Phytochemical analysis and antioxidant potential of and against HO-induced cytotoxicity in PC3 cells.

The management of oxidative stress-related disorders has garnered significant interest, particularly in the exploration of medicinal plants possessing potent antioxidant activities. This study was undertaken to evaluate the antioxidant activity of (MW) and (GT) against HO-induced cytotoxicity in PC3 cells. The phytochemical composition of MW and GT was determined by GC-MS analysis.

Unveiling the Structural Characteristics and Bioactivities of the Polysaccharides Extracted from Endophytic sp.

Polysaccharides are abundantly present in fungi and are gaining recognition for their exceptional bioactivities. Hence, the present study aimed to extract intracellular polysaccharides (IPS-1 and IPS-2) from the endophytic and compare their physicochemical and bioactive attributes. The monosaccharide composition analysis revealed the existence of galactose, glucose, and mannose in both the IPS, while a trace amount of xylose was found in IPS-1.

Research progress in green synthesis of manganese and manganese oxide nanoparticles in biomedical and environmental applications - A review.

Nanomaterials and nanotechnology have proven unassailable positions for environmental remediation and medicine. Currently, global environmental pollution and public health problems are increasing and need to be urgently addressed. Manganese (Mn) is one of the essential metal elements for plants and animals, it is necessary to integrate with nanotechnology.

Biodegradation of dibutyl phthalate in liquid fermentation by endophytic Penicillium species and the toxicity evaluation of the by-product.

The production and use of dibutyl phthalate (DBP) are increasing, and the resulting health and environmental problems are of concern. Therefore, the present study focused on the biodegradation of DBP in liquid fermentation using endophytic Penicillium species and evaluated the cytotoxic, ecotoxic, and phytotoxic effects of the fermented filtrate (by-product). Higher biomass yield was observed in fungal strains grown in DBP-containing media (DM) compared to DBP-free (control) media (CM).

Ampicillin-resistant bacterial pathogens targeted chitosan nano-drug delivery system (CS-AMP-P-ZnO) for combinational antibacterial treatment.

Drug-resistant microorganisms are defeated using combinational drug delivery systems based on biopolymer chitosan (CS) and metal nanoparticles. Hence, PEGylated zinc oxide nanoparticles (P-ZnO NPs) decorated chitosan-based nanoparticles (CS NPs) were prepared to deliver ampicillin (AMP) for improved antibacterial activity. In comparison to ZnO NPs, P-ZnO NPs exhibit less aggregation and more stable rod morphologies in TEM.

Comparative Analysis of the Antioxidant, Antidiabetic, Antibacterial, Cytoprotective Potential and Metabolite Profile of Two Endophytic spp.

The current study assessed the metabolite abundance, alpha (α)-amylase and α-glucosidase inhibitory, antioxidant, and antibacterial activity of the ethyl acetate extract (EAE) of endophytic (PL) and (PR). A higher extract yield was found in EAE-PR with a total phenolic content of 119.87 ± 3.

Antioxidant and Antibacterial Effects of Potential Probiotics Isolated from Korean Fermented Foods.

A total of sixteen bacterial strains were isolated and identified from the fourteen types of Korean fermented foods that were evaluated for their in vitro probiotic potentials. The results showed the highest survivability for Bacillus sp. compared to Lactobacillus sp.

Impact of environmental phthalate on human health and their bioremediation strategies using fungal cell factory- A review.

Phthalates are utilized as plasticizers in plastic products to enhance their durability, transparency, and elasticity. However, phthalates are not covalently bonded to the polymer matrix of the phthalate-containing products and can be gradually released into the environment through biogeochemical processes. Hence, phthalates are now pervasive in our environment, including our food.

Human Fungal Infection, Immune Response, and Clinical Challenge-a Perspective During COVID-19 Pandemic.

Fungi are a small but important part of the human microbiota and several fungi are familiar to the immune system, yet certain can cause infections in immunocompromised hosts and referred as opportunistic pathogens. The fungal coinfections in COVID-19 hosts with predisposing conditions and immunosuppressive medications are posing higher severity and death. The immunological counteraction (innate/adaptive immunity) is triggered when the PRRs on the host cells recognize the fungal PAMPs.

Enhancement of anti-bacterial potential of green synthesized selenium nanoparticles by starch encapsulation.

This study established a cost-effective and environmentally friendly approach to synthesizing the selenium nanoparticles using Artemisia annua (AaSeNPs) and encapsulating the starch (StAaSeNPs) for enhanced anti-bacterial activity. The UV-vis spectra displayed an absorption maxima at 278 nm corresponding to surface plasmon resonance of SeNPs. Particle size were found 70.

Combination of Paraconiothyrium brasiliense fabricated titanium dioxide nanoparticle and antibiotics enhanced antibacterial and antibiofilm properties: A toxicity evaluation.

Antimicrobial resistance (AMR) causes global consequences through increased mortality and economic loss. Antimicrobial drugs including nanomaterials are an emerging environmental impact. Hence, this work aimed to synthesize and characterize the titanium dioxide nanoparticles (TiO NPs) using the aqueous extract of endophytic fungus Paraconiothyrium brasiliense (Pb) for enhancing the antibacterial efficiency of existing standard antibiotics at minimum concentration.

Unraveling the hazardous impact of diverse contaminants in the marine environment: Detection and remedial approach through nanomaterials and nano-biosensors.

Marine pollution is one of the most underlooked forms of pollution as it affects most aquatic lives and public health in the coastal area. The diverse form of the hazardous pollutant in the marine ecosystem leads the serious genetic level disorders and diseases which include cancer, diabetes, arthritis, reproductive, and neurological diseases such as Parkinson's, Alzheimer's, and several microbial infections. Therefore, a recent alarming study on these pollutants, the microplastics have been voiced out in many countries worldwide, it was even found to be in the human placenta.

Impact of benzo[a]pyrene with other pollutants induce the molecular alternation in the biological system: Existence, detection, and remediation methods.

The exposure of benzo [a]pyrene (BaP) in recent times is rather unavoidable than ever before. BaP emissions are sourced majorly from anthropogenic rather than natural provenance from wildfires and volcanic eruptions. A major under-looked source is via the consumption of foods that are deep-fried, grilled, and charcoal smoked foods (meats in particular).

A comprehensive review on immuno-nanomedicine for breast cancer therapy: Technical challenges and troubleshooting measures.

Nanosized drug carriers have received a major attention in cancer therapeutics and theranostics. The immuno-nanomedicine is a combination of monoclonal antibody (mAb)/mAb-drug-nanoparticles. The immuno-nanomedicine offers a promising strategy to target cancer cells.

Discovery and Functional Evaluation of Antimicrobials.

Microbial infections pose a continuous threat to human health and healthcare systems around the globe [...