Healing Trauma While Staying at Home: Using Telehealth to Conduct a Brief Treatment Program for Posttraumatic Stress Disorder.

Studies suggest that a three-session brief treatment program (Brief Relaxation, Education, and Trauma Healing [BREATHE]) can help treat posttraumatic stress disorder (PTSD) and symptoms of trauma; however, the program has not been examined via telehealth. Thus, the current study evaluated the feasibility of BREATHE delivered via telehealth. The intervention included breathing retraining and psychoeducation about PTSD and trauma.

Absorption, degradation and excretion of benzo(a)pyrene in the cricket (Acheta domesticus).

1. The absorption, degradation and excretion of 3H-benzo(a)pyrene (3H-BP) was examined in the cricket (Acheta domesticus). 2.

Effect of subconjunctivally administered antineoplastics on experimentally induced intraocular malignant tumour.

Twice-weekly subconjunctival injections of 5-fluorouracil (5-FU), 6-mercaptopurine (6-MP), cytarabine (ARA-C) and methotrexate (12.5 mg, 20 mg, 75 mg and 12.5 mg per dose respectively) were used to treat Greene melanoma implanted in the anterior chamber of the eyes of three groups of New Zealand rabbits: group 1 (14 animals), the control group, received saline, group 2 (16 animals) received treatment beginning immediately after tumour implantation and group 3 (15 animals) received treatment starting 1 week after implantation.

Response of an ocular melanoma to subconjunctival injection of 5-thio-D-glucose or cis-platin.

Successful treatment of ocular tumours by chemotherapy and radiotherapy is sometimes limited by the special nature of the eye. Improvement is needed to avoid enucleation. Previous studies using locally administered antineoplastic agents have given promising results in the treatment of experimental ocular melanoma and spontaneous lymphoma.

Ocular penetration, toxicity, and radiosensitization effects of two hypoxic cell radiosensitizers on retinoblastoma.

Two new radiosensitizing drugs, SR-2508 and SR-2555, were studied for their in vivo toxicity and absorption properties. For both drugs, 100 mg dissolved in 0.5 mL of normal saline resulted in the maximum acceptable level of toxicity when injected subconjunctivally in rabbit eyes as determined by ocular and histopathologic changes.

Ocular absorption and toxicity of methotrexate in the dog.

The ocular absorption, elimination and toxicity of 12.5 mg of methotrexate in 0.5 cc administered subconjunctivally was studied in the dog.

Effects of subconjunctivally injected antineoplastic agents on three models of corneal inflammation.

Three models of corneal inflammation--acute toxic keratitis, phlyctenular keratitis and corneal graft rejection--were induced in rabbits and treated with subconjunctival injections of antineoplastic agents (methotrexate, cytosine arabinoside, 5-fluorouracil and 6-mercaptopurine) and Solu-Medrol (methylprednisolone sodium succinate). The inflammations responded to the drugs to various degrees when compared with the response in control animals treated with saline. Cytosine arabinoside effected a slight decrease in the clinical features of acute toxic keratitis, methotrexate was superior in decreasing inflammation and neovascularization in phlyctenular keratitis, and Solu-Medrol appeared to be the most useful in the treatment of graft rejection.

Ocular pharmacokinetics of subconjunctivally versus intravenously administered 6-mercaptopurine.

The levels of 6-mercaptopurine (6-MP) were measured in the anterior chamber aqueous, the vitreous and the serum of rabbits 0.5, 1, 2, 4, 8 and 12 hours following subconjunctival or intravenous injection of 10 mg/kg in 0.5 mL of saline, the maximum tolerated dose as determined experimentally.

Subconjunctival versus intravenous cytosine arabinoside: effect of route of administration and ocular toxicity.

The ocular penetration, elimination, and toxicity of equidose cytosine arabinoside (Ara-C) (37.5 mg/kg) following subconjunctival versus intravenous injection were compared in rabbits. Drug levels were measured at 0.