This study presented a novel derivative of the antitussive compound noscapine, named 9-3-Pyridyl noscapine (PYNos), to enhance its anticancer potential. Through in silico investigations, PYNos exhibited strong interactions with microtubules, inhibiting cancer cell proliferation both alone and in combination with docetaxel. Docking scores highlighted the affinity of PYNos -5.
View Article and Find Full Text PDFZirconium-based metal-organic frameworks (MOF) exhibiting 3D rhombohedral microcrystals were synthesized by the solvothermal method. The structure, morphology, composition, and optical properties of the synthesized MOF were carried out using different spectroscopic, microscopic, and diffraction techniques. Synthesized MOF was rhombohedral in shape and the cage structure of these crystalline molecules was the active binding site of the analyte, tetracycline (TET).
View Article and Find Full Text PDFHeavy metals represent a considerable threat, and the current study deals with synthesizing a novel MOF nanocomposite by intercalating graphene oxide (GO) and linker UiO-66-NDC. It was shown that UiO-66-NDC/GO had enhanced the removal efficiency of Pb (II) ions at pH 6. The adsorption kinetics data followed the PSO (Type 2) representing chemisorption.
View Article and Find Full Text PDFChromium is detected in most ecosystems due to the increased anthropogenic activities in addition to that developed from natural pollution. Chromium contamination in the food chain results due to its persistent and non-degradable nature. The release of chromium in the ecosystem accretes and thereafter impacts different life forms, including humans, aquatic and terrestrial organisms.
View Article and Find Full Text PDFWith millions of tonnes of plastic pollution generated every year, small-sized plastic particles, including micro- and nanoplastics, end up in freshwater systems. Due to the very small size and very large specific surface area of nanoplastics, they are known to be persistent and toxic in our environment. These particles are also known to react with other water-borne contaminants and cause acute toxicity in organisms.
View Article and Find Full Text PDFHerein, for the adsorption and detection of As (III), multifunctional nanohybrid have been synthesized using a solvothermal approach. Structural and functional characterizations confirmed the impregnation of the ZnO over graphene oxide. Nanohybrid exhibits a remarkable q (maximum adsorption capacity) of 8.
View Article and Find Full Text PDFThe role of calcium release-activated calcium (CRAC) channels is well characterized and is of particular importance in T-cell function. CRAC channels are involved in the pathogenesis of several autoimmune diseases, making it an attractive therapeutic target for treating inflammatory diseases, like rheumatoid arthritis (RA). A systematic structure-activity relationship study with the goal of optimizing lipophilicity successfully yielded two lead compounds, and .
View Article and Find Full Text PDFMetal-based adsorbents are limited for hexavalent chromium [Cr(VI)] adsorption from aqueous solutions because of their low adsorption capacities and slow adsorption kinetics. In the present study, decorated zinc oxide (ZnO) nanoparticles (NPs) on graphene oxide (GO) nanoparticles were synthesized via the solvothermal process. The deposition of ZnO NPs on graphene oxide for the nanohybrid (ZnO-GO) improves Cr(VI) mobility in the nanocomposite or nanohybrid, thereby improving the Cr(VI) adsorption kinetics and removal capacity.
View Article and Find Full Text PDFThe exploitation of GLU988 and LYS903 residues in PARP1 as targets to design isoquinolinone (I & II) and naphthyridinone (III) analogues is described. Compounds of structure I have good biochemical and cellular potency but suffered from inferior PK. Constraining the linear propylene linker of structure I into a cyclopentene ring (II) offered improved PK parameters, while maintaining potency for PARP1.
View Article and Find Full Text PDFThe recent outbreak of CoVID-19 is declared as a global public health emergency of international concern by the World Health Organization (WHO). A fresh figure of 2268011 positive cases and 155185 death records (till April 18 2020) across the worldwide signify the severity of this viral infection. CoVID-19 infection is a pandemic, surface to surface communicable disease with a case fatality rate of 3.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
April 2015
Transition metal complexes containing tri-dentate NSN donor ligands i.e., 5-((1(aminomethyl)cyclohexyl)methyl)-1,3,4-thiadiazol-2-amine (AMTA) (2) and 5-(2-aminophenyl)-1,3,4-thiadiazol-2-amine (ATA) (4i-ii) have been synthesized.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
October 2014
Present work reviews that, the synthesis of (E)-N'-((7-hydroxy-4-methyl-2-oxo-2H-chromen-8-yl)methylene)benzohydrazide [L] ligand and their metal complexes. The colored complexes were prepared of type [M(2+)L]X2, where M(2+)=Mn, Co, Ni, Cu, Sr and Cd, L=(7-hydroxy-4-methyl-2-oxo-2H-chromen-8-yl)methylene)benzohydrazide, X=Cl(-). Ligand derived from the condensation of 8-formyl-7-hydroxy-4-methylcoumarin and benzohydrazide in the molar ratio 1:1 and in the molar ratio 1:2 for metal complexes have been prepared.
View Article and Find Full Text PDFBackground: The treatment of non union can be challenging with a variety of surgical options available to achieve bone consolidation. Robert Judet first described a method of osteo-periosteal decortication in 1963. He stated that by elevating cortical chips that remain attached to the periosteum and overlying soft tissues surrounding the site of non-union, combined with mechanical support, the bone consolidated.
View Article and Find Full Text PDF