Publications by authors named "Kuljit Singh"

Leishmaniasis is a neglected tropical disease and is one of the major causes of mortality in poverty-stricken areas. A limited chemotherapeutics arsenal is available to tackle this deadly infection. Thus, identifying novel potent scaffolds using innovative strategies is the need of the hour.

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Article Synopsis
  • Anti-microbial resistance in pathogens poses a significant threat to human health, leading to increased illness, death, and healthcare costs, especially in hospitals.
  • Specifically, Gram-negative bacteria from the ESKAPE group, known for causing various severe infections, have become adept at surviving antibiotic treatments, creating challenges for infection control.
  • The review discusses innovative strategies in drug discovery, including combinational therapy, high-throughput screening, and drug repurposing, to develop new approaches against these drug-resistant bacteria.
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Correction for 'Chromatographic fingerprinting of epiphytic fungal strains isolated from and biological evaluation of isolated okaramine H' by Vandana Sharma , , 2024, https://doi.org/10.1039/D4AY00901K.

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Background: Low-dose colchicine reduces the risk of cardiovascular events after myocardial infarction (MI). The purpose of this study was to assess the effect of colchicine post-MI on coronary plaque morphology in non-culprit segments by optical coherence tomography (OCT).

Methods And Results: COCOMO-ACS was a double-blind, placebo-controlled trial that randomized 64 patients (median age 61.

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  • This study investigates natural products for their ability to kill Leishmania parasites, an important area due to the diverse compounds they offer.
  • Out of 560 natural molecules tested, 38 showed over 50% effectiveness at a concentration of 50µM, with six showing dose-dependent activity at much lower concentrations.
  • Molecular docking revealed that two compounds, shatavarin IV and 6-methoxydihydrochelerythrine, strongly bind to a specific enzyme in the parasite, blocking its sterol biosynthesis and thus inhibiting parasite growth.
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Medicinal plants are "goldmines" of natural products, and continue to provide key scaffolds for drug development. They have immense therapeutic potential, encapsulating a plethora of metabolites within them, which have yet to be explored. (L.

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Leishmaniasis is a disease caused by the parasite Leishmania donovani affecting populations belonging to developing countries. The present study explores drug repurposing as an innovative strategy to identify new uses for approved clinical drugs, reducing the time and cost required for drug discovery. The three-dimensional structure of Leishmania donovani Sterol C-24 methyltransferase (LdSMT) was modeled and 1615 FDA-approved drugs from the ZINC database were computationally screened to identify the potent leads.

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High systolic blood pressure (HSBP) is associated with several metabolic and non-metabolic disorders. This research aimed to document the deaths and disability-adjusted life-years (DALYs) attributable to HSBP in the Middle East and North Africa (MENA) region between 1990 and 2019, by age, sex, underlying cause and socio-demographic index (SDI). We used the methodological framework and data drawn from the Global Burden of Disease study 2019 to identify the burden of diseases attributable to HSBP, from 1990 to 2019, in the MENA region.

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Parthenium hysterophorus plant has a diverse chemical profile and immense bioactive potential. It exhibits excellent pharmacological properties such as anti-cancer, anti-inflammatory, anti-malarial, microbicidal, and anti-trypanosomal. The present study aims to evaluate the anti-leishmanial potential and toxicological safety of anhydroparthenin isolated from P.

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We present three cases of acute coronary obstruction postsurgical repair of type A aortic dissection, which were successfully treated with percutaneous coronary intervention. We describe a step-by-step approach to performing percutaneous coronary intervention in selective cases of coronary obstruction related to type A aortic dissection.

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Understanding the unique metabolic pathway of L. donovani is crucial for comprehending its biology under oxidative stress conditions. The de novo cysteine biosynthetic pathway of L.

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  • * The optimized nano-emulsion showed a small droplet size of about 44.19 nm and high drug encapsulation efficiency, with over 83% of AmB successfully incorporated.
  • * Compared to pure AmB, the nano-emulsion demonstrated significantly better inhibition of leishmanial parasites and maintained stability under various conditions, suggesting it could be a promising treatment for visceral leishmaniasis.
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Most bacteria, including mycobacteria, generate extracellular vesicles (EVs). Since bacterial EVs (bEVs) contain a subset of cellular components, including metabolites, lipids, proteins, and nucleic acids, several groups have evaluated either the native or recombinant versions of bEVs for their protective potency as subunit vaccine candidates. Unlike native EVs, recombinant EVs are molecularly engineered to contain one or more immunogens of interest.

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Leishmaniasis, caused by a protozoan parasite, is among humanity's costliest banes, owing to the high mortality and morbidity ratio in poverty-stricken areas. To date, no vaccine is available for the complete cure of the disease. Current chemotherapy is expensive, has undesirable side effects, and faces drug resistance limitations and toxicity concerns.

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Background: Rheumatic heart disease (RHD) is a treatable and preventable condition resulting from acute rheumatic fever.

Aim: To report the prevalence, mortality and disability-adjusted life-years (DALY) due to RHD in the Middle East and North Africa (MENA) region from 1990 to 2019, by sex, age group, country and sociodemographic index (SDI).

Methods: Information on the prevalence, mortality and DALY associated with RHD were obtained from the Global Burden of Disease Study 2019.

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Leishmaniasis, one of the neglected diseases, ranks second to malaria in the cause of parasitic mortality and morbidity. The present chemotherapeutic regimen faces the limitations of drug resistance and toxicity concerns, raising a great need to develop new chemotherapeutic leads that are orally administrable, potent, non-toxic, and cost-effective. Several research groups came forward to fill this therapeutic gap with new classes of active compounds against leishmaniasis, one such being 3,3'-diindolylmethane (DIM) derivatives.

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Until recently, it has been generally held that stable angina pectoris (SAP) primarily reflects the presence of epicardial coronary artery stenoses due to atheromatous plaque(s), while acute myocardial infarction (AMI) results from thrombus formation on ruptured plaques. This concept is now challenged, especially by results of the ORBITA and ISCHEMIA trials, which showed that angioplasty/stenting does not substantially relieve SAP symptoms or prevent AMI or death in such patients. These disappointing outcomes serve to redirect attention towards anomalies of small coronary physiology.

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Article Synopsis
  • - Transradial access (TRA) is increasingly preferred for coronary procedures, but one concern is radial artery occlusion (RAO), which can complicate future procedures.
  • - The Rivaroxaban Post-Transradial Access trial aims to study if taking rivaroxaban after TRA can lessen the chance of RAO by comparing its effects against no postprocedural anticoagulation.
  • - This study is ethically approved and aims to share its findings through conferences and publications, ensuring transparency in the research process.
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Importance: The use of F-FDG PET/CT in diagnostic algorithms for PVE has increased since publication of studies and guidelines advocating its use. The assessment of test accuracy has been limited by small study sizes. We undertook a systematic review using individual patient data (IPD) meta-analysis techniques.

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Leishmaniasis, a tropically neglected disease, is responsible for the high mortality and morbidity ratio in poverty-stricken areas. Currently, no vaccine is available for the complete cure of the disease. Current chemotherapeutic regimens face the limitations of drug resistance and toxicity concerns indicating a great need to develop better chemotherapeutic leads that are orally administrable, potent, non-toxic, and cost-effective.

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Background: Parkinson's disease (PD) remains a common disabling progressive neurodegenerative disorder. We aimed to report the prevalence, death and disability-adjusted life-years (DALYs) attributable to PD in the Middle East and North Africa (MENA) region and its 21 countries by age, sex and socio-demographic index (SDI), between 1990 and 2019.

Methods: Publicly available data on the burden of PD in the MENA countries were retrieved from the Global Burden of Disease (GBD) 2019 project.

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Tocilizumab is an interleukin (IL)-6 receptor inhibitor that has been proposed as a therapeutic agent for treating coronavirus disease 2019 (COVID-19). The aim of this umbrella review was to determine the efficacy of tocilizumab in treating COVID-19, and to provide an overview of all systematic reviews on this topic. We systematically searched PubMed, Scopus, the Web of Science collection, the Cochrane library, Epistemonikos, and Google Scholar, as well as the medRxiv preprint server.

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In response to osmotic shock, the components of high-osmolarity glycerol (HOG) pathway regulate the level of intracellular glycerol in yeast and ensure cell survival. Glycerol is a compatible solute and a stabiliser of proteins. Its role in maintaining proteostasis is less explored.

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  • The management of allergic rhinitis (AR) aims for effective symptom control to improve patients' quality of life, primarily through medication.
  • There are knowledge gaps among physicians regarding pharmacotherapy use, especially in primary care, and uncertainty about new combination therapies in secondary care.
  • To address these issues, a consensus statement has been created to enhance existing guidelines for the rational use of pharmacotherapy in both primary and secondary healthcare settings.
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Leishmaniasis is a neglected tropical disease and remains a global concern for healthcare. It is caused by an opportunistic protozoan parasite belonging to the genus Leishmania and affects millions worldwide. This disease is mainly prevalent in tropical and subtropical regions and is associated with a high risk of public morbidity and mortality if left untreated.

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