Molecular encapsulation of andrographolide in 2-hydroxypropyl--cyclodextrin cavity: synthesis, characterization, pharmacokinetic and antiviral activity analysis against SARS-CoV-2.

In present investigation, AND-2-HyP--CYD (Andrographolide-2-Hydroxypropyl--cyclodextrin) complex was synthesized and characterized for antiviral and pharmacokinetic profile. The linear host-guest relation suggested synthesis of a 1:1 complex of AND with 2-HyP--CYD by inclusion mode. The Kc, stability constant of the two phase system of AND with 2-HyP--CYD computed to be 38.