their Associations with Optic Disc Tilt, Optic Disc Area, and Axial Length in Young Healthy Eyes.

Tessellated fundus is found as common and early-phase characteristic of myopic eyes and their locations are varied among patients. However, the relationship between their locations and morphological parameters of the eyes is still unknown. The purpose is this study is to determine the locations of the tessellations in the ocular fundus of young healthy eyes, and to determine relationships between their locations and morphological parameters of the eyes.

Association of retinal thickness and optic disc-to-fovea angle to axial length of young healthy eyes.

Aim: To determine the relationship between the axial length (AL) and the retinal thickness in the posterior pole and to the optic disc-to-fovea (ODF) angle of healthy eyes.

Procedures: A prospective, observational cross-sectional study (registration number, UMIN000006040) of 64 healthy right eyes (mean age 26.0±4.

Bilateral diffuse uveal melanocytic proliferation with mucocutaneous pigmentation.

Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a rare paraneoplastic syndrome associated with extraocular malignancies. Extraocular pigmented lesions have been reported. We report that two patients with BDUMP presented with non-ocular pigmented lesions.

Circumpapillary course of retinal pigment epithelium can be fit to sine wave and amplitude of sine wave is significantly correlated with ovality ratio of optic disc.

The purpose of this study was to develop a method of quantifying the degree of optic disc tilt in normal eyes. This was a prospective, observational cross sectional study of 126 right eyes of 126 healthy volunteers. The optic disc tilt was determined from the circular peripapillary optical coherence tomographic (OCT) scan images.

Posterior pole asymmetry analyses of retinal thickness of upper and lower sectors and their association with peak retinal nerve fiber layer thickness in healthy young eyes.

Purpose: To determine the symmetry of the retinal thicknesses (RT) between the 32 pairs of superior and inferior sectors by posterior pole asymmetrical analysis (PPAA) of the spectral-domain optical coherence tomographic (SD-OCT) images in healthy eyes. In addition, to determine their association with the position of the peak retinal nerve fiber layer (RNFL) thickness.

Methods: A prospective, observational, cross-sectional study of 64 right eyes.

Quantification of retinal nerve fiber and retinal artery trajectories using second-order polynomial equation and its association with axial length.

Purpose: To determine whether a second-degree polynomial equation can fit the retinal nerve fiber (RNF) and retinal artery (RA) trajectories in the posterior pole of eyes and whether the RNF and RA trajectories are correlated with the axial length of the eye.

Methods: This was a prospective observational cross-sectional study of 109 right eyes of 109 healthy participants. All participants underwent axial length measurements, optical coherence tomography (OCT) to determine the peripapillary retinal nerve fiber layer (RNFL) thickness, and red-free fundus photography.

Relationship between supernormal sectors of retinal nerve fibre layer and axial length in normal eyes.

Purpose: To determine the effect of the axial length on the supernormal and false-positive sectors of the peripapillary retinal nerve fibre layer (RNFL) in healthy eyes using the normative database embedded in a spectral domain optical coherence tomographic (SD-OCT) instrument.

Methods: This was a prospective, observational cross -sectional study. The right eyes of 126 healthy young volunteers were studied.

Association between retinal thickness of 64 sectors in posterior pole determined by optical coherence tomography and axial length and body height.

Purpose: We determined a significant correlation between the retinal thickness (RT) in 64 cells or sectors of the posterior pole, and the axial length (AL) and the body height (BH).

Methods: A prospective, observational cross-sectional study of 64 right eyes of 64 healthy volunteers (mean age, 26.0 ± 4.

Relationship between position of peak retinal nerve fiber layer thickness and retinal arteries on sectoral retinal nerve fiber layer thickness.

Purpose: We determined the relationship between the position of the peak of the retinal nerve fiber layer (RNFL) thickness, and the retinal arteries, axial length (AL), and sectoral RNFL thickness in healthy eyes.

Methods: A prospective, observational cross-sectional study (registration number, UMIN000006040) of 50 healthy right eyes (mean age 25.8 ± 3.

Optic disc swelling in Vogt-Koyanagi-Harada disease.

Purpose: This retrospective observational study was designed to evaluate the frequency of, and the factors associated with, optic disc swelling in Vogt-Koyanagi-Harada disease (VKH).

Methods: A retrospective observational study was conducted. We analyzed 116 eyes of 58 patients with VKH.

[A case of cancer-associated retinopathy rapidly leading to blindness with a unique pupillary light reflex].

Background: We herein report a case of cancer-associated retinopathy (CAR) associated with malignant lymphoma, beginning with uveitis and rapidly leading to blindness.

Case: A 54-year-old woman presented with a seven-day history of bilateral progressive vision loss. She had no light perception OU.

[A case of intraocular lymphoma having retinal adverse events associated with intravitreal methotrexate].

Background: We report a case of intraocular lymphoma that developed macular edema and cotton wool spots after treatment with intravitreal methotrexate.

Case: A 56-year-old woman presented with blurred vision OU. Twelve months prior, she had been diagnosed with primary central nervous system lymphoma.

The 101 most frequently cited articles in ophthalmology journals from 1850 to 1949.

We screened 32 ophthalmology journals that had published articles during the period from 1850 through 1949 to identify top-cited articles in the field of ophthalmology (hereafter referred to as citation classics) using the online database Science Citation Index Expanded (Thompson Reuters, Chicago, Illinois). The 101 most frequently cited articles were published in 16 journals. Archives of Ophthalmology had the most top-cited articles (n = 31), followed by American Journal of Ophthalmology (n = 24) and Albrecht von Graefe's Archiv für Ophthalmologie (n = 9).