Optimizing conditions for microwave-assisted solvent extraction of polar compounds from Carissa carandas.

The present investigation aimed to optimize the solvent combination and microwave-assisted extraction (MAE) conditions for extracting polar phyto-components from Carissa carandas, which is an underutilized fruit rich in various bioactive compounds. Initially, an augmented simplex centroid design was used to investigate the influence of four polar solvents (methanol, ethanol, acetone, and water) on the extraction of phyto-compounds, including total sugars, reducing sugars, total polyphenols, flavonoids, and antioxidant activity of the extract. The desirability function determined that a solvent combination of ethanol-water (49:51, v/v) was the most effective for extracting polar components from C.

Lead-Free All Inorganic Rubidium Copper Halide RbCuX (X = Cl, Br) for UVC Photodetector with Fast Response.

Recently, lead halide perovskites have shown great potential in the photodetection field. Unfortunately, the existence of toxic lead elements restricts their practical application. Herein, high-quality 1D lead-free crystals RbCuX (X = Cl, Br) are successfully synthesized in an acidic medium.

An improved DNA extraction method in okra for rapid PCR detection of Okra enation leaf curl virus from diverse Indian regions.

The extraction of DNA from okra (Abelmoschus esculentus) is challenging due to its high mucilage and polysaccharide content, which can hinder both the yield and quality of DNA. In this study, an improved DNA isolation method is described incorporating a key modification being the use of solution I (1 M NaCl and 2% Sarcosyl) as a pre-treatment before applying the CTAB buffer, resulting in high-purity genomic DNA in just 1 h and 45 min., making it suitable for handling large sample sizes due to its rapid processing capabilities.

Shape-controlled, water-assisted synthesis of 2D luminescent CsPbBr perovskite microcrystals for highly responsive UV detectors.

Cesium-lead-halide (Cs-Pb-Br) perovskites have been a point of interest for researchers since their discovery for their extraordinary optical and electronic properties. Unlike other members of the Cs-Pb-Br family, CsPbBr is less explored. Herein, we synthesized 2D CsPbBr in an aqueous medium under ambient conditions.

Ancillary Ligand-Promoted Charge Transfer in Bis-indole Pyridine Ligand-Based Nickel Complexes.

There is growing demand for the utilization of first-row transition metal complexes in light-driven processes instead of their conventional noble metal counterparts due to the greater sustainability of first-row transition metal complexes. However, their major drawback is the ultrafast lifetime of the electronic excited states of these first-row transition metal complexes, particularly those of d square-planar systems such as Ni(II) complexes, wherein low-lying metal-centered (MC) states provide the deactivation pathway. To increase the excited-state lifetime and broaden their applications, it is important to develop sterically bulky, strong field ligands with low-lying π* orbitals and a highly σ-donating nature to augment the energy of MC states.

BCCHI-HCNN: Breast Cancer Classification from Histopathological Images Using Hybrid Deep CNN Models.

Breast cancer is the most common cancer in women globally, imposing a significant burden on global public health due to high death rates. Data from the World Health Organization show an alarming annual incidence of nearly 2.3 million new cases, drawing the attention of patients, healthcare professionals, and governments alike.

Pemetrexed-loaded supramolecular acetal-functionalized pH-responsive nanocarriers selectively induce apoptosis through biotin receptors to enhance antitumor efficacy.

A novel pH-responsive crystalsomes has been developed using acetal-functionalized pillar[5]arenes (AP[5]) and methyl viologen (MV) through host-guest interactions. The successful synthesis of AP[5] was confirmed via H-NMR spectroscopy, while the formation of the host-guest complex between AP[5] and MV was also verified using ¹H-NMR. The supramolecular assemblies formed at a 1:1 molar ratio of AP[5] to MV exhibited remarkable colloidal stability, a negative surface charge, and a high association constant.

Prevalence and Patterns of Oral Mucosal Lesions Among Geriatric Patients in India: A Retrospective Study.

Introduction: Geriatric dentistry plays a pivotal role in addressing the oral health needs of the elderly population, who are prone to various age-related disorders affecting the oral mucosa. This study aims to investigate the prevalence of oral mucosal lesions among geriatric patients in India, considering factors, such as age, gender, and systemic diseases.

Methodology: A hospital-based retrospective study was conducted, analyzing medical and clinical examination records of 354 geriatric patients attending a dental college/hospital between 2022 and 2023.

Local and global dynamics of a prey-predator system with fear, Allee effect, and variable attack rate.

Fear prompts prey to adopt risk-averse behaviors, such as reduced foraging activity, increased vigilance, and avoidance of areas with high predator presence, which affects its reproduction. In a real scenario, a population requires a minimum density to avoid extinction, known as an Allee threshold. In light of these biological factors, we propose a predator-prey model with (i) a fear effect in a prey population, (ii) an Allee effect in a predator population, and (iii) a non-constant attack rate that modifies the functional response.

A cub and sushi domain-containing protein with esterase-like activity confers insecticide resistance in the Indian malaria vector Anopheles stephensi.

Chemical insecticides (organophosphates and pyrethroids) in the form of IRS (Indoor Residual Sprays) and LLINs (Long Lasting Insecticidal Nets) are the cornerstone for vector control, globally. However, their incessant use has resulted in widespread development of resistance in mosquito vectors, warranting continuous monitoring and investigation of the underlying mechanisms of resistance. Here, we identified a previously uncharacterized- Cub and Sushi Domain containing Insecticide Resistance (CSDIR) protein and generated evidence for its role in mediating insecticide resistance in the Anopheles stephensi.

Current strategic arsenal and advances in nose to brain nanotheranostics for therapeutic intervention of glioblastoma multiforme.

The fight against Glioblastoma multiforme (GBM) is ongoing and the long-term outlook for GBM remains challenging due to low prognosis but every breakthrough brings us closer to improving patient outcomes. Significant hurdles in GBM are heterogeneity, fortified tumor location, and blood-brain barrier (BBB), hindering adequate drug concentrations within functioning brain regions, thus leading to low survival rates. The nasal passageway has become an appealing location to commence the course of cancer therapy.

Assessment of the Mechanical Properties of Different Suture Materials for Oral Surgery: An In Vitro Tensile Strength Study.

Background: Sutures are essential components of wound closure in oral surgery, and the mechanical properties of suture materials play a crucial role in determining surgical outcomes. Understanding the tensile strengths of various suture materials is vital for selecting the most appropriate material for specific clinical applications.

Objective: This study aimed to assess the tensile strength of suture materials commonly used in oral surgery through an in vitro tensile strength study.

A Study of Quality of Life of Elderly Live Kidney Donors-An Interview-Based Prospective Follow-Up Study.

Quality of life (QoL) is a vital aspect of postdonation amongst donors, especially elderly donors. There is a limited study from India assessing the QoL amongst young live donors (YLD), and no study has been done on the elderly sub-group. This study was undertaken to determine the donors' sociodemographic and essential clinical characteristics, as well as to study the QoL of the live kidney donors and compare the QoL of elderly and young donors.

Anti-inflammatory, antiosteoporotic, and bone protective effect of hydroxysafflor yellow A against glucocorticoid-induced osteoporosis in rats.

Osteoporosis is a common condition worldwide, affecting millions of people. Women are more commonly affected than men, and the risk increases with age. Inflammatory reaction plays a crucial role in the expansion of osteoporosis.

Comparative assessment of domestic wastewater treatment via Vermifiltration through various filter bed material.

Vermifilter (VF) is considered sustainable for rural areas; however, filter media is the most important but has been explored less. This study evaluated the performance of vermifilters in treating domestic wastewater (DWW) using various filter media, including areca nutshell (AS), rice straw (RS), dry leaves (DL), and chicken eggshells (ES). We compared the results with four different reactors: R1 (AS), R2 (RS), R3 (DL), and R4 (ES).

ELONGATED HYPOCOTYL 5 (HY5) and POPEYE (PYE) regulate intercellular iron transport in plants.

Plants maintain iron (Fe) homeostasis under varying environmental conditions by balancing processes such as Fe uptake, transport and storage. In Arabidopsis, POPEYE (PYE), a basic helix-loop-helix transcription factor (TF), has been shown to play a crucial role in regulating this balance. In recent years, the mechanisms regulating Fe uptake have been well established but the upstream transcriptional regulators of Fe transport and storage are still poorly understood.

A high-performance flexible humidity sensor based on a TiO-MWCNT nanocomposite for human healthcare applications.

The present work shows the improved humidity sensing characteristics of TiO nanoparticles in the form of a nanocomposite with multiwalled carbon nanotubes (MWCNTs) prepared by a hydration-dehydration method. The structural and morphological characterizations of TiO-MWCNTs confirm the nanocomposite formation without any other impurities and with an improved surface area. The pure TiO and nanocomposite films are deposited on IDE coated flexible poly-ethylene terephthalate (PET) substrates by a drop casting method.

Body Mass Index a Forecast of Sputum Culture Conversion Among Drug-Resistant Tuberculosis Patients.

Background Drug-resistant tuberculosis is a major health issue around the world. The time it takes to find a sputum-positive patient is a major risk factor for the spread of tuberculosis, and many things can indicate a longer time to culture conversion. Also, there is strong proof that poor nutrition is linked to infectious diseases.

, and Evaluation of the Antihyperglycaemic, Antioxidant and Cytotoxic Properties of L. Leaf Extract.

Research Background: L. is traditionally used for the treatment of diabetes mellitus. Since the scientific evidence and mechanism of action have not yet been extensively investigated, this study aims to evaluate the antidiabetic and cytotoxic effects together with the optimisation and development of a scale-up process design for higher yields of bioactive phytocompounds from

Experimental Approach: The study was conducted to predict the binding affinity of phytocompounds of for α-amylase and α-glucosidase enzymes involved in the pathophysiology of diabetes with pharmacokinetic assessment.

Postharvest quality and ripening behaviour of un-explored genotypes of Himalayan plain mango diversity.

India is renowned for its mango diversity, with more than 1000 genotypes reported. However, the Himalayan plains bear some elite genotypes which supposed to bear high postharvest value, the systemic postharvest study of which is yet to be attempted. The aim of present study is to evaluate the postharvest quality and ripening behviour of these important genotypes.

Phytocannabinoid profile and potency of cannabis resin (hashish) of northwest Himalayas of India.

Cannabis is one of the most consumed illicit drugs and the potency of cannabis products is of note due to health-related concerns. Hand-rubbed hashish is the ancient technique of extracting psychoactive resin from cannabis plants and is practiced in the Indian Himalayas. This study establishes the cannabinoid profile and potency of hand-rubbed hashish collected from 20 regions of the northwest Himalayas.

Spatio-temporal distribution and source contributions of the ambient pollutants in Lucknow city, India.

Clean air is imperative to the survival of all life forms on the planet. However, recent times have witnessed enormous escalation in urban pollution levels. It is therefore, incumbent upon us to decipher measures to deal with it.

Formulation and Characterization of Silibinin Entrapped Nano-Liquid Crystals for Activity against Aβ Neurotoxicity in In-Vivo Model.

Silibinin (SIL) Encapsulated Nanoliquid Crystalline (SIL-NLCs) particles were prepared to study neuroprotective effect against amyloid beta (Aβ) neurotoxicity in Balb/c mice model. Theses NLCs were prepared through hot emulsification and probe sonication technique. The pharmacodynamics was investigatigated on Aβ intracerebroventricular (ICV) injected Balb/c mice.

Association of socio-demographic factors with clinical outcome among hospitalized patients in first and second waves of COVID-19 pandemic: Study from the developing world.

Background: Recent disease resurgence in China indicates that corona virus infectious disease is still a pertinent public health problem. We stand at a juncture where we are still unsure about the initial dilemmas regarding its birth, therapies, and the emerging novel strains. Medical literature has focused on the clinical, laboratory, radiological, and therapeutic aspects of disease management.