Impact of Ligand Structure on Biological Activity and Photophysical Properties of NHC-Protected Au Nanoclusters.

N-heterocyclic carbene (NHC)-protected gold nanoclusters display high stability and high photoluminescence, making them well-suited for fluorescence imaging and photodynamic therapeutic applications. We report herein the synthesis of two bisNHC-protected Au nanoclusters with π-extended aromatic systems. Depending on the position of the π-extended aromatic system, changes to the structure of the ligand shell in the cluster are observed, with the ability to correlate increases in rigidity with increases in fluorescence quantum yield.

Comparative evaluation of bone density after implant placement using cone-beam CT analysis in augmented versus non-augmented.

Introduction: Dental implants are the most popular alternative to rehabilitation of missing teeth and oro-facial structures. The outcome of such procedures depends on various factors and most-importantly on the osseo-integation with the surrounding bone. The evaluation needs better visualization and evaluation using CBCT anaylsis and determination of HU, using an appropriate software.

Novel Technique for Fracture Fixation of the Patella Following Unicondylar Knee Replacement: A Clinical Case Report.

Introduction: Unicondylar knee replacement (UKR) is a surgical procedure frequently performed to treat medial compartment osteoarthritis, offering advantages such as quicker recovery and preservation of knee kinematics. However, complications can arise, including periprosthetic fractures. Patella fractures in the context of UKR are particularly challenging due to the presence of the implant.

Artificial intelligence as a proficient tool in detecting pulmonary tuberculosis in massive population screening programs: a case study in Chennai, India.

Objective: To evaluate the performance of Genki, a computer-aided detection (CADe) software, in detecting tuberculosis (TB) using chest radiography in a mobile TB screening program in Chennai, India.

Materials And Methods: Genki, an AI-based CADe software, was employed in four mobile diagnostic units in remote areas of Chennai, India for screening TB. Patients from remote areas of Chennai who visited the vans and registered in the screening program underwent chest radiography, and the acquired X-ray scans were analyzed using Genki, which provided an assessment of each scan as either "TB suggestive" or "TB not suggestive".

Discordance of 3rd and 4th generation QuantiFERON-TB Gold assays by pregnancy stages in India.

Background: Pregnancy and HIV affect CD4+ T lymphocytes and impact performance of QuantiFERON-TB Gold (QFT). We compared the results of QFT with QuantiFERON-TB Gold Plus (QFT-Plus), which also measures CD8+ responses to TB antigens, during pregnancy and postpartum.

Methods: We screened 516 pregnant women for TB infection (TBI) with IGRA.

Generalizing from qualitative data: a case example using critical realist thematic analysis and mechanism mapping to evaluate a community health worker-led screening program in India.

Background: A central goal of implementation science is to generate insights that allow evidence-based practices to be successfully applied across diverse settings. However, challenges often arise in preserving programs' effectiveness outside the context of their intervention development. We propose that qualitative data can inform generalizability via elucidating mechanisms of an intervention.

Role of Pre-operative Correction of Vitamin D3 Deficiency in Controlling Post-operative Bone Pain after Unicompartmental Knee Arthroplasty.

Introduction: Hypovitaminosis D plays an important role in post-operative bone pain and muscle strength in arthroplasty surgeries. Its role in unicompartmental knee arthroplasty (UKA) has not been elucidated yet. The objective of this study was to determine the impact of hypovitaminosis D and its correction on post-operative bone pain after UKA.

Baseline characteristics of patients with degenerative cervical myelopathy in Australia: analysis from the MYelopathy NAtural History registry.

Background: Degenerative Cervical Myelopathy (DCM) is the most common cause of non-traumatic, chronic spinal cord dysfunction worldwide, causing debilitating disability with a diminishing quality of life. The natural history of DCM is poorly understood. This is a preliminary report of the first 60 patients recruited to the MYelopathy NAtural History (MYNAH) Registry.

Predictive metabolite signatures for risk of progression to active TB from QuantiFERON supernatants of household contacts of TB patients.

The identification of individuals with the greatest risk of progression to active tuberculosis (TB) disease from the huge reservoir of () infected individuals continues to remain an arduous ascent in the global effort to control TB. In a two-year prospective study, we analysed metabolic profiles in the unstimulated and TB antigen stimulated QuantiFERON supernatants of 14 healthy household contacts (HHCs) who progressed to TB disease (Progressors) and 14 HHCs who remained healthy (Non-Progressors). We identified 21 significantly dysregulated metabolites in the TB antigen-stimulated QuantiFERON supernatants of Progressors, of which the combination of Malic acid and N-Arachidonoylglycine had maximum AUC of 0.

Navigating the Diagnostic Labyrinth of Scrofuloderma Orbit in Conjunction with Jungling's Disease.

Tuberculosis (TB) manifests in various forms, including extrapulmonary tuberculosis (EPTB), which poses diagnostic dilemmas due to its wide-ranging clinical presentations. When TB affects the bones of the hands and feet, it can present a diagnostic labyrinth for clinicians. In such cases, the differential diagnosis may include Jungling's bone disease, adding complexity to the diagnostic process.

Toxicity profile of standardized Krishna Vajra Abhraka bhasma made from biotite mica.

Introduction: The Bhasmas, herbo-minerals, are reported to produce adverse effects when used clinically. Therefore, the present study aimed to assess the safety of Krishna Vajra Abhraka Bhasma (KVB), through acute and subacute toxicity testing.

Materials And Methods: After ethics committee approval, total 66 Wistar albino rats weighing 180-200 gms were used.

IoT-based automated system for water-related disease prediction.

Having access to potable water is a fundamental right to well-being. Despite this, 3.4 million people die from diseases caused by water each year, and 1.

Streptococcus constellatus Empyema: A Case Highlighting the Need for Timely Surgical Intervention.

This case report explores the intricate challenges of diagnosing and managing empyema caused by , particularly in patients with predisposing factors such as alcohol abuse and underlying respiratory conditions. We present a 34-year-old male patient with a medical history of hypertension, peripheral neuropathy, and alcohol abuse who developed empyema. Despite an initial presentation at another facility with symptoms mimicking a myocardial infarction and unremarkable chest X-ray results, his condition worsened, leading to a subsequent emergency department visit.

Advancements in Ocular Therapy: A Review of Emerging Drug Delivery Approaches and Pharmaceutical Technologies.

Eye disorders affect a substantial portion of the global population, yet the availability of efficacious ophthalmic drug products remains limited. This can be partly ascribed to a number of factors: (1) inadequate understanding of physiological barriers, treatment strategies, drug and polymer properties, and delivery systems; (2) challenges in effectively delivering drugs to the anterior and posterior segments of the eye due to anatomical and physiological constraints; and (3) manufacturing and regulatory hurdles in ocular drug product development. The present review discusses innovative ocular delivery and treatments, encompassing implants, liposomes, nanoparticles, nanomicelles, microparticles, iontophoresis, in situ gels, contact lenses, microneedles, hydrogels, bispecific antibodies, and gene delivery strategies.

Dynamic changes in macrophage polarization during the resolution phase of periodontal disease.

Aim: Polarization of macrophages (Mφ) is a well-controlled axis with considerable consequences in both the pro-inflammatory and resolution phases of inflammation. We aimed to determine if periodontal therapy may instigate M1 to M2 Mφ polarization favoring resolution of inflammation within periodontal tissues.

Methods: Gingival biopsies were excised from subjects diagnosed with Stage III, Grade B periodontitis before and 4-6 weeks after nonsurgical periodontal therapy.

Retrospective analysis of volumes of manually expressed colostrum among healthy postnatal mothers at a tertiary care referral unit in South India. Not enough milk or not enough patience?

Introduction: The volumes of colostrum have been quantified as 5 mL and 25 mL per feed on days 1 and 3, respectively, as per the data described about 20 years ago. However, the use of commercial formula is on the rise and 'not enough milk' is a common complaint by postnatal mothers.

Objectives: To determine the average volume of colostrum in one sitting per day on first three postnatal days among healthy late preterm and term gestational mothers and to compare the same among late preterm, term gestation and modes of delivery.

Acceptability and validity of HPV self-sampling for cervical cancer screening among women living in different ecological settings in India.

India records one fifth of global cervical cancer burden. Unlike human papillomavirus (HPV) self-sampling, other screening methods may cause discomfort and embarrassment. This study aimed to investigate attitudes, acceptability, barriers, predictors, effective modality of instructions, and validity of HPV self-sampling among Indian women residing in varied settings and different literacy levels.