Publications by authors named "Kumar R Satish"

In today's scenario, many scientists and medical researchers have been involved in deep research for discovering the desired medicine to reduce the spread of COVID-19 disease. However, still, it is not the end. Hence, predicting the COVID possibility in an early stage is the most required matter to reduce the death risks.

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Herewith, we synthesized the new oxazolidines (SP-1, SP-2 and SP-3) by without using any withdrawing or donating substitution, and for these molecules we demonstrated CO₂ sensing properties in naked eye condition with different colors (yellow and magenta). All the dyes showed different colors in the presence and absence of CO₂ in ethanol solution with the concept of ring closing and opening. In UV-visible absorption spectrum all the compounds showed visible light absorptions after purging of CO₂.

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Herewith, we approached a synthesis of new biphenyl porphyrin derivative and confirmed its structure with H-NMR and C-NMR studies, FT-IR and mass analytical methods. The porphyrin derivative grafted with TiO₂ and the composite (PORBP-TiO₂) was further confirmed with different analytical techniques like diffuse reflectance spectra, XRD, FT-IR, XPS, SEM analysis. PORBP-TiO₂ was checked for photodegradation of methylene blue in visible light condition and degradation results were compared with bare TiO₂.

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In this research, we successfully synthesized three novel zinc phthalocyanines and applied for electrochemical and photo physical properties. These phthalocyanines are naphthoxy derivatives with methyl, benzyl and butyl-benzyl, with halo substitution (PCME, PCBN and PCBBN) and poses very good solubility in all industrial solvents. To check the preliminary results of LCD green color filter properties of these molecules, we taken the UV-Visible absorption and transmittance studies in Propylene glycol monomethyl ether acetate and achieved around 90% of transmittance in the region of 400-550 nm.

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Hydrophobic nindigo dyes were designed and successfully synthesized from indigo by reacting with substituted anilines in a simple route. Four nindigo dyes were fruitfully analyzed by H NMR C NMR, electronic and mass spectrometry. Here, we have firstly introduced these nindigo dyes into dyeing area for the dyeing of unmodified polypropylene fiber in aqueous medium.

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We have designed and synthesized novel symmetrical anthracene substituted zinc(II), copper(II), cobalt(II) and nickel(II) phthalocyanines (PC1, PC2, PC3 and PC4) in this work. For this synthesis, we started from base-catalysed aromatic displacement reaction of 4-nitrophthalonitrile with 9-hydroxyanthracene. The resulting four phthalocyanines (PCs) have been fully characterized by a series of spectroscopic methods including electronic absorption, elemental analysis, MALDI-TOF mass, and IR spectroscopy.

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Here novel phenanthrenoxy and pyrenoxy substituted phthalocyanines were synthesized and fully characterized by general spectroscopic methods such as elemental analysis, 1H NMR, MALDI-TOF, FT-IR, UV-Visible absorption. The aggregation property of these phthalocyanines was investigated in CHCl3 and Triton X. Furthermore, electrochemical and DFT calculations were performed for these molecules.

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Background/aims: Liver abscess is a significant health problem in developing countries and the complications associated with it are frequently fatal. Hence identification of these complications and anticipating the same will lead to reduction in the mortality and morbidity rate. Such a work will facilitate in identifying patients with risk of complications and will allow for planning of an early intervention.

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Candida glabrata is an opportunistic human pathogen known to cause systemic and vaginal candidiasis. Rapid detection of Candida glabrata is indispensable for appropriate selection of antifungal drugs for chemotherapy. The study describes a unique intein-containing DNA fragment for specific detection of C.

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New porphyrin sensitizers based on donor-π-acceptor (D-π-A) approach have been designed, synthesized, characterized by various spectroscopic techniques and their photovoltaic properties explored. N,N'-Diphenylamine acts as donor, the porphyrin is the π-spacer, and either carboxylic acid or cyanoacryclic acid acts as acceptor. All compounds were characterized by using (1)H NMR spectroscopy, ESI-MS, UV-visible emission spectroscopies as well as electrochemical methods.

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Article Synopsis
  • A diverse set of 2,6-cis piperidine derivatives was created and tested for anticancer effects on various cancer cell lines (A549, MCF7, DU145, and HeLa).
  • One particular compound showed notable promise, suggesting potential for further research.
  • This research could lead to the development of new cancer treatments based on these derivatives.
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The synthesis and functional characterization of an antibiofilm exopolysaccharide (EPS) from a probiotic Enterococcus faecium MC13 were investigated. The temperature of 35 °C, pH of 6.5, and salinity of 1-2% were found to be optimum for EPS production.

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The relationship between antioxidant and anticancer properties of probiotic bacterium strain Lactobacillus plantarum AS1 (AS1) in colon cancer induced by 1,2-dimethylhydrazine (DMH) has been studied. In this study, an increased level of lipid peroxide (LPO) products and increased activities of antioxidant enzymes (superoxide dismutase, catalase and glutathione-S transferase) and marker enzymes (alkaline phosphatase and acid phosphatase) in colon and plasma of cancer-bearing animals have been observed. AS1 was supplemented either before initiation or during initiation and selection/promotion phases of colon carcinogenesis and was found to be effective in altering lipid peroxidation and antioxidant enzyme activities and marker enzymes to a statistically significant level measured either in the colon and in the plasma.

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In this study, a statistics-based experimental design was utilised for the optimisation of a growth medium which possibly enhanced bacteriocin production by Streptococcus phocae PI80. Carbon, nitrogen sources and a bio-surfactant were first screened using a one variable at a time technique and scored for increasing yield production. The selected variables were further statistically optimised using response surface methodology with a central composite design.

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Background: Naturally occurring antimicrobial peptides are possibly the "next frontier" in infection prevention. Binding them to mesh could reduce the rate of mesh infections. This study identifies an antimicrobial agent capable of significant antibacterial activity when bound to mesh.

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Statistics-based experimental designs were used to develop a cost-effective medium for enhanced production of viable cells and bacteriocin by probiotic Enterococcus faecium MC13. Carbon, nitrogen, and mineral sources were first screened by one-variable-at-a-time (OVAT) methods. In order to increase yield production, the selected variables were further statistically optimized using response-surface methodology (RSM) with central composite design (CCD).

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