Trace metal accumulations in commercially important fish and crab species from impacted tropical estuary, India: implications on human health risk assessment.

Despite the beneficial role of aquatic food, bioaccumulation of trace metals can increase health risk for consumers. We conducted a comprehensive study to understand the levels of various trace metals (Cd, Co, Cr, Cu, Fe, Ni, Pb, Zn and Mn) in fish (Nematalosa nasus, Gerres filamentosus, Arius arius, Gerres erythrourus, Sardinella fimbriata, Caranx ignobilis, Etroplus suratensis, Mugil cephalus, Sillago sihama, and Euryglossa orientalis) and crab (Portunus pelagicus and Scylla serrata) species collected from Netravathi-Gurupur estuary, India and evaluated the potential health risks to humans by measuring target health hazard (THQ), hazard index (HI), estimated daily (EDI) and weekly (EWI) intake and cancer risk (CR). The hierarchy of toxic metal content in studied species was Fe>Pb>Cr>Mn>Zn>Cu>Ni>Cd>Co.

Exposure to environmentally relevant concentrations of di-(2-ethylhexyl) phthalate (DEHP) induced reproductive toxicity in female koi carp (Cyprinus carpio).

A frequently utilized plasticizer is di-(2-ethylhexyl) phthalate (DEHP), considered a ubiquitous contaminant in the environment and reported to have severe impacts on animals. Although it disrupts the female reproductive system in mammals, little is known about how it effects on fish reproduction. The reproductive parameters of female adult koi carp (Cyprinus carpio) were investigated in this study subjected to environmentally relevant exposure of DEHP (1, 10 and 100 μg/L).

Reactivity Study of the Bis(phosphine)-Stabilized Antimony(I) Cation.

The 5,6-Bis(diisopropylphosphino)acenaphthene -stabilized Sb(I) cationic compound [LSb][OTf] (OTf = CFSO) possessing two lone pairs of electrons on the Sb(I) center showed nucleophilic behavior toward methyl trifluoromethanesulfonate forming the oxidized product [LSbMe][OTf] (OTf = CFSO). Reaction of compound with Lewis acids such as GaCl and AlBr led to changes in the counteranions only giving products [LSb][GaCl] and [LSb][SbBr] , respectively. A metathesis reaction was observed when compound was reacted with PI.

Removal of organic pollutants from paper mill effluent using Taro (Colocasia esculenta L. Schott) in an electro-assisted horizontal subsurface flow constructed wetland: Experimental and kinetic studies.

In this study, the phytoremediation potential of Taro (Colocasia esculenta L. Schott) plant was examined, utilizing horizontal subsurface flow constructed wetlands with and without an electric current supply for the purpose of removing pollutants from paper mill effluent. For this, different wetlands were set up with varying concentrations of effluent: CW (Control), CW1 (25%), CW2 (50%), CW3 (75%), CW4 (100%).

Biomedical prospects and challenges of metal dichalcogenides nanomaterials.

The biomedical applications of metal dichalcogenides (MDCs) nanomaterials (NMs) are an emerging discipline because of their unique attributes like high surface-to-volume ratio, defect sites, superb catalytic performance, and excitation-dependent emission, which is helpful in bio-imaging and cancer cell killing. Due to the compatibility of sensing material with cells and tissues, MoS, WS, and SnSNMs have piqued the interest of researchers in various biomedical applications like photothermal therapy used in killing cancer cells, drug delivery, photoacoustic tomography (PAT) used in bio-imaging, nucleic acid or gene delivery, tissue engineering, wound healing, etc. Furthermore, these NMs' functionalization and defect engineering can enhance therapeutic efficacy, biocompatibility, high drug transport efficiency, adjustable drug release, dispersibility, and biodegradability.

Design, Synthesis, Anti-Proliferative, and Apoptotic Assessment of Spirocyclopropyl Oxindole-Isatin Hybrids on Triple-Negative Breast Cancer.

A series of 1H-1,2,3-triazole-tethered spirocyclopropyl oxindole-isatin hybrids were synthesized using a copper-promoted click reaction and evaluated for their anti-proliferative activities against triple-negative breast cancer cell lines. The most potent compound in the series outperformed tamoxifen and 5-fluorouracil, with selectivity indices of 1.60 and 1.

Evolution of antisense oligonucleotides: navigating nucleic acid chemistry and delivery challenges.

Introduction: Antisense oligonucleotide (ASO) was established as a viable therapeutic option for genetic disorders. ASOs can target RNAs implicated in various diseases, including upregulated mRNA and pre-mRNA undergoing abnormal alternative splicing events. Therapeutic applications of ASOs have been proven with the Food and Drug Administration approval of several drugs in recent years.

Child Oral Health Impact Profile Questionnaire: A Reliability Generalization Meta-analysis of Cronbach's Alpha.

Background And Aim: To evaluate the pooled estimates of Cronbach's alpha for the Child Oral Health Impact Profile (COHIP) questionnaire using reliability generalization meta-analysis.

Methods: We have conducted a systematic search of literature from PubMed, Scopus, Excerpta Medica Database (EMBASE), and Cumulative Index to Nursing and Allied Health Literature (CINAHL) from inception till 31 May 2023. Studies in English and those that have reported Cronbach's alpha for the COHIP questionnaire were included.

Construction of five- and seven-membered rings facilitated by alkyne-azide functionality: access to quinoline fused triazolo-azepines.

The synthesis of novel quinoline-fused triazolo-azepine derivatives has been reported using an intramolecular 1,3-dipolar azide-alkyne cycloaddition strategy. This method possesses considerable potential to synthesize five- and seven-membered rings in high yields (65-87%) without the necessity of metal catalysts or additives. Additionally, this methodology was applicable to pyridine and tetralone based adducts to afford triazolo-azepine derivatives.

Thrips wedeliae (Priesner) (Thysanoptera: Thripidae) new to India: first description of the male.

Thrips wedeliae (Priesner) was originally described based on a single female from Java, Indonesia. Recently, we have collected males and females of this species from Solanum mauritianum in Uttarakhand state, India. Here, males of T.

A new species of the genus Ceraphron Jurine (Hymenoptera: Ceraphronidae) from India.

Ceraphron initium sp. nov. is described and illustrated from Nagaland state of India based on male specimens.

Ruxolitinib-dependent reduction of seizure load and duration is accompanied by spatial memory improvement in the rat pilocarpine model of temporal lobe epilepsy.

Molecules with optimized pharmacokinetic properties selectively aimed at the inhibition of STAT3 phosphorylation in brain have recently emerged as potential disease modifying therapies for epilepsy. In the current study, pharmacological inhibition of JAK1/2 with the orally available, FDA-approved drug ruxolitinib, produced nearly complete inhibition of hippocampal STAT3 phosphorylation, and reduced the expression of its downstream target Cyclin D1, when administered to rats 30 ​min and 3 ​h after onset of pilocarpine-induced status epilepticus (SE). This effect was accompanied by significantly shorter seizure duration and lower overall seizure frequency throughout the 4 weeks of EEG recording, but did not completely prevent the development of epilepsy in ruxolitinib-treated male rats.

Chiroptical Amplification of [7]-Helicene Nanographene by Additional Helical Chirality.

Nanographenes have captivated scientific interest since the pioneering discovery of graphene. Recently, attention has shifted towards exploring chiral and nonplanar nanographenes, for their distinct optical, chiroptical, and electronic properties. Despite the growing acceptance of helicenes, the research on inducing helical chirality on π-extended derivatives to boost chiroptical properties remains unattended.

A systematic review of developments in gripper technologies for rigid fabric parts.

This paper presents an inquiry of scholarly literature published in the last decade pertaining to the development of robot grippers for compressed fabric parts, which are both rigid and porous. The study is narrow and targeted. Previous literature reviews investigating technologies suitable for materials with similar properties were analysed, and the need for recent works addressing stiff and simultaneously permeable materials was identified.

Investigating the mechanical properties and crashworthiness of hybrid PLA/GFRP composites fabricated using FDM-filament winding.

The failure and crashworthiness performance of hybrid Polylactide (PLA)/Glass Fiber Reinforced Polymer (GFRP) composite tubes subjected to axial and radial quasistatic compression loads were investigated in the present study. The composite tubes are fabricated using hand lay-up and Fused Deposition Modeling (FDM)-filament winding processes. The crashworthiness performance was studied using parameters such as the peak load, energy absorption, crush load, crushing load efficiency, and specific energy absorption.

Measles and rubella seroprevalence in adults using residual blood samples from health facilities and household serosurveys in Palghar District, Maharashtra, India, 2018 - 2019.

Residual blood specimens collected at health facilities may be a source of samples for serosurveys of adults, a population often neglected in community-based serosurveys. Anonymized residual blood specimens were collected from individuals 15 - 49 years of age attending two sub-district hospitals in Palghar District, Maharashtra, from November 2018 to March 2019. Specimens also were collected from women 15 - 49 years of age enrolled in a cross-sectional, community-based serosurvey representative at the district level that was conducted 2 - 7 months after the residual specimen collection.

Purification and characterization of kyasanur forest disease virus EDIII domain of major envelope glycoprotein.

Current research efforts are underway to create novel approaches for the efficient diagnosis, monitoring, and mitigation of Kyasanur Forest Disease Virus (KFDV) infections. Flavivirus subunit-based vaccines based on envelope glycoprotein EDIII are now in preclinical and clinical research stages. Efficient purification and isolation methods for surface immunogenic viral antigens, including the recombinant envelope immunoglobulin-like domain III (rEDIII) protein, are crucial for the production and manufacturing of promising vaccine candidates that have been extensively assessed in previous literature.

Understanding current trends and incidence projections of prostate cancer in India: A comprehensive analysis of national and regional data from the global burden of disease study (1990 -2021).

Background: The study aims to explore the burden and trends of prostate cancer (PC) in India at the state level from 1990 to 2021, using data from the Global Burden of Disease (GBD) 2021 study.

Methods: The health metrics including age-standardised incidence rates (ASIR), prevalence rates (ASPR), disability-adjusted life years (ASDR), and mortality rates (ASMR) per 100,000 for PC were analysed across Indian states and union territories. Join point regression analysis was employed to identify significant changes in these metrics over time.

Identification of HLA-B*13:01:01:12 by Next Generation Sequencing in Indian Population.

HLA-B*13:01:01:12 differs from HLA-B*13:01:01:01 by a single nucleotide.