Exploration of compositional, functional, nutraceutical, and metabolites of Ram kandmool (Agave sisalana Perrine) for potential application in food systems.

The present study examined the food value, techno-functional properties, and potential metabolites of Agave sisalana Perrine (Ram kandmool, RKM) flour. The proximate analysis revealed that RKM flour has a moisture content (10.74 %), fat content (1.

Vonoprazan in Management of Refractory Gastroesophageal Reflux Disease: An Indian Expert Group Consensus Statements.

Background: Approximately, 40% of gastroesophageal reflux disease (GERD) patients experience insufficient symptom relief from proton-pump inhibitors (PPI), resulting in PPI-refractory GERD (rGERD).

Objective: To review the existing literature and develop an Indian expert group consensus statement on the place of vonoprazan in the management of rGERD.

Materials And Methods: A panel of 35 leading Indian gastroenterologists extensively reviewed the literature to develop consensus statements for the management of rGERD in Indian patients, with a focus on the newly available potassium-competitive acid blocker (P-CAB), vonoprazan.

Genome editing research initiatives and regulatory landscape of genome edited crops in India.

Food and nutritional security are the top priorities in Indian agriculture. Exponential population growth coupled with climate change effects has become a serious challenge for sustainable agriculture. Genome editing has revolutionized the agricultural sector because of its ability to create precise, stable and predictable modifications in the genome and therefore, offers great opportunities for crop improvement in India.

Neuropeptide-Dependent Spike Time Precision and Plasticity in Circadian Output Neurons.

Circadian rhythms influence various physiological and behavioral processes such as sleep-wake cycles, hormone secretion, and metabolism. In Drosophila, an important set of circadian output neurons is called pars intercerebralis (PI) neurons, which receive input from specific clock neurons called DN1. These DN1 neurons can further be subdivided into functionally and anatomically distinctive anterior (DN1a) and posterior (DN1p) clusters.

Morin hydrate treatment minimizes Di(2-ethylhexyl) phthalate-induced uterine fibrosis, oxidative stress, and apoptosis in mice.

Background: Di (2-ethylhexyl) phthalate (DEHP), a widely used chemical in plastics, has various health hazards when accumulated in the environment. DEHP has been shown to cause toxicity to various organs like the liver, kidney, and reproductive organs. Phytocompounds have been used to mitigate DEHP-mediated organ toxicity.

Conventional Coagulation Tests are a better predictor of mortality than Viscoelastic Haemostatic Assays in trauma patients with shock: a prospective observational study.

Purpose: Conventional Coagulation Tests (CCTs) and Viscoelastic Haemostatic Assays (VHAs) are currently used in guiding trauma resuscitation. However, the role of these tests in predicting mortality is less known. This study aims to analyze both CCTs and VHAs in predicting mortality.

Distinct features of a peripheral T helper subset that drives the B cell response in dengue virus infection.

Dengue-virus-induced humoral immunity can increase the risk of severe disease, but the factors influencing this response are poorly understood. Here, we investigate the contribution of CD4 T cells to B cell responses in human dengue infection. We identify a dominant peripheral PD-1 T cell subset that accumulates in severe patients and could induce B cell differentiation via interleukin-21 (IL-21)-related pathway.

Paediatric Head and Neck Hemangiomas: Scopes, Challenges and Outcome of Surgical Management.

Haemangiomas are benign vascular tumours frequently encountered in head and neck region. The different systems of nomenclature leading to terminological confusion and management protocols for vascular lesions have been contentious issues and have undergone substantial paradigm shift over the years. A policy has been the mainstay of treatment owing to spontaneous regression of majority of paediatric hemangiomas along with sclerotherapy, laser therapy, drug therapy and radiotherapy.

Efficacy and safety of platelet-rich plasma as an adjunct therapy to split thickness skin graft in burn patients with granulating raw wounds: a prospective, randomized, double-blind study-study protocol.

Background: Burn wounds are commonly encountered in clinical settings and the management aims at the prevention of mortality and morbidity due to disability. The platelet-rich plasma (PRP) is blood-derived biomaterial that is enriched with growth factors and cytokines that facilitate wound healing. The PRP has proven its efficacy in various other wounds, but its role in post-burn raw areas and graft take has not been validated.

Monitoring and risk assessment for pesticide residues in vegetables, soil, and water in Haryana, India.

The present study was conducted with the aim to identify estimates and risk assessment for the pesticide residue present in vegetables, soil, and water in Haryana, India. In the present study, environmental monitoring of commonly sprayed 161 pesticides was done using liquid chromatography-tandem mass spectrometry and gas chromatography-tandem mass spectrometry for 102 vegetables, 46 soil, and 50 water samples collected from four districts in Haryana, India. A total of 198 samples were analyzed for the presence of pesticide residue and the measured pesticide concentrations were compared with the Maximum Residue Limit (MRL) set by the Food Safety and Standards Authority of India (FSSAI) and European regulations.

Challenges of Managing Lupus Nephritis in an Emerging Nephrology Centre: A Fijian Cohort Study.

Aim: To characterise the epidemiology and outcomes of Lupus Nephritis (LN) in Fiji.

Methods: All adult LN cases diagnosed from 2016 to 2020 at the national referral hospital were included. Treatment response, kidney failure, dialysis dependence and death were reported.

The Non-inferiority of Telemedicine in Pre-anesthesia Clinic at a Tertiary Cancer Care Center: A Randomized Study.

Background With the increasing demand for cancer care and advancements in digital health, telemedicine has emerged as a promising tool to enhance healthcare accessibility and efficiency. Its application in pre-anesthesia consultations (PAC) has the potential to address logistical challenges while maintaining clinical quality. Purpose This study assesses whether telemedicine is a non-inferior alternative to traditional face-to-face pre-anesthesia consultations (PAC) for cancer surgery patients at a tertiary care center and evaluates discrepancies between PAC findings and pre-surgical assessments.

Assessing the Impact of Skin Tone on Tooth Shade Selection: A Cross-Sectional Study.

Background: The role of skin tone in determining tooth shade preferences is crucial in aesthetic dentistry. This study aims to evaluate the impact of skin tone on tooth shade selection by comparing preferences between dental professionals and laypersons.

Methods: A cross-sectional study was conducted with 100 participants, including 50 dental specialists (prosthodontists and endodontists) and 50 laypersons (teachers, engineers, and business owners).

Fecal Microbiota Transplantation for Refractory Infection Post Haploidentical Transplant for Pediatric Acute Myeloid Leukemia.

Background: () infections are common in immunosuppressed patients. Sometimes these are difficult to treat in post-bone marrow transplant situations.

Methods: A 2-year-old child with relapsed acute myeloid leukemia underwent a haploidentical bone marrow transplant.

Herbal based nanoparticles as a possible and potential treatment of cancer: a review.

Cancer is the greatest cause of mortality worldwide. Various drug classes treat various cancers. Nanoformulations made from natural sources are being studied for treating several diseases, including cancer.

The Missing M Band: Is it Really Non Secretory Multiple Myeloma?

Background: Non-secretory multiple myeloma (NSMM) is defined as clonal bone marrow plasma cells ≥10% or biopsy proven plasmacytoma, evidence of end-organ damage due to underlying plasma cell dyscrasia, namely hypercalcemia, renal insufficiency, anaemia, bone lesions and lack of serum and urinary monoclonal protein on electrophoresis and immunofixation. They represent 3-5% of multiple myeloma (MM). With the advent of serum free light chain (s FLC) measurement, most of NSMMs have been classified as Light chain Multiple myeloma (LCMM).

Workshop Report-Heterogeneity and Successful Aging Part I: Heterogeneity in Aging-Challenges and Opportunities.

Historically, aging research has focused primarily on the study of differences in means of varied measures obtained at different ages. However, growing evidence has shown that for many parameters, variability in measurements obtained both between- and within-age groups increases with aging. Moreover, growing heterogeneity may become especially apparent when examined via longitudinal as opposed to cross-sectional aging data.

Structural insights, regulation, and recent advances of RAS inhibitors in the MAPK signaling cascade: a medicinal chemistry perspective.

The MAPK pathway has four main components: RAS, RAF, MEK, and ERK. Among these, RAS is the most frequently mutated protein and the leading cause of cancer. The three isoforms of the RAS gene are HRAS, NRAS, and KRAS.

Evaluation of one- versus two-step technique on the outcome of mineral trioxide aggregate pulpotomy in mature permanent teeth with symptomatic irreversible pulpitis.

Context: This study compares one-step and two-step mineral trioxide aggregate (MTA) pulpotomy techniques in treating symptomatic irreversible pulpitis (SIP) in mature molars over 12 months.

Aims: To compare the clinical efficacy of one-step versus two-step MTA pulpotomy in mature permanent teeth with SIP.

Setting And Design: This clinical trial involved 30 patients with SIP in mandibular molars, comparing one-step and two-step MTA pulpotomy.

Preliminary impact of an mHealth education and social support intervention on maternal health knowledge and outcomes among postpartum mothers in Punjab, India.

Background: Significant disruptions in the perinatal continuum of care occur postpartum in India, despite it being a critical time to optimize maternal health and wellbeing. Group-oriented mHealth approaches may help mitigate the impact of limited access to care and the lack of social support that characterize this period. Our team developed and pilot tested a provider-moderated group intervention to increase education, communication with providers, to refer participants to in-person care, and to connect them with a virtual social support group of other mothers with similarly aged infants through weekly calls and text chat.

Construction and characterization of cloning vector and temperature sensitive vectors for Gordonia sp. IITR100.

Gordonia spp. are Gram-positive, non-sporulating bacteria which have several industrial as well as environmental applications. In order to enhance their potential, metabolic engineering is required which often involves genome manipulation.

Feasibility and outcomes of PCI with novel tapered coronary stent in people living with HIV: A prospective, single-center study with literature review.

Background And Objective: Patients with chronic HIV infection face a high risk of premature coronary atherosclerosis, partly due to continuous HAART therapy and susceptibility to opportunistic infections, complicating percutaneous coronary intervention (PCI). HIV patients have unique coronary vasculature characteristics. This study aimed to assess the clinical outcomes of PCI using the novel tapered sirolimus-eluting coronary stent (SES) system in HIV patients.