Publications by authors named "Kumaraswamy Honnenahally Malleshappa"
Article Synopsis
- - Pancreatic cancer is challenging to treat due to late detection and low survival rates; researchers are exploring the use of heterocycles, specifically quinoline and pyridine ring systems, to enhance cancer drug efficacy through the Suzuki-Miyaura coupling method.
- - The study focuses on targeting the VEGFR2 protein, which is overexpressed in pancreatic cancer, by designing quinoline-coupled pyridine compounds that can inhibit this pathway.
- - Testing revealed that compounds 5d, 5e, and 5h showed significant inhibitory effects on pancreatic cancer cell lines, with 5e emerging as a potential lead for developing new treatments.
Antiproliferative Effects of Fruit Extract and its Bioactive Fraction through Upregulation of p53/γH2AX Signals and G2/M Phase Arrest in MIA PaCa-2 Cells.
Meghana Pargi Sandeep Kumar Jain Raviraj Prashanth Narayanappa Santhosh Kumar J Urumarudappa Pallavi Malleshappa Kumaraswamy Honnenahally Malleshappa
Anticancer Agents Med Chem
August 2022
Background: Artabotrys odoratissimus (Annonaceae) is a medicinal and ornamental plant widely cultivated in Southeast Asia for its famous ylang ylang essential oil. The fruits of this plant are used for health benefits, but very little is studied about the bioactive principles, their role in regulating oxidative stress and tumour progression.
Objective: The study aimed to evaluate the antiproliferative effects of fruit extract of Artabotrys odoratissimus and its bioactive fraction using cell-based assays.