Rheology of Ring Copolymers in Dilute Solutions.

We investigate the rheology of ring copolymers theoretically within the framework of the optimized Rouse-Zimm theory in dilute solutions. The ring copolymer is composed of two type of monomers (A and B) of different sizes (A < B), which is represented by unequal-sized beads connected via harmonic springs with different spring constants. The hydrodynamic interactions (HI) between the monomers is modeled using the preaveraged HI tensor.

Microwave-assisted synthesis of base-modified fluorescent 1,4-dihydropyridine nucleosides: photophysical characterization and insights.

A synthesis of a small library of fluorescent 1,4-dihydropyridine nucleoside analogues has been successfully carried out under solvent-free conditions a one-pot three-component Hantzsch condensation reaction. The process involved a Ba(NO) catalyzed solvent-free reaction between 3',5'-di--acetyl-5-formyl-2'-deoxyuridine, differently substituted β-keto ester and ammonium acetate under microwave irradiation. This facile methodology yielded the desired products with very high yields (86-96%) under solvent-free reaction conditions in a short reaction time, which was followed by a simple workup.

Tuning emissive color of trivalent terbium ion through environmental factors: optoelectronic insights from theoretical, spectral and computational studies.

The combination of 4,4,4-trifluoro-1-phenyl-1,3-butanedione (TFPB) and pyrazine (pyz) with Tb ions forms two distinct types of complexes, represented by the formulas [Tb(TFPB)(L)], where L is either HO or pyz, and [(Tb(TFPB))pyz]. A detailed examination of the impact of the surrounding environment on the photophysical properties of these synthesized complexes was conducted. Photoluminescence (PL) analysis indicated that the magnetic dipole transition (D → F) is dominant in Tb(iii)-based systems.

Adult Primary Central Nervous System Atypical Teratoid/Rhabdoid Tumor Metastasizing to the Cervical Lymph Node.

Atypical teratoid/rhabdoid tumors (AT/RTs) of the central nervous system (CNS) are rare and aggressive, typically occurring in early childhood or infancy, with adult cases being extremely rare. These tumors are associated with the inactivation of the integrase interactor 1 (INI1) gene. The prognosis is poor, worsening significantly if metastasis is detected at diagnosis.

Predictors of citations and altmetric scores in general surgery literature.

Objectives: This study aimed to determine various article characteristics influencing the citations and altmetric scores using papers published in a year in four high-ranking surgery journals.

Material And Methods: We included all papers (n= 819 articles) published between January 2015 to December 2015 in the Annals of Surgery, British Journal of Surgery, JAMA Surgery and Journal of American College of Surgeons. Article characteristics were manually extracted.

A Comprehensive Exploration of the Synergistic Relationship between DMSO and Peroxide in Organic Synthesis.

In the realm of organic synthesis, reagents can serve not only as solvents but also as synthons. Dimethyl sulfoxide (DMSO) is recognized for its efficiency in this dual capacity, enabling diverse chemical transformations. DMSO can generate various synthons, including methyl, methylene, methine, oxygen, and methyl sulfoxide, broadening the accessible compound repertoire.

A qualitative study to explore traffic police personnel perceptions towards road safety behaviour among young riders in Manipal, India.

Road crash injuries are significant public health issues in many low-and middle-income countries. Every year more than 1.35 million people lose their lives due to road crashes, making it one of the leading causes of death worldwide.

Shape-controlled, water-assisted synthesis of 2D luminescent CsPbBr perovskite microcrystals for highly responsive UV detectors.

Cesium-lead-halide (Cs-Pb-Br) perovskites have been a point of interest for researchers since their discovery for their extraordinary optical and electronic properties. Unlike other members of the Cs-Pb-Br family, CsPbBr is less explored. Herein, we synthesized 2D CsPbBr in an aqueous medium under ambient conditions.

Synthesis and Evaluation of Fluorinated Piperazine-Hydroxyethylamine Analogues as Potential Antiplasmodial Candidates.

In this manuscript, twenty-one novel fluorinated piperazine-hydroxyethylamine analogues were synthesized and tested against Plasmodium falciparum (Pf). Among tested compounds, two 13 g and 14 g exhibited promising inhibitory activity on Pf3D7 with IC values of 0.28 and 0.

Medical Doctors' Perceptions of Artificial Intelligence (AI) in Healthcare.

Introduction With the current exponential expansion of robotics, implants, and imaging technologies, diagnostic processes within the healthcare industry are becoming popular platforms for artificial intelligence (AI) use. Thus, an understanding of physicians' attitudes toward AI and the extent to which medical educators are ready to work with AI is necessary. This research aimed to study doctors' perceptions of AI in healthcare.

Recent Advances in the Synthesis of Acyclic Nucleosides and Their Therapeutic Applications.

DNA is commonly known as the "molecule of life" because it holds the genetic instructions for all living organisms on Earth. The utilization of modified nucleosides holds the potential to transform the management of a wide range of human illnesses. Modified nucleosides and their role directly led to the 2023 Nobel prize.

Functionalization of cellulose nanocrystals with a potent antimalarial compound: Synthesis, characterization, and biological studies.

Cellulosic materials, such as cellulose nanocrystals (CNCs), are biocompatible, biodegradable and have unique and fascinating biomedical applications. Calxinin (CXN), a potent multistage antimalarial compound was functionalised with CNCs to improve biocompatibility and enhance the bioactivity of the resulting CNC-CXN nano-conjugate. Elemental analysis, powder X-ray, SEM, AFM, Infrared, and solid-state NMR spectroscopic techniques confirmed the composition of novel CNC-CXN nano-conjugate.

Oxaliplatin-induced transient ischemic attack (TIA): A rare presentation.

Oxaliplatin is a common drug used in the management of colorectal malignancies. Rare neurological side effects including amaurosis fugax, urinary retention, stroke, cranial nerve palsy, dysarthria, and dysphagia have been reported in the literature. Usually, such incidences are reported immediately after 1st dose of oxaliplatin infusion.

Electrowetting hysteresis on a deformable dielectric film.

Electrowetting on dielectric (EWOD) involves actuating droplets through electrical stimulus while the droplets lie on a dielectric layer that covers the electrode. In order to activate the droplet, a higher threshold voltage is required due to electrowetting hysteresis. The effect of a deformable dielectric layer and its thickness on electrowetting hysteresis has not been studied.

Targeting epigenetic regulation and post-translational modification with 5-Aza-2' deoxycytidine and SUMO E1 inhibition augments T-cell receptor therapy.

Background: Cellular immunotherapy using modified T cells offers new avenues for cancer treatment. T-cell receptor (TCR) engineering of CD8 T cells enables these cells to recognize tumor-associated antigens and tumor-specific neoantigens. Improving TCR T-cell therapy through increased potency and in vivo persistence will be critical for clinical success.

Predictors of outcome following two-stage revision total knee arthroplasty.

Purpose: Two stage revision arthroplasty remains the gold standard for peri-prosthetic joint infections of the knee. However, the functional outcomes of revision surgeries and the factors governing them require further investigation. The purpose of this study was to (a) evaluate impact of early and late stage I surgery and interval between stage I and stage II; (b) understand the impact of infecting organism and resistance; (c) to estimate long term survivorship and causes of failure.

Real-time sign language detection: Empowering the disabled community.

Interaction and communication for normal human beings are easier than for a person with disabilities like speaking and hearing who may face communication problems with other people. Sign Language helps reduce this communication gap between a normal and disabled person. The prior solutions proposed using several deep learning techniques, such as Convolutional Neural Networks, Support Vector Machines, and K-Nearest Neighbors, have either demonstrated low accuracy or have not been implemented as real-time working systems.

Robotic Assisted TKA achieves adjusted mechanical alignment targets more consistently compared to manual TKA without improving outcomes.

Introduction: Robotic total knee arthroplasty (rTKA), with its purported advantages of more accurate alignment, greater functional outcomes and patient satisfaction, is gaining popularity in patients undergoing TKA. The purpose of our study was to compare these parameters along with gait pattern and kneeling ability in a cohort of patients who underwent simultaneous TKA with manual instrumentation (mTKA) and rTKA in contralateral knees at a 1-year follow-up.

Methods: This was a retrospective review of 135 consecutive patients who underwent simultaneous bilateral TKA using robotic assistance on one side and manual instrumentation on the contralateral side between January 2022 and June 2022.

Comparative Analysis of Mouth Self-Examination Awareness Amongst Tobacco Users in Urban and Rural Populations.

Background: Oral cavity cancer is a growing concern, especially in developing countries like India, due to risk factors such as tobacco use, alcohol consumption, nutritional deficiencies, and spicy food intake. Early detection through screening and Mouth Self-examination (MSE) can significantly improve outcomes, but limited awareness and pain in advanced stages lead to delayed detection. This study aimed to assess the knowledge and practice of MSE among tobacco users in urban and rural populations.

Rev-erbα regulate neurogenesis through suppression of Sox2 in neuronal cells to regenerate dopaminergic neurons and abates MPP induced neuroinflammation.

Parkinson's disease is a progressive neurodegenerative disease that affects the motor and non-motor circuits of the brain. Currently, there are no promising therapeutic measures for Parkinson's disease, and most strategies designed to alleviate the Parkinson's disease are palliative. The dearth of therapeutic interventions in Parkinson's disease has driven attention in the search for targets that may augment dopamine secretion, promote differentiation towards dopaminergic neuronal lineage, or aid in neuroprotection from neuronal stress and inflammation, and prevent Parkinson's disease associated motor impairment and behavioural chaos.

Sodium Ion-Conducting Electrolytes Based on Chloroaluminate Ionic Liquids and δ-NaCl.

Sodium-containing ionic liquids are very promising candidates as ion-conducting materials in alternative to electrolytes based on lithium chemistry. Here we investigate a series of seven ionic liquids with formula (EMImCl/(AlCl))/(δ-NaCl) (0≤x≤0.74).

Improved Survival With Chemotherapy in Patients With Malignant Biliary Tract Obstruction After Percutaneous Transhepatic Biliary Drainage (PTBD).

Introduction Biliary tree stenting for malignant biliary tract obstructions is a routine modality for the relief of jaundice. Treatment is palliative in most circumstances. However, adequate reduction in bilirubin levels after percutaneous transhepatic biliary drainage (PTBD) may help to offer chemotherapy, which may improve survival in a limited number of cases.