Publications by authors named "Kumiko Dokuni"

Article Synopsis
  • * After a median follow-up of 14.2 months, the study found that 20.7% of patients experienced AF recurrence, and only those in the successful group had significant improvements in left atrial (LA) distensibility and stroke volume index post-procedure.
  • * Key independent predictors of AF recurrence included the left ventricular ejection fraction and the baseline Δ LA expansion index, making the latter a reliable marker for assessing RFCA success and indicating improved cardiac
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  • - The study examines the effects of closing atrial septal defects (ASD) on right ventricular overload and functional capacity in adults, finding that some patients remain symptomatic despite closure due to delays in treatment.
  • - Researchers analyzed data from 120 ASD patients and 39 controls, focusing on right ventricular global longitudinal strain (RV-GLS) and the TAPSE/PASP ratio to assess heart function before and after closure.
  • - Findings indicate that preoperative TAPSE/PASP ratio and pulmonary vascular resistance index were significant predictors of postoperative symptoms, highlighting their importance in evaluating treatment outcomes for ASD patients.
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  • The aging process significantly increases the risk of heart failure, especially heart failure with preserved ejection fraction (HFpEF), which affects older individuals more than younger ones.
  • A study involved 102 participants, including 25 with HFpEF and 77 healthy controls, divided into three age groups to assess cardiovascular response to stress through echocardiography.
  • Findings showed that while healthy individuals experienced improved heart function with age-related stress, those with HFpEF did not, indicating that left ventricular remodeling and reduced preload reserve play crucial roles in distinguishing HFpEF from normal aging.
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  • This study investigates the haemodynamic response of patients with heart failure with reduced ejection fraction (HFrEF) to non-invasive preload stress through a combination of semi-sitting and passive leg-lifting positions.
  • 101 HFrEF patients and 35 healthy controls were tested, revealing that changes in stroke volume index (SVi) during postural stress could help identify patients at higher risk for future cardiovascular events.
  • The results suggest this method is an effective and safe way to assess heart function and predict potential risks in HFrEF patients, making it a valuable clinical tool.
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  • The study investigates the cardiovascular outcomes in patients who have undergone repair for tetralogy of Fallot (TOF), focusing on their preload reserve and ventricular interaction during stress testing.
  • It involved 44 TOF patients and 30 control subjects, using echocardiography at rest and during a leg-positive pressure (LPP) maneuver to assess changes in stroke volume and ventricular dimensions.
  • Results showed that while control subjects had a significant increase in stroke volume under stress, TOF patients experienced a much smaller increase, and those with significant pulmonary regurgitation were more likely to have impaired preload reserve.
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This study aimed to test the hypothesis that left ventricular dyssynchrony may negatively affect left atrial (LA) dyssynchrony and reservoir function, and cardiac resynchronization therapy (CRT) may improve LA function. It also assessed, whether residual LA dyssynchrony affects the prognosis in patients with heart failure with reduced ejection fraction (HFrEF). Ninety subjects were included: 40 HFrEF patients with a wide-QRS complex (≧130 ms), 28 HFrEF patients with a narrow-QRS, and 22 normal controls.

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Background: Coexistence of left ventricular (LV) longitudinal myocardial systolic dysfunction with LV diastolic dysfunction could lead to heart failure with preserved ejection fraction (HFpEF). Diabetes mellitus (DM) is known as a significant factor associated with HFpEF. Although the mechanisms of DM-related LV myocardial injury are complex, it has been postulated that overweight contributes to the development of LV myocardial injury in type 2 diabetes mellitus (T2DM) patients.

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