Relationships of Lower-body Power Measures to Sprint and Change of Direction Speed among NCAA Division II Women's Lacrosse Players: An Exploratory Study.

This study sought to determine if significant relationships exist between lower-body power measures to sprint and change of direction speed (CODS) in Division II collegiate women's lacrosse athletes. Archived data for 17 NCAA Division II female lacrosse athletes was provided to the investigators for analysis. Jumping performance was assessed using a countermovement jump (CMJ), squat jump (SJ), and standing broad jump (SBJ).

Taurine binding to the purified insulin receptor.

Taurine (2-aminoethanesulfonic acid) was shown to bind specifically and reversibly to the purified human insulin receptor. While insulin binding to the purified insulin receptor exhibited characteristic negative cooperativity and an apparent dissociation constant (Kd) of 1.2 X 10(-9) M, taurine binding was shown to exhibit positive cooperativity and had a lower affinity for the insulin receptor.

Naloxone reverses the serotonin dependent hypotensive action of CGP 6085 A.

CGP 6085 A, a specific 5-hydroxytryptamine (5-HT), serotonin uptake inhibitor, is also a potent hypotensive agent. Its depressor effect in the spontaneously hypertensive (SH) rats correlates well with its ability to inhibit serotonin uptake. Here we report that the effects of CGP 6085 A on arterial blood pressure were greatly reduced in rats pretreated with p-chlorophenylalanine (pCl-Phe), a specific depletor of serotonin.

Inhibition of rat brainstem monoamine oxidase activity by CGP 6085 A.

CGP 6085 A [4-(5,6-dimethyl-2-benzofuranyl)piperidine] HCl, a known serotonin inhibitor, also inhibits rat brainstem monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) in both in vivo and in vitro experiments. Serotonin (5-HT) deamination by MAO-A is inhibited 35% at a dose of 100 mg/kg i.p.

Enhanced sympathetic-adrenal medullary response to cold exposure in spontaneously hypertensive rats.

To investigate the regulation of sympathetic-adrenal medullary function in spontaneously hypertensive (SHR) male rats, we measured urinary catecholamine excretion for 4 h at room temperature and also during cold exposure (4 degrees C) in groups of four and 12-week-old stroke-prone SHR (SHRSP), stroke-resistant SHR (SHRSR) and normotensive Wistar-Kyoto (WKY) rats. The effect of cold exposure on 12-week-old adrenal denervated rats was also examined. At room temperature, urinary excretion of epinephrine, but not norepinephrine or dopamine, was increased significantly in four-week-old SHRSP and SHRSR rats compared with age-matched WKY.

The hypotensive action of 4-(5,6-dimethyl-2-benzofuranyl) piperidine HCl (CGP 6085 A) in spontaneously hypertensive rats.

CGP 6085 A, [4-(5,6-dimethyl-2-benzofuranyl)piperidine HCl], has been found to be a mild to moderately potent hypotensive agent. One hour following CGP 6085 A administration (10 mg/kg, i.p.

The hypothermic effect of 4-(5,6-dimethyl-2-benzofuranyl) piperidine HCl (CGP 6085 A) in Wistar Kyoto rats.

CGP 6085 A [4-(5,6-dimethyl-2-benzofuranyl) piperidine HCl], a reported serotonin uptake and MAO (16) inhibitor, is a potent hypothermic agent. The hypothermic action of CGP 6085 A is dose dependent with a maximal reduction in rectal core temperature of greater than 1 degree C within one hour after drug administration. Fluoxetine and citalopram elicit a similar response at equal doses.

Hypoglycemic properties of taurine: not mediated by enhanced insulin release.

Taurine (2-aminoethanesulfonic acid) has been shown to be a potent hypoglycemic agent in the Wistar Kyoto rat (WKY). Glucose and insulin levels were measured in serum at various times after glucose loading (400 mg/kg, i.p.

Action of substance P on the working rat heart.

The effect of substance P (SP) on the cardiodynamics of the isolated working rat heart perparation was examined. The peptide over the concentration range of 10(-8) to 10(-6) M was found to have no influence on aortic pressure, cardiac output, or cardiac work. However, a 10-15% reduction in coronary flow was observed at 1 x 10(-6) M substance P.

Taurine enhancement of calcium binding to rat heart sarcolemma.

The effect of taurine on calcium binding to isolated rat heart sarcolemmal membrane was examined. Taurine was observed to increase calcium binding to the low affinity sites in both high sodium-low potassium and low sodium-high potassium buffers. Taurine was also seen to antagonize the inhibition of calcium binding to the sarcolemma caused by both verapamil and lanthanum.