[Effect of various approaches to therapy with statins in high risk patients from the point of view of vascular endothelium].

In a framework of multicenter study ATLANTIKA in a group of patients we carried out noninvasive ultrasound test of endothelium dependent vasodilatation (EDVD) of brachial artery before and at the background of therapy with atorvastatin. Aim of the study was to assess and compare effects of incremental (10-80 mg/day) and stable (10 mg/day) doses of atorvastatin on functional state of endothelium. The group of observation comprised 148 patients A 86 men, 62 women aged 59.

[Randomized FARVATER study. Part 2. Effect of atorvastatin on endothelial function, distensibility and stiffness of vascular wall].

Aim: To elucidate effect of two doses of atorvastatin (10 and 20 mg/day) on endothelial function, distensibility and stiffness of vascular wall.

Material And Methods: Patients (n=50) with documented ischemic heart disease and hyperlipidemia were randomized to 10 or 20 mg/day of atorvastatin (Atoris, KRKA). Endothelial function and common carotid artery wall distensibility and stiffness were assessed at baseline and after 12 and 24 weeks of treatment.