Publications by authors named "Kumiko Ishibashi"
Background: Little is known about the survival impacts of mitochondrial status in esophageal squamous cell carcinoma (ESCC) patients who undergo neoadjuvant chemotherapy (NAC) followed by surgery.
Methods: In total, 260 pre-NAC samples from ESCC patients were analyzed. Mitochondrial status was estimated employing an objective, immunohistochemistry-based system (Mito-score).
Article Synopsis
- - The study highlights the importance of the tumor microenvironment (TME) in managing esophageal squamous cell carcinoma (ESCC) patients, focusing on the impact of immune cell status before and after neoadjuvant chemotherapy (NAC) in 264 patients.
- - While pre-NAC TME status did not significantly affect survival, post-NAC factors like low T cell counts and high PD-L1 levels were linked to significantly poorer overall survival rates, indicating critical changes in immune response after treatment.
- - The research suggests that patients with consistently low levels of T cells and high PD-L1 may benefit from additional treatments, such as immune checkpoint inhibitors (ICIs), emphasizing the need for better stratification based on T
Article Synopsis
- The Rho/Rho-kinase signaling pathway is linked to complications in diabetes, impacting motor nerve conduction velocity (MNCV) in rats.
- Fasudil, a Rho-kinase inhibitor, improved MNCV by suppressing increased Rho-kinase activity and restoring normal levels and distribution of adhesion molecules like p120 catenin and E-cadherin in myelinating Schwann cells.
- The findings suggest that alterations in adhesion molecule expression and localization in the myelin sheath contribute to delayed MNCV in diabetic rats, which fasudil can help mitigate.