Experience With Dabigatran on Rate of Portal Vein Thrombosis Recanalization, Disease Progression and Survival.

Background And Aims: We assessed clinical, procoagulant and genetic risk factors and clinical outcomes in dabigatran-treated patients with non-tumoural acute and acute-on-chronic portal vein thrombosis (PVT).

Methods: Patients with a new diagnosis of non-tumoural acute and acute-on-chronic PVT between January 2021 and January 2024 (aged ≥ 18 years) in those without/with cirrhosis (Child-Pugh (CP)-A/B/C ≤ 10) were started on dabigatran and followed and compared with those on vitamin K antagonist (VKA) and untreated individuals.

Results: Dabigatran was prescribed in 119 patients with PVT type 1 (61, 51.

Coagulopathy in acute liver failure.

Acute liver failure (ALF) is a rare but rapidly progressing syndrome, marked by severe liver dysfunction and altered mental status. While definitions of ALF vary across different guidelines, with timelines ranging from 4 to 26 weeks between jaundice onset and encephalopathy, the key defining features remain encephalopathy and coagulopathy. Elevated coagulation markers, particularly prothrombin time and international normalized ratio, have traditionally been associated with bleeding risks.

Magnetic nanoparticle-catalysed synthesis of quinoline derivatives: A green and sustainable method.

Greener and sustainable synthetic strategies have been evolving as the demanding domain of organic synthesis during the last decade. Green synthesis involves the development of method that decrease or eliminate the use of hazardous chemicals, and make use of renewable or recyclable resources. By incorporating the fundamentals and methodologies of green synthesis, organic chemists have the ability to develop valuable organic molecular frameworks which also demonstrate a strong commitment to environmental sustainability.

Monte Carlo-based dosimetry of proposed bi-radionuclide (I and Ru/Rh) eye plaque: A feasibility study.

Background: Combining the sharp dose fall off feature of beta-emitting Ru/Rh radionuclide with larger penetration depth feature of photon-emittingI radionuclide in a bi-radionuclide plaque, prescribed dose to the tumor apex can be delivered while maintaining the tumor dose uniformity and sparing the organs at risk. The potential advantages of bi-radionuclide plaque could be of interest in context of ocular brachytherapy.

Purpose: The aim of the study is to evaluate the dosimetric advantages of a proposed bi-radionuclide plaque for two different designs, consisting of indigenous I seeds and Ru/Rh plaque, using Monte Carlo technique.

Endoscopic Ultrasound Guided Radiofrequency Ablation for Caudate Lobe Hepatocellular Carcinoma: A New Paradigm in Endohepatology.

Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) is a promising technique for treating small left hepatic lesions, particularly where ablation via percutaneous route is deemed to be technically difficult. Herein, we report a case of a 64-year-old cirrhotic patient with caudate lobe hepatocellular carcinoma (HCC) who underwent EUS-RFA, resulting in complete ablation of the tumor and also review the related literature.

Regioselective synthesis of 4-arylamino-1,2-naphthoquinones in eutectogel as a confined reaction medium using LED light.

Predicting selectivity and conversion in a confined reaction medium under photochemical conditions is highly challenging as compared to the corresponding conventional synthesis. Herein, we report the use of a simple carbohydrate-derived eutectogel to facilitate LED-light-induced regioselective synthesis of 4-arylamino-1,2-naphthoquinones in good yield. This methodology, by including a reusable reaction medium, proved to have the potential of affording the regioselective formation of various desired products in good yields.

Ethnoveterinary practises of medicinal plants used for the treatment of different cattle diseases: A case study in East Khasi Hill district of Meghalaya, North East India.

Introduction: For generations, the inhabitants of Meghalaya have relied on medicinal plants to maintain the health of their livestock and treat various illnesses that may afflict their animals. Due to the lack of survey for use and documentation, these plants have never been undertaken. Therefore, it is imperative to explore the diversity, utilization, and phytochemical profile of these plants and quantitatively analyse the data to identify important medicinal plants.

Self-Assembling Nanoarchitectonics of Twisted Nanofibers of Fluorescent Amphiphiles as Chemo-Resistive Sensor for Methanol Detection.

The inhalation, ingestion, and body absorption of noxious gases lead to severe tissue damage, ophthalmological issues, and neurodegenerative disorders; death may even occur when recognized too late. In particular, methanol gas present in traces can cause blindness, non-reversible organ failure, and even death. Even though ample materials are available for the detection of methanol in other alcoholic analogs at ppm level, their scope is very limited because of the use of either toxic or expensive raw materials or tedious fabrication procedures.

Electronically Robust Self-Assembled Supramolecular Gel as a Potential Material in Triboelectric Nanogenerators.

A series of self-assembling gluconamide conjugated naphthalimide amphiphiles (GCNA) was synthesized and the self-assembly of GCNA into gel rendered an increased electron density in naphthalimide moiety with an overall change in energy of 15.33×10  J via J-type aggregation. SEM analysis and X-ray diffraction underpinning the nanofibrillar formation, and rheological measurements confirmed the processablity and material fabrication.

Functionalized nanoparticles: Tailoring properties through surface energetics and coordination chemistry for advanced biomedical applications.

Significant advances in nanoparticle-related research have been made in the past decade, and amelioration of properties is considered of utmost importance for improving nanoparticle bioavailability, specificity, and catalytic performance. Nanoparticle properties can be tuned through in-synthesis and post-synthesis functionalization operations, with thermodynamic and kinetic parameters playing a crucial role. In spite of robust functionalization techniques based on surface chemistry, scalable technologies have not been explored well.

Domino Synthesis of Thiazolo-Fused Six- and Seven-Membered Nitrogen Heterocycles via Intramolecular Heteroannulation of In-Situ-Generated 2-(Het)aryl-4-amino-5-functionalized Thiazoles.

Synthesis of novel 2-(het)aryl-substituted thiazolo-fused six- and seven-membered heterocycles, such as thiazolo[4,5-]pyridin-5(4)-ones, thiazolo[4,5-]isoquinolin-5(4)-ones, thiazolo[4,5-]quinolin-9(4)-ones, 4-benzo[]thiazolo[4,5-]azepine-5,10-diones, have been developed in a single-pot operation via intramolecular heteroannulation of in-situ-generated 2-(het)aryl-4-amino-5-functionalized thiazoles. These 4-amino-5-functionalized thiazoles were readily obtained in a one-pot process by treatment of a range of (het)aryldithioesters with cyanamide in the presence of NaH, followed by in situ -alkylation-intramolecular condensations of the resulting thioimidate salts with appropriate activated methylene halides. On the other hand, the corresponding 4-benzo[]thiazolo[4,5-][1,4]diazepin-10(9)-ones were synthesized in a two-step process, requiring prior isolation of 5-carboethoxy-4-(2-nitrophenyl)aminothiazoles and their subsequent reductive cyclization.

Effect of nitrogen and zinc nanofertilizer with the organic farming practices on cereal and oil seed crops.

Sustainable and precision agriculture practices are essential to meet the global food demand with minimal impact on soil, air and water. In the present study, nanofertilizers of nitrogen and zinc was used with the organic farming practice under field condition for the cereal i.e.

Single-Pot Preparation of 4-Amino-2-(het)aryl-5-Substituted Thiazoles Employing Functionalized Dithioesters as Thiocarbonyl Precursors.

An effective, diversity oriented, one-pot reaction of 4-amino-2-(het)aryl/alkyl-5-functionalized thiazoles has been disclosed, utilizing aryl/heteroaryl/alkyl dithioesters as thiocarbonyl coupling partners in a modified Thorpe-Ziegler type cyclization. The reaction proceeds at room temperature, under mild conditions, in excellent yields, displaying broad functional group compatibility at 2 and 5 positions of thiazoles. This synthetic strategy has been further expanded for the one-pot construction of two highly potent tubulin polymerization inhibitors, i.

Monte Carlo-based dosimetric studies of a locally developedTm LDR brachytherapy seed source.

Tm is being explored as a source for applications in brachytherapy. Although it has adequate physical properties, such as a short half-life (128.6 d), high specific activity and a mean photon energy of about 66 keV, it has a drawback of low photon yield (only about six photon emissions/100 beta emissions).

Synthesis of Substituted Benzo[]thiophenes via Base-Promoted Domino Condensation-Intramolecular C-S Bond Formation.

A novel synthesis of 2,3-substituted benzothiophenes is reported, involving a tandem base-mediated condensation of -iodoarylacetonitriles/acetates/ketones with (hetero)aryldithioesters and an intramolecular C-S bond formation. The reaction affords diversely substituted benzothiophenes and heterofused thiophenes in excellent yields.

Naphthalenediimides with High Fluorescence Quantum Yield: Bright-Red, Stable, and Responsive Fluorescent Dyes.

The naphthalenediimide (NDI) scaffold in contrast to its higher congeners possess low-fluorescence. In spite of elegant synthetic developments, a highly emissive NDI is quite rare to find, as well as, a green-light-emitting NDI is yet to be explored. Herein, we report a novel class of symmetric and asymmetric NH -substituted core-NDIs (1-5) with tunable fluorescence in the visible region and extending to the NIR frontier.

Halogen-Bonded Assemblies of Arylene Imides and Diimides: Insight from Electronic, Structural, and Computational Studies.

Halogen-bonding interactions in electron-deficient π scaffolds have largely been underexplored. Herein, the halogen-bonding properties of arylene imide/diimide-based electron-deficient scaffolds were studied. The influence of scaffold size, from small (phthalimide) to moderately sized (pyromellitic diimide or naphthalenediimides) to large (perylenediimide), axial-group modification, and number of halo substituents on the halogen bonding and its self-assembly was probed in a set of nine compounds.

Domino Synthesis of 2-Substituted Benzothiazoles by Base-Promoted Intramolecular C-S Bond Formation.

A new, transition-metal-free, domino synthesis of 2-substituted benzothiazoles has been developed, involving base-promoted one-pot addition of active methylene compounds to -iodoarylisothioacyanates and subsequent intramolecular C-S bond formation of the resulting thioamidate anion. The reaction proceeds at room temperature within 1-3 h, affording diversely substituted benzothiazoles in high yields. A possible radical intermediate pathway, via an S1 mechanism, has been proposed for intramolecular C-S bond formation.

Doubly zwitterionic, di-reduced, highly electron-rich, air-stable naphthalenediimides: redox-switchable islands of aromatic-antiaromatic states.

The di-reduced state of the naphthalene moiety and its congeners have long captivated chemists as it is elusive to stabilize these intrinsically reactive electron-rich π-systems and for their emergent multifaceted properties. Herein we report the synthesis and isolation of two-electron (2e) reduced, highly electron-rich naphthalenediimides (NDIs). A doubly zwitterionic structure is observed for the first time in a naphthalene moiety and validated by single crystal X-ray crystallography and spectroscopic methods.

Myelitis: A Rare Presentation of Epstein Barr Virus.

EBV associated nervous system complications includes encephalitis, meningitis, cerebellitis, polyradiculomyelitis, transverse myelitis, cranial and peripheral neuropathies, and psychiatric abnormalities are usually more commonly seen in immunocompromised patients and rarely in immunocompetent patients. Here we are reporting a 13 years old boy developed headache, malaise, sore throat and low back pain with radiation to both lower limbs. Next day he felt numbness below umbilicus followed by acute onset weakness in both lower limbs and urinary retention.

Synthesis and Isolation of a Stable Perylenediimide Radical Anion and Its Exceptionally Electron-Deficient Precursor.

The synthesis and isolation of an ambient stable perylenediimide radical anion is reported, and its precursor is established as one of the strongest electron acceptors. The radical anion shows absorption up to 1400 nm and is stable in mixed aqueous solution. Interestingly, the radical anion can organize two electron-deficient molecules over its surface to form a π-stacked array.