Lensless Fourier transform multiplexed digital holography.

In this work, a new framework of lensless Fourier transform multiplexed digital holography (LFTMDH) is proposed, leveraging the double field of view (FoV) in a single-shot recording. The proof-of-concept system with double FoV is realized by adopting a spatially multiplexing technique by inserting a cube beam splitter in the object path. The cube beam splitter divides the object beam into two FoVs with different object information.

Prenatal arsenic exposure alters EZH2/H3K27me3 to induce RKIP/NF-kB/ERK1/2-mediated early-onset kidney disease in mouse offspring.

The rising incidences of chronic kidney disease (CKD) and renal failure are a major public health concern. Arsenic, a widespread water contaminant and environmental toxicant, is well-known to contribute to kidney disease in adults. However, its long-term effects on kidney health following early-life exposure remain poorly understood.

Investigating the Causes of Non-adherence to Recommended Lifestyle Modifications Among Indian Patients With Newly Diagnosed Type 2 Diabetes Mellitus or Hypertension.

Background and objective Lifestyle modification (related to diet and physical activity) is a key part of treatment for patients diagnosed with type 2 diabetes or hypertension. However, many patients are unable to follow the prescribed lifestyle modifications. This study aimed to investigate the causes of non-adherence in Indian adult patients with newly diagnosed type 2 diabetes mellitus (T2DM) or hypertension, who were advised lifestyle modifications along with pharmacotherapy.

Does outdoor air pollution cause poor semen quality? A systematic review and meta-analysis.

Introduction: It is hypothesized that air pollutants could be associated with semen parameters. This systematic review and meta-analysis of observational studies was conducted to reach a firm conclusion regarding the possible association between outdoor air pollution and semen parameters among the adult population.

Methods: PubMed, Scopus, and ISI Web of Science were systematically searched using the text keywords and MeSH terms, including "air pollution" and "semen parameters,".

Optimal satellite selection using quantum convolutional autoencoder for low-cost GNSS receiver applications.

The increasing reliance on global navigation satellite systems for diverse applications necessitates the development of efficient satellite selection methods to optimize positioning accuracy and system performance. In particular, low-cost global navigation satellite systems receivers face challenges in managing data from multiple visible satellites, often resulting in suboptimal performance due to high geometric dilution of precision values. Effective satellite selection is crucial for improving the accuracy and reliability of positioning solutions in these systems.

What imaging characteristics are suggestive of malignancy in patients with femoral neck fractures? A look at calcar impaction lesions.

Introduction: Femoral heads are often sent for histological analysis when malignancy is suspected following a neck of femur (NOF) fracture. Anecdotally, a commonly seen lytic appearance on plain radiographs prompts suspicion of malignancy but does not correlate with histology results.

Aim: To evaluate the radiographic patterns of NOF fractures deemed suspicious for malignancy, and correlate those patterns with their subsequent histology results.

Unique presentation of oral glial choristoma in a middle aged lady post teeth extraction with osteomyelitis; A case report.

Glial choristoma (GC) is a rare developmental malformation commonly occur in nasal cavity and infrequently present at other sites like palate, tongue, pharynx, lips, and submandibular region. It usually occurs in the children either as an incidental finding or mass lesion or in association with cleft palate. GC is diagnosed by the demonstration of glial tissue on histopathology.

Genome sequence of AM6, isolated from a Parkinson's disease patient.

Here, we report the genome sequence of AM6, isolated from a fecal sample obtained from a Parkinson's disease patient. The bacterial genome was sequenced using Illumina technology on a NextSeq 500 platform. The assembled genome of comprises 4,318,463 base pairs with a G + C content of 47.

CXCR4 Inhibition Enhances the Efficacy of CD19 Monoclonal Antibody-Mediated Extermination of B-Cell Lymphoma.

CD19 and CXCR4 are pivotal regulators of B-cell activation and migration, respectively. Specifically, CXCR4 signaling critically influences the dissemination of various malignant B cells through constitutive activation and aberrant expression. This study explores the interaction between CD19 and CXCR4 signaling in the context of B-cell lymphomas, particularly focusing on diffuse large B-cell lymphoma (DLBCL) and Waldenström Macroglobulinemia (WM).

The impact of interactive text communication on neonatal mortality in Kenya: a randomized controlled trial.

Text communication between newborns' caregivers and healthcare workers allows for real-time decisional guidance; however, its impact on neonatal health outcomes is unknown. Mobile WACh NEO (MWACh NEO) was a parallel, unblinded and individually randomized controlled trial at six health facilities across Kenya. Pregnant women at 28-36 weeks gestation were randomized (1:1) to the MWACh NEO intervention or standard of care.

Microstructural and statistical analysis on mechanical performance of novel flattened end nylon fibre reinforced concrete.

This study investigates the use of novel flattened-end nylon fibres (FENF) as reinforcement in concrete to improve its mechanical properties. The research addresses inadequate circumferential bonding between macro synthetic fibres and concrete matrix, which can lead to fibre slippage or failure. Through experiments involving 19 concrete mixes with varying fibre dosages (0.

On arrival continuous brachial plexus block provides superior analgesia with reduced persistent postsurgical pain in complex hand injuries: A randomized controlled trial.

Background: Patients with complex hand injuries experience extreme pain and frequently witness prolonged preoperative waiting period, which intensifies their agony, especially during wound dressing and debridement, further intensifying pain of acute trauma. Hence, there is a need to study utility of continuous peripheral nerve block in settings of acute trauma emergencies. We hypothesized that, as compared with intravenous systemic analgesics, continuous brachial plexus block would provide superior analgesia in these patients.

An integrated proteo-transcriptomics approach reveals novel drug targets against multidrug resistant .

Infections due to multidrug-resistant (MDR) are associated with severe morbidity and mortality, worldwide. Microbial drug resistance is a complex phenomenon which is conditioned by an interplay of several genomic, transcriptomic and proteomic factors. Here, we have conducted an integrated transcriptomics and proteomics analysis of MDR to identify genes which are differentially expressed at both mRNA and protein levels.

Crystal structure, Hirshfeld surface analysis, DFT and mol-ecular docking studies of 4'-(benz-yloxy)-[1,1'-biphen-yl]-3-carb-oxy-lic acid.

In the title compound, CHO, intra-molecular C- H⋯O hydrogen bonds are observed. The dihedral angles between the aromatic benzoic acid ring and the two adjacent aromatic rings are 26.09 (4) and 69.

Comparative efficacy of advanced and traditional wound dressings in post-operative orthopaedic care for hip and knee surgeries: A randomized controlled trial.

Background: This randomized controlled study aimed to evaluate the efficacy of three advanced dressings (Aquacel Ag®, Opsite® Post-Op, and Mepilex Border Post-Op®) versus traditional dressings in post-operative care for patients undergoing orthopaedic hip or knee surgeries.

Methods: Conducted between August and December 2022 at a tertiary care orthopaedic centre, 314 patients were randomized into four groups. Group A received Aquacel Ag®, Group B received Opsite® Post-Op, Group C received Mepilex Border Post-Op®, and Group D received traditional dressings.

DFT investigation of 5-fluorouracil tautomerism and non-covalent interactions with PLGA nanoparticles for enhanced drug delivery and sensing.

This study investigates the non-covalent interactions between both the free and tautomeric forms of 5-fluorouracil (5-FU) and poly(lactic-co-glycolic acid) (PLGA) nanoparticles through density functional dispersion correction (DFT-D) at the B3LYP-D level in a dichloromethane (DCM) and water environments. Our results indicate that the non-covalent interactions formed between the carbonyl and amide groups of the free form of 5-FU and the carboxyl group of PLGA facilitate a rapid initial release of the drug, aligning with experimental findings. The calculated binding energies for 5-FU in its keto-enol (-0.

Tandem Synthesis of Polysubstituted Pyrroles via Cu(I)-Catalyzed Cyclization of Ketene -Acetals with β-Ketodinitriles.

A new approach to multifunctionalized pyrroles has been explored by the tandem cyclization of α-oxoketene-,-acetals with β-ketodinitriles using Cu(MeCN)BF and AgCO in toluene under reflux conditions. The reaction involves C-C/C-N bond creation, and is assumed to proceed via enamine formation, intramolecular cyclization, and rearrangement. The potential of the methodology has also been demonstrated for a gram-scale reaction as well as for some useful organic transformations.

Giant Polyoxometalate {W72Fe30} into Pure Inorganic Gel and Xerogel: Rheology and Proton Conduction.

Polyoxometalate (POM) gel is well-known but mostly with organic molecules.  Pure inorganic POM gel, i.e.

Nanoscale Metal-Organic Frameworks: An Emerging Versatile Tool for Next-Generation Photodynamic Therapy.

Photodynamic therapy has emerged as a potent strategy for treatment of cancer due to its non-invasiveness, minimal toxicity, high spatial selectivity, and potential for combination therapies. However, self-aggregation of photosensitizers, tumour hypoxia and low penetration depth of excitation photons remain prominent challenges towards its clinical application. Nanoscale metal-organic frameworks have emerged as one of the most promising materials due to their tunable composition which allows the adjustment of optical and chemical properties by changing the metal ions or organic linkers.

Lipoid Proteinosis-An Unusual Cause of Hoarseness of Voice in a Child: Case Report.

Lipoid proteinosis is a rare hereditary multisystemic familial disorder characterised by intracellular deposition of hyaline material (Rao and Koppada in Indian J Dermatol Venereol Leprol, 2015; Shah and Shah in J Oral Maxillofac Pathol 26:236-241, 2022). The hallmark findings are pox like scarred skin lesion, hoarseness of voice and selective brain parenchymal calcification (Rao and Koppada in Indian J Dermatol Venereol Leprol, 2015). We present a case of biopsy proven lipoid proteinosis with typical radiological findings.

Intrinsic retinoic acid synthesis is required for oligodendrocyte progenitor expansion during CNS remyelination.

Myelin regeneration (remyelination) in the CNS depends on the recruitment, proliferation and differentiation of oligodendrocyte precursor cells (OPCs) at demyelinated lesions. However, despite the presence of OPCs, very few oligodendrocytes and myelin are regenerated in chronic multiple sclerosis (MS) lesions for reasons that remain poorly understood. Here, using a spontaneous remyelination model in mice, we found that retinaldehyde dehydrogenase 2 (Raldh2), a rate-limiting enzyme for retinoic acid (RA) synthesis, is upregulated in OPCs and in a subpopulation of microglia/macrophages during remyelination.

Clinical and demographic profiling of snakebite envenomation in a tertiary care centre in northern India.

Background: Snake bites are a major cause of emergency visits in tropical countries like India, with actual mortality and morbidity likely higher due to underreporting. The aim of the study was to analyze the clinical and demographic profiles of snake bites at the Department of Emergency Medicine, AIIMS Rishikesh, over two years (July 2021 to July 2023).

Methods: Patients aged over 18 with witnessed or suspected snake bites were included.

Index-Based selection of Chickpea (Cicer arietinum L.) genotypes for enhanced drought tolerance.

Chickpea, a protein-rich legume grown primarily in tropical and subtropical regions, faces significant challenges due to drought stress. A field study was conducted over two years (2020-21 and 2021-22) aimed to identify chickpea genotypes that are tolerant to drought. The study involved 25 chickpea genotypes subjected to irrigated (control) and water stress (drought) conditions and the experiment was arranged in a split-plot design.

Bowen's Disease of the Labia Majora: A Rare Case.

Bowen's disease is a non-melanocytic in situ squamous cell carcinoma of the epidermis. Having a multifactorial etiology, its incidence has been found to be the highest in Caucasians. It commonly occurs as a solitary lesion in the elderly on the photoexposed areas of the skin, mainly in the head and neck region.