Publications by authors named "Kumiko Maeda-Nakamura"
Article Synopsis
- Rubratoxin B significantly increases secretion of insulin-like growth factor binding protein-1 (IGFBP-1) in HepG2 cells, peaking at 40 microg/ml, while IGFBP-1 mRNA levels rise and stabilize after 6 hours.
- The study found that although stress-activated MAP kinases (JNKs) do not influence IGFBP-1 secretion, p38 MAP kinases do promote this secretion, with effects seen in both transcriptional and post-transcriptional regulation.
- Concurrently using a p38 inhibitor showed a slight rise in IGFBP-1 mRNA but less than the increase in protein secretion, highlighting the dominant role of p38
