Publications by authors named "Kumarasinghe P"

Article Synopsis
  • Lymphocyte-rich inflammation of the esophagus is an emerging condition characterized by symptoms like difficulty swallowing and food blockages, often appearing similar to eosinophilic esophagitis during endoscopy.
  • Three main subtypes of this inflammation have been identified: lymphocytic, lichenoid, and lymphocyte-predominant esophagitis, which must be differentiated from other causes such as gastro-esophageal reflux and Candida infections.
  • The review highlights the need for systematic diagnostic criteria and recommends more research to understand the disease's progression and improve treatment strategies for affected patients.
View Article and Find Full Text PDF

This study compares hindering and fostering factors for SMEs in China and Sri Lanka in their internationalization efforts through e-commerce. The study uses qualitative research methods to examine how SMEs in both countries utilize e-commerce platforms for global expansion. Narrative and thematic analysis techniques focus on manufacturing sector SMEs actively engaged in global expansion through e-commerce.

View Article and Find Full Text PDF

This research examines the impact of the Regional Comprehensive Economic Partnership (RCEP) on the textile and apparel industry within its member nations. The study seeks to understand the implications of RCEP on trade dynamics, innovation chains, and industrial integration in the textile sector. The study uses both quantitative analysis of trade data and qualitative assessment of policy frameworks to analyze changes in textile trade and patterns among RCEP members through UN Comtrade data.

View Article and Find Full Text PDF
Article Synopsis
  • Scientists studied how tick bites affect skin to understand diseases caused by ticks.
  • They found many genes that behaved differently in skin right after a tick bite compared to skin taken later, showing how the body reacts over time.
  • The research could help identify markers to predict how a person will respond to tick bites and help with treatments in the future.
View Article and Find Full Text PDF
Article Synopsis
  • - NIFTP is a newly classified thyroid neoplasm that has replaced the previous diagnosis of a certain type of thyroid cancer, with varying adoption rates noted across different global regions.
  • - A survey of 48 pathologists showed a 94% adoption rate for diagnosing NIFTP, with North American pathologists diagnosing it more frequently than those in Europe and Asia/Oceania.
  • - Significant differences exist in how pathologists assess nuclear features, especially for moderate changes, leading to regional variations in NIFTP diagnosis, with North American and European pathologists generally using lower thresholds for diagnosis compared to their counterparts in Asia/Oceania.
View Article and Find Full Text PDF

Background: Indigenous children in colonised nations experience high rates of health disparities linked to historical trauma resulting from displacement and dispossession, as well as ongoing systemic racism. Skin infections and their complications are one such health inequity, with the highest global burden described in remote-living Australian Aboriginal and/or Torres Strait Islander (hereafter respectfully referred to as Aboriginal) children. Yet despite increasing urbanisation, little is known about the skin infection burden for urban-living Aboriginal children.

View Article and Find Full Text PDF

In recent years, the business landscape has been reshaped by the fusion of manufacturing and service industries, driven by the "Internet+" initiative and the integration efforts of the Chinese government. This research focuses on the behavior model of service-derived manufacturing within e-commerce enterprises, specifically emphasizing a well-known Chinese enterprise. The study used a case study approach to analyze the manufacturing transformation process.

View Article and Find Full Text PDF

While women pathologists have made up over one-third of pathologists in the Australian workforce for over 15 years and at least 50% since 2019, they are under-represented in senior leadership roles, scientific publications, grant recipients, editorial boards, key presentations, and professional awards. This is not unique to pathology and is seen in the broader medical and academic community. Barriers to gender equity and equality in pathology, medicine and academia include gender stereotypes, gender-based discrimination, structural and organisational barriers as well as broader social and cultural barriers.

View Article and Find Full Text PDF

Ticks are ectoparasites that cause dermatologic reactions directly by their bites and indirectly as vectors of bacterial, protozoal and viral diseases. Consequences vary from minor local reactions to significant systemic sequelae and are therefore of clinical relevance to dermatologists. In this article, Australian ticks of medical importance are reviewed through the lens of dermatology.

View Article and Find Full Text PDF

Aims: To explore clinical characteristics, perioperative management and outcomes of Hip Fracture patients with advanced Chronic Kidney Disease (HF-aCKD) compared to the general Hip Fracture population without aCKD (HF-G) within a large volume tertiary hospital in Western Australia.

Methods: Retrospective chart review of patients admitted with hip fracture (HF) to a single large volume tertiary hospital registered on Australian and New Zealand Hip Fracture Registry (ANZHFR). We compared baseline demographic and clinical frailty scale (CFS) of HF-aCKD (n = 74), defined as eGFR < 30 mls/min/1.

View Article and Find Full Text PDF

In Australia, there is a paucity of data about the extent and impact of zoonotic tick-related illnesses. Even less is understood about a multifaceted illness referred to as Debilitating Symptom Complexes Attributed to Ticks (DSCATT). Here, we describe a research plan for investigating the aetiology, pathophysiology, and clinical outcomes of human tick-associated disease in Australia.

View Article and Find Full Text PDF

Background: A high burden of bacterial skin infections (BSI) is well documented in remote-living Indigenous children and young people (CYP) in high-income countries (HIC). Atopic dermatitis (AD) is the most common chronic inflammatory skin condition seen in CYP and predisposes to BSI. Despite the rate of urbanization for Indigenous people increasing globally, research is lacking on the burden of AD and BSI for urban-living Indigenous CYP in HIC.

View Article and Find Full Text PDF

Aims: Fundic gland polyps (FGPs) comprise 66% of all gastric polyps. Although they are usually non-syndromic, they may be associated with various syndromes, including familial adenomatous polyposis (FAP) or gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS). We aimed to evaluate how histological features relate to distinct FGP subtypes.

View Article and Find Full Text PDF

Context.—: A standardized detailed surgical pathology report is the cornerstone of gastric cancer management.

Objective.

View Article and Find Full Text PDF

(1) Background: Accurate preoperative identification of medullary thyroid carcinoma (MTC) is challenging due to a spectrum of cytomorphologic features. However, there is a scarcity of studies describing the cytomorphologic features as seen on fine-needle aspiration (FNA) smears prepared using different staining methods. (2) Methods: We performed a retrospective study on MTC cases with available FNA slides from 13 hospitals distributed across 8 Asia-Pacific countries.

View Article and Find Full Text PDF

A 56-year-old woman with hypohidrotic ectodermal dysplasia presented with a 10-year history of persisting wart-like skin lesions on her feet. Biopsy revealed changes of eccrine syringofibroadenoma. These lesions are rare, with only nine case reports describing an association with ectodermal dysplasia of hidrotic type (Clouston and Schopf's syndrome).

View Article and Find Full Text PDF

Background And Objectives: A standardized data set for esophageal carcinoma pathology reporting was developed based on the approach of the International Collaboration on Cancer Reporting (ICCR) for the purpose of improving cancer patient outcomes and international benchmarking in cancer management.

Materials And Methods: The ICCR convened a multidisciplinary international expert panel to identify the best evidence-based clinical and pathological parameters for inclusion in the data set for esophageal carcinoma. The data set incorporated the current edition of the World Health Organization Classification of Tumours of the Digestive System, and Tumour-Node-Metastasis staging systems.

View Article and Find Full Text PDF

Background: Barrett oesophagus is a known precursor of oesophageal adenocarcinoma (EAC). Early EAC includes T1a (invasion into mucosa) and T1b (invasion into submucosa but not muscularis propria). Endoscopic mucosal resection (EMR) provides accurate histological staging and definitive treatment for early EAC.

View Article and Find Full Text PDF

Background: The purpose of the current study was to examine the impact of coronavirus disease 2019 (COVID-19) on various aspects of cytology practice in the Asia-Pacific region.

Methods: An online questionnaire was distributed to cytopathology laboratories in 24 Asia-Pacific countries to explore the impact of restrictive measures on access to health care, use of general and personal protective equipment (PPE), and changes in cytology workflow and workload from February to April 2020.

Results: A total of 167 cytopathology laboratories from 24 countries responded to the survey; the majority reported that restrictive measures that limited the accessibility of health care services had been implemented in their cities and/or countries (80.

View Article and Find Full Text PDF

Aim: The optimal management strategy for patients with endoscopically resected malignant colorectal polyps (MCP) has yet to be defined. The aim of this study was to validate a published decision-making tool, termed the Scottish Polyp Cancer Study (SPOCS) algorithm, on a large international population.

Methods: The SPOCS algorithm allocates patients to risk groups based on just two variables: the polyp resection margin and the presence of lymphovascular invasion (LVI).

View Article and Find Full Text PDF

Background: The accurate preoperative identification of medullary thyroid carcinoma (MTC) is challenging due to the rarity of tumor and variable cytologic appearance. The Asian experience with diagnosing MTC by fine-needle aspiration (FNA) was scarcely reported.

Methods: Cases of MTC with available FNA slides were enrolled from 13 hospitals representing 8 Asia-Pacific countries.

View Article and Find Full Text PDF

Background And Study Aims: Endoscopically resected malignant colorectal polyps (MCPs) present a dilemma regarding whether the risk of residual disease justifies a major bowel resection. Overtreatment is common, and the vast majority of patients who undergo resection have no residual tumor. The aim of this study was to investigate whether revising the definition of vertical margin involvement following MCP polypectomy could reduce unnecessary surgery.

View Article and Find Full Text PDF