[The functional status of circulating lymphoid and phagocytic cells in patients with tropical malaria, living in the endemic areas of Guinea].

The paper presents the results of a study of immunological parameters in the indigenous adult population of an endemic area of Guinea in tropical malaria of varying severity and the time course of changes in these parameters in different phases of the disease during delagil treatment. Examination of 101 patients has established that tropical malaria in re-infected patients is not accompanied by severe immunosuppression though there is a clear tendency towards lymphocytic immunodeficiency in patients with higher parasitemia and a severe course of the disease. The greatest manifestations of immunosuppression coincide with the high oxygen metabolism of phagocytes, which confirms their important role in the pathogenesis of immune disorders and common syndrome in malaria.

[Effect of heparin on the activation of the anticoagulation system by alpha-thrombin].

Heparin-regulated alpha-thrombin ability to activate the response of the anticoagulation system has been studied by the perfusion of sinocarotid area of rabbits with DIP-alpha-thrombin-heparin complex. In a series of experiments the area was perfused with 1.8 micron DIP-alpha-thrombin and significant changes in anticoagulation parameters have been registered in systemic circulation.

[Prevention of intravascular blood coagulation in rats by DIP-alpha-thrombin administration].

The possibility of prevention of intravascular blood coagulation in rats by DIP-alpha-thrombin devoid of proteolytic activity and capable of stimulating the reaction of anticoagulation system was studied. The injection of lethal thromboplastin dose was shown to produce a sharp increase in soluble fibrin blood content, total disappearance of fibrinolytic activity and intravascular blood coagulation. The animals died of thrombosis in 90% of cases.

[Heparin-induced impairment of thrombin interaction with fibrinogen and receptors of the anti-coagulation system].

Administration of heparin (2 un) into rats with depression of the anticoagulation system before treatment of the animals with alpha-thrombin (8 NIH un) inhibited the enzyme interaction with blood fibrinogen, which was manifested as a distinct decrease in content of soluble fibrin in blood as compared with its concentration evaluated after the treatment with thrombin. Heparin inhibited the reaction of thrombin with specific receptors in vascular walls. The effector response of the anticoagulation system, which is specific for interaction of free alpha-thrombin with the cell wall receptors, was not observed if thrombin was administered intravenously together with heparin.

[Heparin secretion by mast cells as an index of the status of the anticoagulant system].

The status of the mast cell population was studied and compared after administration of trypsin or alpha-thrombin in similar molar concentrations. Morphometry disclosed a substantial shift of the mast cell population towards light, heparin-free cells within one minute after alpha-thrombin administration. The index of mast cell saturation with heparin dropped below 1.