Osteogenic Evaluation of 3D-printed PLA scaffolds Integrated with Khellin-loaded Chitosan-Alginate Sponges for Bone Tissue Engineering.

Bone tissue engineering (BTE) offers promising strategies for bone regeneration, yet the effective delivery of bioactive molecules remains a challenge. Khellin (KH), a plant-derived furanochromone, possesses various biological properties, though its potential in promoting osteogenesis has not been thoroughly investigated. In this study, 3D-printed polylactic acid (PLA) scaffolds were integrated with KH-loaded chitosan-alginate sponges (PLA/ALG/CS-KH) to facilitate controlled and sustained delivery of KH.