Publications by authors named "Kumar D"

To evaluate the quality of life in the post maxillectomy patients due to Coronavirus disease 2019 (COVID-19) associated Mucormycosis (CAM) following rehabilitation with obturators. The study also described the management and treatment outcomes of CAM patients. The study included 80 confirmed patients of CAM.

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  • Alzheimer's disease (AD) is a major cause of dementia with no effective therapies, leading to high financial and personal costs due to its devastating impact on health.
  • Key pathological features of AD include the accumulation of amyloid β peptides and hyperphosphorylated Tau protein, which result in neuronal death, but a complete understanding of the underlying molecular mechanisms remains incomplete.
  • Recent studies emphasize the role of noncoding RNAs (ncRNAs), particularly microRNAs (miRNAs), in regulating gene expression related to AD, presenting them as potential biomarkers and therapeutic targets to help prevent the disease's progression.
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Patients with locally advanced breast cancer post-mastectomy complain of shoulder pain and restricted shoulder movement. The role of suprascapular nerve block (SSNB) in such patients needs to be explained as it may help in improving their quality of life along with pain relief. This study aims to evaluate the effect of ultrasound-guided suprascapular nerve block (SSNB) in improving shoulder motion and pain following surgery and compare its effect with exercise group.

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Unlabelled: Electroencephalography-based (EEG) microstate analysis is a promising and widely studied method in which spontaneous cerebral activity is segmented into sub second level quasi-stable states and analyzed. Currently it is being widely explored due to increasing evidence of the association of microstates with cognitive functioning and large-scale brain networks identified by functional magnetic resonance imaging (fMRI). In our study using the four archetypal microstates (A, B, C and D), we investigated the changes in resting state EEG microstate dynamics in persons with temporal lobe epilepsy (TLE) and idiopathic generalized epilepsy (IGE) compared to healthy controls (HC).

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Introduction: Each Indian state can select one of the two implementation models under India's National Adolescent Health Strategy, i.e., Rashtriya Kishor Swasthya Karyakram, either direct implementation through the existing State Health Department and systems, or the Non-Governmental Organisation (NGOs) implementation model, which involves partnering with one or more field-level NGOs to provide the services and personnel.

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Reliability is a crucial factor to consider for multi-level inverters (MLIs) used in industrial applications. With the increasing number of power semiconductor devices, the potential for defects to significantly degrade the overall system is heightened. A highly effective fault-detection technique is required to minimize the impact of faults.

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Histone deacetylase 6 (HDAC6) inhibition is associated with an increased pro-inflammatory tumor microenvironment and antitumoral immune responses. Here, we show that the HDAC6 inhibitor AVS100 (SS208) had an antitumoral effect in SM1 melanoma and CT26 colon cancer models and increased the efficacy of anti-programmed cell death protein 1 treatment, leading to complete remission in melanoma and increased response in colon cancer. AVS100 treatment increased pro-inflammatory tumor-infiltrating macrophages and CD8 effector T cells with an inflammatory and T cell effector gene signature.

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  • Tuberculosis is common in India, while Histoplasmosis is less reported; co-infection is rare but challenging to diagnose due to symptom overlap.
  • A 62-year-old man was diagnosed with both conditions, initially treated with appropriate medications, but experienced complications due to drug interactions.
  • Follow-up treatment adjustments led to significant improvement, highlighting the need for careful monitoring and awareness of potential drug interactions in similar cases.
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Background: Diabetes is a chronic medical condition with severe complications, mainly caused by unhealthy lifestyles in genetically susceptible individuals. There has been a growing interest in the role of mobile health technologies in achieving better self-efficacy in managing diabetes. This study attempts to assess the impact of a web-based model on improving the diabetes status among Type 2 diabetic patients attending a tertiary care hospital in southern India.

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The utilization of plant-derived chemicals with anti-diabetic properties is widely promoted for its advantageous tactics in managing diabetes, as they are cost-effective and have minimal or no adverse effects. Therefore, this work investigates the medicinal plant L. leaves by extraction and bio-guided fractionation.

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Background: We evaluated whether preoperative functional status influenced surgical outcomes for patients with intramedullary spinal cord tumors (IMSCT).

Methods: We analyzed whether lower preoperative McCormick scores impacted primary outcomes for 78 consecutive patients with IMSCT of World Health Organization (WHO) grades I and II undergoing tumor resection between 2010 and 2018.

Results: Patients averaged 33.

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  • * A study surveyed 1,016 adults in rural Jammu, finding a 20.67% prevalence of psychiatric disorders, primarily alcohol dependence (12.30%) and generalized anxiety disorder (3.14%).
  • * Key factors linked to higher prevalence included older age, marital status, lower education levels, and socioeconomic status, highlighting the need for targeted mental health interventions in these communities.
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This article presents a flexible four-element antenna for X-band applications. The proposed antenna covers the spectrum ranging from 10.6 to 11.

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The field of high energy density materials faces a long-standing challenge to achieve an optimum balance between energy and stability. While energetic salt formation via a combination of oxygen- and nitrogen-rich anions (providing energy) with nitrogen-containing cations (providing stability) has been a proven approach for improving physical stability, constraints such as lowering density and energetic performance remain unresolved. This can be addressed by utilizing oxygen-containing cations for salt formation.

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DNA methyltransferase 3A (DNMT3A) plays a critical role in establishing and maintaining DNA methylation patterns in vertebrates. Here we structurally and biochemically explore the interaction of DNMT3A1 with diverse modified nucleosomes indicative of different chromatin environments. A cryo-EM structure of the full-length DNMT3A1-DNMT3L complex with a H2AK119ub nucleosome reveals that the DNMT3A1 ubiquitin-dependent recruitment (UDR) motif interacts specifically with H2AK119ub and makes extensive contacts with the core nucleosome histone surface.

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  • The study emphasizes the need to utilize industrial byproducts like coal ash in civil engineering to mitigate environmental pollution and waste.
  • It investigates the properties of controlled low-strength material (CLSM) made from coal ash, focusing on flowability and unconfined compressive strength (UCS) after 28 days.
  • Four machine learning models were tested to predict UCS, with the multivariate adaptive regression splines (MARS) model showing the best performance, providing better accuracy than traditional methods and highlighting key factors influencing CLSM effectiveness.
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Background: Fungal infective endocarditis (IE) is a rare, yet increasingly recognised condition associated with substantial mortality rates. and are among the notable causative agents, presenting diverse clinical manifestations and complexities in diagnosis and management.

Objectives: This study was undertaken to examine the clinical profiles, diagnostic challenges, treatment modalities, and outcomes of four compelling cases involving and endocarditis.

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  • The study identified 46 metabolites in the milk of Ladakhi cows using advanced NMR spectroscopy, highlighting differences between colostrum, transition milk, and mature milk.
  • Multivariate analysis showed that specific metabolites like UDP-galactose and creatine phosphate could effectively differentiate the stages of milk, indicating their importance in cell growth and defense.
  • The findings underscore how certain metabolites in colostrum may support the growth and development of calves in the challenging high-altitude environment of Leh-Ladakh.
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Background & objectives Overcoming the challenge of early diagnosis of prostate cancer (PCa) by exploring molecular biomarkers is urgently needed. With this objective, this study was designed to explore the biomarker and therapeutic potential of miRNA (miR)-363-3p in PCa pathogenesis. Methods Total participants (n=188) were enrolled, and blood and tissue samples were collected from individuals categorized into the control group (n=55), benign prostate hyperplasia (BPH) group (n=60), PCa group (n=48), and castration-resistant PCa (CRPC) group (n=25).

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Introduction: Cardiomyopathy is a complex condition influenced by multiple genes and environmental factors. It has been suspected that cardiomyopathy is affected by the ACE gene's I/D polymorphism. Our study aimed to evaluate the association between this polymorphism and cardiomyopathy risk in the Jammu population of North India, alongside a meta-analysis to determine the specific risks associated with different types of cardiomyopathy.

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Consumer-grade optical heart rate (HR) sensors emerged as promising tools to monitor volume and intensity of physical activity (PA). However, no validation study of optical HR sensors included recent comprehensive validation recommendations, required for facilitating usage for medical purposes. Validity of HR data measured with four consumer-grade optical sensors, the wrist-worn Garmin Venu 2S and Polar Vantage M2, and the upper arm-worn Polar Verity Sense and Scosche Rhythm24 were assessed in 32 participants over 24 h including various laboratory-based and free-living activities.

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Background This study aimed to evaluate tumor-infiltrating lymphocytes (TILs) as predictors of response to neoadjuvant chemotherapy (NACT) in patients with locally advanced breast cancer (LABC). Methods Overall, 35 patients with LABC were included in the study. Information on demographic profile, medical history, and signs and symptoms was collected for each patient, and a complete clinical evaluation was conducted, which involved physical examination, imaging studies (mammogram/ultrasound imaging), biopsy of each patient, and a metastatic workup.

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Unlabelled: Disorders related to defaecation are widely common in the population and are often overlooked. Patients may present with a wide variety of symptoms such as constipation, faecal incontinence, painful defaecation, incomplete defaecation, hard stools, rectal bleeding, and mass per rectum. Complete clinical examination with radiological imaging, using dynamic MR Defaecography, can help in assessing, grading, and managing posterior compartment pelvic floor disorders and complex dysfunctions.

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This study investigates the use of pH-responsive nanogels for delivering Bosutinib (BOSU) in colon cancer treatment. Nanogels were formulated using three polymers: hyaluronic acid (HA), carboxymethyl dextran (CMD), and gelatin methacryloyl (GelMA). These nanogels achieved high drug entrapment efficiencies (80-90%) through polymer mixing with BOSU, followed by EDC/NHS cross-linking and sonication.

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  • Rhynchosia minima plants from the Indian Institute of Pulses Research exhibited yellow mosaic symptoms, suspected to be caused by begomoviruses, primarily identified as mungbean yellow mosaic India virus in four samples tested via PCR.
  • One plant sample (Rhm2) tested negative for this virus but later analyses revealed it contained two DNA molecules associated with the rhynchosia yellow mosaic virus (RhYMV), which were closely related to known isolates with significant nucleotide similarities.
  • Phylogenetic analysis indicated RhYMV-IN-Knp's lineage and highlighted two recombination events, suggesting a risk of infection to cultivated legumes, emphasizing the need for ongoing monitoring, particularly in pigeonpea
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