Effect of epoetin zeta for correction of renal anemia in hemodialysis patients with thalassemia minor.

Two patients with thalassemia minor and end-stage renal failure on hemodialysis were treated with epoetin zeta (Silapo, Retacrit; STADA, Germany), a medicinal product that was developed and registered as biosimilar to epoetin alfa. Dosing was titrated individually for two patients to achieve a stable hemoglobin (Hb) concentration of 10.5-12.

Effect of mycophenolate mofetil (Cell Cept) in the treatment of immune glomerulopathies.

Aim: To study the effect of mycophenolate mofetil (Cell Cept) in treating patients with various types of chronic glomerulonephritis and other immune nephropathies.

Material And Methods: Between 2000 and 2003 we treated 35 patients (18 women, 17 men) with Cell Cept (La Roche). In 32 patients the diagnosis was confirmed by kidney biopsy (immunofluorescence, light and electron microscopy).

Epoetin-beta (Recormon-Roche) in the treatment of renal anemia in patients with chronic renal failure.

Unlabelled: In the study a clinical assessment is made of the results of treatment of patients with renal anemia by epoetin-beta.

Material And Methods: Thirty two patients (22 women, 10 men) with chronic renal failure and anemia, ranging from 18 to 77 years of age (mean age 46.29 +/- 5.

Cyclosporin A in the treatment of patients with nephrotic syndrome.

Objective: To present our experience in the treatment of conventional therapy refractory nephrotic syndrome with cyclosporin A.

Material And Methods: The study sample included 22 patients (12 men, 10 women, aged 40.43 +/- 5.

Low protein diet and ketosteril in predialysis patients with renal failure.

Unlabelled: After a short review of the contemporary understanding of amino acid supplementation to low protein diets in patients with uremia we present the results of administration of ketosteril in 20 low-protein-diet patients on such a diet.

Material And Methods: Twenty patients (10 men and 10 women) with stable II and III stage chronic renal failure were assigned to a low protein diet (protein up to 40 g/day). Ketosteril (6 tablets a day) were added to the diet.

Influence of age, sex and body weight on renal osteodystrophy in predialysis patients with chronic renal failure.

Unlabelled: The aim of the present investigation was to examine the influence of age, sex and body weight on osseous changes in pre-dialysis patients with chronic renal failure (CRF). 87 patients (44 males and 43 females) aged 18-60 years with CRF were studied. The levels of serum creatinine, total and ionized calcium, phosphorus, alkaline phosphatase, intact parathormone and serum osteocalcine were followed up.

Assessment of serum osteocalcine level in pre-dialysis patients with chronic renal failure.

Unlabelled: The application of serum osteocalcine as a marker of osseous synthesis in patients with renal osteodystrophy is still disputable because of its predominantly renal excretion. The aim of the present study was to investigate the level of serum osteocalcine in pre-dialysis patients with chronic renal failure (CRF).

Material And Methods: 47 patients aged 22-60 years (26 males and 22 females) with chronic renal failure were studied.

Treatment of immune nephropathies with high doses of immunoglobulins.

Unlabelled: The present study presents the results from the application of high doses of gamma-globulin in the treatment of immune (idiopathic and satellite) glomerulopathies.

Materials And Methods: Twenty patients were treated. Of these 12 were with primary chronic glomerulonephritis, 7--with lupus nephritis and 1--with renal amyloidosis.

On the disturbances in carbohydrate metabolism in pre-dialysis patients with chronic renal failure.

Unlabelled: We describe some of the aspects of impaired carbohydrate metabolism in predialysis uremic patients.

Methods: A total of seventy-five nondiabetic patients with chronic renal failure (CRF) were enrolled in the present study. The level of glycosylated hemoglobin was measured in 51 patients using kits from Merck and an oral glucose challenge test was performed in 20 according to a standard protocol.

Our experience in the combined pathogenetic treatment of chronic glomerulonephritis.

Unlabelled: The most common combined pathogenetic treatment regimens for the treatment of chronic glomerulonephritis are the object of the present study. It is not quite uncommon in everyday clinical practice for the physician to encounter patients with similar pathohistologic patterns who respond differently to a standard therapeutic schedule.

Methods: Having in mind the complexity of the problem we analyzed our ten-year experience with the combined pathogenetic treatment of 150 patients, aged 17 to 52, with histologically proven chronic glomerulonephritis.

Cyclic adenosine monophosphate (cAMP) levels in predialysis patients with chronic renal failure.

We studied the changes in the urinary cAMP level in fifty-five predialysis patients (30 men and 25 women) with chronic renal failure (CRF). The excretion of cAMP in 20 patients with first-degree CRF (serum creatinine levels below 356.6 mmol/I) and 15 patients with second or third degree CRF (serum creatinine below 800 mmol/I) was compared with that of 20 age-matched controls using the original I-125 RIA (radioimmunoassay) kit of Incstar Corporation, USA.

Clinical electron microscopic correlations in patients with glomerulonephritis.

The purpose of the present study was to perform an electron microscopic investigation of patients with chronic glomerulonephritis and to find correlations between the type of glomerular disorder and the features of the clinical course of the disease. 26 patients--16 female and 10 male aged 17-62 years (mean age, 34.5 years) were investigated.

External respiration in patients with chronic renal failure in a predialysis state.

The purpose of this study was to make functional assessment of the external respiration in patients with chronic renal failure (CRF) in a predialysis state and to find some early indicators for uremic lung impairment. Twenty two patients (13 men, 9 women, aged 30 to 65) with different renal diseases were investigated. According to the stage of progression of CRF we allocated the patients to two groups-14 patients with stage I CRF (serum creatinine up to 353.

Study of the effect of recombinant erythropoietin on renal anaemia in predialysis patients with chronic renal failure.

Recombinant erythropoietin was given to six renal anaemia patients (2 male and 4 female, aged 38-66 years) with chronic renal failure in the predialysis state. Eprex (Cilag, Switzerland) was used in the treatment. The preparation was administered subcutaneously, thrice weekly for 6 months, at a mean dose of 50 U/kg.

Glomerular hyperfiltration and serum beta 2-microglobulin used as early markers in diagnosis of autosomal dominant polycystic kidney disease.

This study was undertaken to investigate the dynamics of glomerular filtration and serum beta 2-microglobulin in patients with confirmed autosomal dominant polycystic kidney disease (ADPKD) without chronic renal failure (CRF). Twenty five patients (11 women and 14 men, age range 15 to 56 years) with echographically and computer-tomographically proven ADPKD were entered into the study. Glomerular filtration was followed using the 24 hour creatinine clearance and beta 2-microglobulin serum level was measured radioimmunologically using an ABBOTT laboratories kit.

Ionized calcium in patients with chronic renal failure.

Parameters of various renal disorders were studied in 31 patients (17 men and 14 women) who all were in the stage of chronic renal failure (CRF). These parameters included total serum creatinine, ionized calcium, serum creatinine, creatinine clearance and acid-base balance. The results were compared with a control group of 30 healthy subjects.

[The hemolytic-uremic syndrome during contraceptive prevention with Rigevidon].

A case of a 20-year-old woman who developed a hemolytic-uremic syndrome while using the contraceptive drug Rigevidon is reported. Clinically the disease was manifested by acute renal failure, thrombocytopenic purpura and hemolytic anemia. The treatment with antiaggregants, anticoagulants, hemodialysis and plasmapheresis was without effect.

[Urinary magnesium excretion in nephrolithiasis].

Magnesium urine excretion and its correlation with calcium urine excretion were studied in 152 patients with nephrolithiasis by atomic-absorption spectrophotometry. In 14.5% of the patients with unilateral nephrolithiasis and in the 25.