CG17192 is a Phospholipase That Regulates Signaling Lipids in the Gut upon Infection.

The chemoproteomics technique, activity-based protein profiling (ABPP), has proven to be an invaluable tool in assigning functions to enzymes. The serine hydrolase (SH) enzyme superfamily, in particular, has served as an excellent example in displaying the versatility of various ABPP platforms and has resulted in a comprehensive cataloging of the biochemical activities associated within this superfamily. Besides SHs, in mammals, several other enzyme classes have been thoroughly investigated using ABPP platforms.

Impact of Triclosan on Bacterial Biodiversity and Sediment Enzymes - A Microcosm Study.

Triclosan (TCS), a widely used antimicrobial biocide, has raised serious concern among the scientific community in recent years owing to its ubiquitous presence around the globe and toxicity to aquatic organisms. The current study investigated the alterations in bacterial diversity, nutrients, and sediment enzyme activity in TCS-exposed sediment. TCS concentrations of 3 mg/L (T1) and 6 mg/L (T2) were applied in a microcosm setup for 28 days to sediment collected from Versova Creek, Mumbai.

Gut microbiome as biomarker for triclosan toxicity in Labeo rohita: bioconcentration, immunotoxicity and metagenomic profiling.

Triclosan (TCS) is a lipophilic, broad spectrum antimicrobial agent commonly used in personal care products with a projected continuous escalation in aquatic environments in the post COVID 19 era. There is rich documentation in the literature on the alteration of physiological responses in fish due to TCS exposure; however, studies on gut associated bacteria of fish are still scarce. This is the first attempt to determine changes in bacterial community structure due to exposure of TCS on Labeo rohita, a commercially essential freshwater species, using 16S V3-V4 region ribosomal RNA (rRNA) next-generation sequencing (NGS).

Ecotoxicological effects of triclosan on Lemna minor: bioconcentration, growth inhibition and oxidative stress.

Triclosan (TCS), an emerging pollutant, is a notable contributor to adverse impacts on aquatic organisms due to its widespread use during COVID-19 and hydrophobic properties. There is extensive documented literature on TCS toxicity in commercially important fish species; however, studies on aquatic plants remain limited. In this prelude, the present study aims to evaluate the effect of TCS on Lemna minor, a commercially important aquatic plant species for 7 days.

Knockdown resistance mutations in Phlebotomus argentipes sand flies in Bihar, India.

Background: Vector control based on indoor residual spraying (IRS) is one of the main components of the visceral leishmaniasis (VL) elimination programme in India. Dichlorodiphenyltrichloroethane (DDT) was used for IRS until 2015 and was later replaced by the synthetic pyrethroid alpha-cypermethrin. Both classes of insecticides share the same target site, the voltage-gated sodium channel (Vgsc).

Ecotoxicological risk assessment of triclosan, an emerging pollutant in a riverine and estuarine ecosystems: A comparative study.

Triclosan (TCS), an antibacterial biocide, pervades water and sediment matrices globally, posing a threat to aquatic life. In densely populated cities like Mumbai, rivers and coastal bodies demand baseline TCS data for ecotoxicological assessment due to the excessive use of personal care products comprising TCS. This pioneering study compares spatiotemporal TCS variations and risks in freshwater and marine ecosystems employing multivariate analysis of physicochemical parameters.

Doping Engineering in Electrode Material for Boosting the Performance of Sodium Ion Batteries.

In recent years, sodium ion batteries (SIBs) emerged as promising alternative candidates for lithium ion batteries (LIBs) due to the high abundance and low cost of sodium resources. However, their commercialization has been hindered by inherent limitations, such as low energy density and poor cycling stability. To address these issues, doping methodology is one of the most promising approaches to boosting the structural and electrochemical properties of SIB electrodes.

SWI/SNF complex-mediated chromatin remodeling in promotes immune evasion.

Immune evasion is critical for fungal virulence. However, how the human opportunistic pathogen () accomplishes this is unknown. Here, we present the first genome-wide nucleosome map of the macrophage-internalized consisting of ∼12,000 dynamic and 70,000 total nucleosomes.

Overexpression of OsTIP1;2 confers arsenite tolerance in rice and reduces root-to-shoot translocation of arsenic.

Tonoplast Intrinsic Proteins (TIPs) are vital in transporting water and solutes across vacuolar membrane. The role of TIPs in the arsenic stress response is largely undefined. Rice shows sensitivity to the arsenite [As[III]] stress and its accumulation at high concentrations in grains poses severe health hazards.

Evaluation of acute toxicity of an emerging contaminant Oxybenzone on an ecologically important aquatic macrophyte Lemna minor.

Oxybenzone is an ultraviolet filter frequently used in Personal Care Products, plastics, furniture, etc. and is listed as an Emerging Contaminant. This report studied the acute toxicity of Oxybenzone to Lemna minor after exposure to graded concentrations of Oxybenzone for 7 days.

Performance prediction of a circularly polarized graphene-dielectric resonator-based antenna for THz frequency application using machine learning algorithms.

In this article, a graphene-dielectric resonator-based antenna is designed in the THz frequency regime. Circular polarization is achieved by feeding the cylindrical-shaped ceramic using a perturbed square-shaped aperture. Graphene loading over the alumina ceramic provides the frequency reconfigurable feature.

Plasma membrane intrinsic protein OsPIP2;6 is involved in root-to-shoot arsenic translocation in rice (Oryza sativa L.).

This study demonstrates the crucial role of OsPIP2;6 for translocation of arsenic from roots to shoots, which can decrease arsenic accumulation in rice for improved food safety. Arsenic (As) contamination in food and water, primarily through rice consumption, poses a significant health risk due to its natural tendency to accumulate inorganic arsenic (iAs). Understanding As transport mechanisms is vital for producing As-free rice.

Rice tonoplast intrinsic protein member OsTIP1;2 confers tolerance to arsenite stress.

The International Agency for Research on Cancer categorizes arsenic (As) as a group I carcinogen. Arsenic exposure significantly reduces growth, development, metabolism, and crop yield. Tonoplast intrinsic proteins (TIPs) belong to the major intrinsic protein (MIP) superfamily and transport various substrates, including metals/metalloids.

Comparison of collection methods for Phlebotomus argentipes sand flies to use in a molecular xenomonitoring system for the surveillance of visceral leishmaniasis.

Background: The kala-azar elimination programme has resulted in a significant reduction in visceral leishmaniasis (VL) cases across the Indian Subcontinent. To detect any resurgence of transmission, a sensitive cost-effective surveillance system is required. Molecular xenomonitoring (MX), detection of pathogen DNA/RNA in vectors, provides a proxy of human infection in the lymphatic filariasis elimination programme.

A π-conjugated covalent organic framework enables interlocked nickel/photoredox catalysis for light-harvesting cross-coupling reactions.

Covalent organic frameworks (COFs) are an outstanding platform for heterogeneous photocatalysis. Herein, we synthesized a pyrene-based two-dimensional C[double bond, length as m-dash]C linked π-conjugated COF Knoevenagel condensation and anchored Ni(ii)-centers through bipyridine moieties. Instead of traditional dual metallaphotoredox catalysis, the mono-metal decorated Ni@Bpy-spc-COF interlocked the catalysis mediated by light and the transition metal.

Classifying histopathological images of oral squamous cell carcinoma using deep transfer learning.

Oral cancer is a prevalent malignancy that affects the oral cavity in the region of head and neck. The study of oral malignant lesions is an essential step for the clinicians to provide a better treatment plan at an early stage for oral cancer. Deep learning based computer-aided diagnostic system has achieved success in many applications and can provide an accurate and timely diagnosis of oral malignant lesions.

Novel Bioactive Magnesium-Hopeite composite by friction stir processing for orthopedic implant applications.

Magnesium (Mg) shows excellent potential for orthopedic implant applications owing to its equivalent mechanical properties compared to cortical bone and its biocompatibility. However, the rapid degradation rate of magnesium and its alloys in the physiological environment results in losing their mechanical integrity before complete bone healing. In light of this, friction stir processing (FSP), a solid-state process, is used to fabricate Hopeite (Zn(PO).

Cloning, homology modelling and expression analysis of Oryza sativa WNK gene family.

With No Lysine kinases (WNKs) represents a gene family that encodes Ser/Thr kinases, with anomalous disposition of catalytic lysine residue in subdomain I. In plants, WNKs had been linked to circadian rhythm, photoperiodic response and abiotic stress tolerance with mechanism yet undeciphered. In the present study, full-length CDS sequences of rice WNKs (OsWNK1 to 8) were cloned from indica cultivar IR64.

Anthropogenic risk assessment of riverine habitat using geospatial modelling tools for conservation and restoration planning: a case study from a tropical river Pranhita, India.

The riverine ecosystem provides multiple benefits to human community and contributes to the sustainable development of the ecoregion. The growing dependency on these ecosystems has largely contributed to aggravating the ecological risks, habitat degradation, and loss of ecosystem services. The present study evaluates the ecological risk emanating from nine anthropogenic stressors including river use, hydro-morphology, catchment pollution, and biological stressor on river Pranhita in Godavari Basin of Peninsular India using InVEST (Integrated Valuation of Ecosystem Services and Tradeoffs) Habitat Risk Assessment model.

Cloning and functional characterization of arsenite oxidase (aoxB) gene associated with arsenic transformation in Pseudomonas sp. strain AK9.

Arsenic transforming bacterial strains belong to genus Pseudomonas sp.AK9 (KY569424), were isolated from the middle Gangetic plains of Bihar, India. The Pseudomonas sp.

Insights into established and emerging roles of SR protein family in plants and animals.

Splicing of pre-mRNA is an essential part of eukaryotic gene expression. Serine-/arginine-rich (SR) proteins are highly conserved RNA-binding proteins present in all metazoans and plants. SR proteins are involved in constitutive and alternative splicing, thereby regulating the transcriptome and proteome diversity in the organism.

Correlation with the Microstructure and Synergistic Physiochemical Etching Resistance of Nanocomposites under Fluorine-Containing Plasma Conditions.

In the semiconductor fabrication industry, high-power plasma is indispensable to obtain a high aspect ratio of chips. For applications to ceramic components including the dielectric window and ring in the semiconductor etching chamber, the YO ceramics have attracted interest recently based on excellent erosion resistance. When a high bias voltage is applied in a plasma environment containing fluorine gas, both chemical etching and ion bombardment act simultaneously on the ceramic components.

An invasive weed-associated bacteria confers enhanced heat stress tolerance in wheat.

Global temperatures are expected to increase due to climate change, and heat stress is one of the major limiting factors affecting future agriculture. To identify plant-associated microorganisms which can promote heat stress tolerance in wheat, we have screened several bacteria isolated from etiolated seedlings of the invasive noxious weed . One isolate designated as Ph-04 was found to confer enhanced heat stress tolerance in wheat.