Publications by authors named "Kumi Fukushima"
Earth is the only terrestrial planet in our solar system where an oceanic plate subducts beneath an overriding plate. Although the initiation of plate subduction requires extremely weak boundaries between strong plates, the way in which oceanic mantle rheologically weakens remains unknown. Here we show that shear-enhanced hydration reactions contribute to the generation and maintenance of weak mantle shear zones at mid-lithospheric depths.
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- The study highlights the importance of BMP signaling in organ development, particularly in the formation of mammalian nephrons.
- The secreted factor Cv2 enhances BMP signaling, as shown by reduced nephron progenitor clusters and diminished phosphorylated Smad1 levels in Cv2-null mice.
- Additionally, the defects observed in Cv2-null mice could be countered by mutations that eliminate Twisted gastrulation (Tsg), suggesting a cooperative interaction between these BMP-binding factors during early nephrogenesis.
Bone morphogenetic protein (BMP) signaling controls various aspects of organogenesis, including skeletal development. We previously demonstrated that the pro-BMP function of Crossveinless 2 (Cv2) is required for axial and non-axial skeletal development in mice. Here, we showed that skeletal defects in the Cv2-null mutant were reversed by the additional deletion of Twisted gastrulation (Tsg).
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