Mining for antifungal agents to inhibit biofilm formation of Candida albicans: A study on green synthesis, antibiofilm, cytotoxicity, and in silico ADME analysis of 2-amino-4H-pyran-3-carbonitrile derivatives.

Candida albicans (C. albicans) biofilm infections are quite difficult to manage due to their resistance against conventional antifungal drugs. To address this issue, there is a desperate need for new therapeutic drugs.

Intrinsically Conductive and Cu-Functionalized Polymer-Composite Membranes as Gas Diffusion Electrodes for CO Electroreduction.

We introduced a new class of gas diffusion electrodes (GDEs) with adjustable pore morphology. We fabricated intrinsically conductive polymer-composite membranes containing carbon filler, enabling a pore structure variation through film casting cum phase separation protocols. We further selectively functionalized specific pore regions of the membranes with Cu by a NaBH-facilitated coating strategy.

Effect of Progressive Balance Control Strategies on Chronic Ankle Instability in Middle-Aged Obese Women.

Introduction: Chronic ankle instability (CAI) is a disease characterized by persistent feelings of instability in the ankle joint and a propensity for recurrent ankle sprains. It is often caused by ligamentous laxity or neuromuscular deficits. Middle-aged obese females represent a demographic subset at increased risk for CAI due to factors such as reduced proprioception and increased loading on the ankle joint.

Analysis and Validation of Image Search Engines in Histopathology.

Searching for similar images in archives of histology and histopathology images is a crucial task that may aid in patient tissue comparison for various purposes, ranging from triaging and diagnosis to prognosis and prediction. Whole slide images (WSIs) are highly detailed digital representations of tissue specimens mounted on glass slides. Matching WSI to WSI can serve as the critical method for patient tissue comparison.

Tunable Syngas Formation at Industrially Relevant Current Densities via CO Electroreduction and Hydrogen Evolution over Ni and Fe-derived Catalysts obtained via One-Step Pyrolysis of Polybenzoxazine Based Composites.

Simultaneous electroreduction of CO and HO to syngas can provide a sustainable feed for established processes used to synthesize carbon-based chemicals. The synthesis of MO/M-N-Cs (M = Ni, Fe) electrocatalysts reported via one-step pyrolysis that shows increased performance during syngas electrosynthesis at high current densities with adaptable H/CO ratios, e.g.

The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial.

In animal studies, β-nicotinamide mononucleotide (NMN) supplementation increases nicotinamide adenine dinucleotide (NAD) concentrations and improves healthspan and lifespan with great safety. However, it is unclear if these effects can be transferred to humans. This randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial included 80 middle-aged healthy adults being randomized for a 60-day clinical trial with once daily oral dosing of placebo, 300 mg, 600 mg, or 900 mg NMN.

Peritoneal lavage during laparoscopic appendectomy for complex appendicitis is associated with increased post-operative morbidity.

Aim: Appendicitis is one of the most common paediatric surgical pathologies seen by paediatric surgeons worldwide. Laparoscopic appendectomy is undertaken for all cases of appendicitis in our institute. Intraperitoneal lavage following appendectomy is the conventional way of managing complicated appendicitis; however, some surgeons debate the efficacy of this practice.

GLUT-2 mediated glucose uptake analysis of : and approach.

Background: Type-2 diabetes mellitus is a common metabolic disorder characterized by insulin resistance, a relative impairment in insulin secretion, and a certain degree of genetic predisposition. The rapid rise in the prevalence of diabetes mellitus around the world has assisted in the development of new pharmacologically active compounds. The current study was aimed to investigate and validate the anti-diabetic activity of wild-grown plant L.

promotes the glucose uptake- Evidence with and .

Background: L. is traditionally used to manage diabetes; also used in various herbal formulations, and is indicated as an insulin sensitizer. Hence, present work attempted in identifying the probable lead hits to promote glucose uptake computational approach followed by experimental evaluation of hydroalcoholic extract of L.

Photoelectrochemical H evolution on WO/BiVO enabled by single-crystalline TiO overlayer modulations.

Tungsten oxide/bismuth vanadate (WO/BiVO) has emerged as a promising photoanode material for photoelectrochemical (PEC) water splitting owing to its facilitated charge separation state differing significantly from single phase materials. Practical implementation of WO/BiVO is often limited by poor stability arising from the leaching of V from BiVO during PEC operations. Herein, we demonstrate that the synthesis of a tungsten oxide/bismuth vanadate/titanium oxide (WO/BiVO/TiO) heterostructure onto a fluorine-doped tin oxide-coated glass substrate through a combined simple hydrothermal-spin coating strategy will advance PEC performance while slowing water oxidation kinetics and improving photostability.

Efficacy of fibrin sealant as waterproof cover in improving outcome in hypospadias surgery.

Background: This prospective comparative study aims to assess the efficacy of fibrin sealant to improve outcomes in paediatric patients operated for hypospadias.

Materials And Methods: Forty consecutive patients with hypospadias were randomised into two groups of twenty patients each. The first group underwent hypospadias repair, technique depending on the type of hypospadias, whereas in the second group, fibrin sealant was used to reinforce the urethroplasty.

Emergency scrotal exploration in children: Is it time for a change in mindset in the UK?

Introduction: Acute scrotal pain is a common problem in children. Amongst the various causes, only testicular torsion (TT) needs urgent, and arguably any, surgical intervention. However TT accounts for only approximately 25% of cases.

Interfacial growth of the optimal BiVO nanoparticles onto self-assembled WO nanoplates for efficient photoelectrochemical water splitting.

Photoelectrochemical water splitting is the most efficient green engineering approach to convert the sun light into hydrogen energy. The formation of high surface area core-shell heterojunction with enhanced light-harvesting efficiency, elevated charge separation, and transport are key parameters in achieving the ideal water splitting performance of the photoanode. Herein, we demonstrate a first green engineering interfacial growth of the BiVO nanoparticles onto self-assembled WO nanoplates forming WO/BiVO core-shell heterojunction for efficient PEC water splitting performance.

Insights into the interfacial nanostructuring of NiCoS and their electrochemical activity for ultra-high capacity all-solid-state flexible asymmetric supercapacitors.

Ternary metal sulfide based nanostructured materials are promising for commercialization of the electrochemical energy storage devices. Herein, three different NiCoS nanostructures (nanoflakes, nanosheets, and nanoparticles) were fabricated by electrodeposition. Of these, nanosheets consisting of interconnected nanoparticles formed a highly porous network for supercapacitive energy storage.

Using chemical bath deposition to create nanosheet-like CuO electrodes for supercapacitor applications.

We report the effect of ionic liquids on chemically synthesized hierarchical-like copper oxide (CuO) thin films for supercapacitor applications. Concisely, the CuO thin films were deposited via chemical bath deposition (CBD) using 2-dimethylimidazolium chloride [HPDMIM(C1)], 1-(2',3'-dihydroxypropyl)-3-methylimidazolium chloride [DHPMIM(C1)], and N-(3-methyl-2-oxopropyl)pyridine chloride [MOCPP(C1)] ionic liquid solvents. The effects of the ionic liquid solvents on the morphological evolution of the as-prepared films were analyzed, and electrochemical properties were investigated.

An open-label, interventional, single-center, prospective clinical study to evaluate the efficacy and safety of "AHPL/AYTAB/1514" in patients suffering from halitosis.

Objectives: The main objective of the study was to assess the efficacy and safety of AHPL/AYTAB/1514 tablet in patients suffering from halitosis.

Methodology: Fifty four patients were recruited in the study. Patients were advised to take maximum two tablets or at least one tablet four times a day (depending on tolerability of the drug) orally for 60 days.

Mimicking the Synaptic Weights and Human Forgetting Curve Using Hydrothermally Grown Nanostructured CuO Memristor Device.

In the present investigation, we have fabricated copper oxide (CuO) thin film memristor by employing a hydrothermal method for neuromorphic application. The X-ray diffraction pattern confirms the films are polycrystalline in nature with the monoclinic crystal structure. The developed devices show analog memory and synaptic property similar to biological neuron.

Desmosis coli - a case report and review of the literature.

Desmosis coli is a rare pathology presenting as slow transit constipation. In this case we would like to discuss the presentation and management of desmosis coli. A 14-month-old female hailing from western India with a history of chronic constipation presented with acute massive abdominal distension and vomiting.

Traumatic duodenal injury in children: A report of two cases.

Duodenal injury following blunt abdominal trauma in children is extremely rare. It commonly has a delayed presentation, thus leading to increased mortality and morbidity. We report two cases of isolated duodenal injury following blunt abdominal trauma in children.

An Open Label, Randomized, Comparative, Parallel Group, Multicenter, Prospective, Interventional, Clinical Study to Evaluate Efficacy and Safety of "AHPL/AYTOP/0113" in Comparison with "Framycetin Sulphate Cream" in Acute Wounds.

Objectives: The main objective of the present study was to assess efficacy and safety of AHPL/AYTOP/0113 cream, a polyherbal formulation in comparison with Framycetin sulphate cream in acute wounds.

Methodology: It was an open label, randomized, comparative, parallel group and multi-center clinical study. Total 47 subjects were randomly assigned to Group-A (AHPL/AYTOP/0113 cream) and 42 subjects were randomly assigned to Group-B (Framycetin sulphate cream).

Anaesthesia for foetoscopic Laser ablation- a retrospective study.

Background And Aims: Twin pregnancy with monochorionic placenta may be associated with arteriovenous vascular anastomosis of the placental vessels resulting in twin-to-twin transfusion syndrome (TTTS) and twin reversed arterial perfusion syndrome (TRAP). Foetoscopic LASER ablation (FLA) is the treatment of choice in reducing foetal mortality related to this.

Methods: A retrospective review of medical records of 41 FLA procedures for TTTS and TRAP were analysed for anaesthetic management.

Fetus in Fetu: Two Cases and Literature Review.

Fetus in fetu is a rare cause of abdominal mass in infants wherein a parasitic twin grows inside a host. The true etiology is unclear. Various theories have been postulated.

Electrochemical behavior of chemically synthesized selenium thin film.

The facile and low cost simple chemical bath deposition (CBD) method is employed to synthesize red colored selenium thin films. These selenium films are characterized for structural, morphological, topographical and wettability studies. The X-ray diffraction (XRD) pattern showed the crystalline nature of selenium thin film with hexagonal crystal structure.