[Preferred distances between DNA binding sites for factors regulating transcription initiation].

Transcriptional regulation of gene expression in higher eukaryotes is driven by sophisticated protein complexes of transcription factors. On the DNA level, there are composite elements containing sites of different DNA-binding proteins. We use the hypoxia-response system to identify preferred localization distances for the 'hypoxia-induced factor-1 binding site-co-factor binding site" pairs in promoter DNA regions of the human genome.

[Integration of data obtained by different experimental methods to determine the motifs in DNA sequences recognized by transcription-regulating factors].

For 39 proteins regulating the transcription of Drosophila melanogaster, refined motifs typical for nucleotide sequences specifically interacting with these proteins have been constructed using the new logarithm ChiPMunk. The entire spectrum of available experimental data, including the data of DNAse footprinting, SELEX, ChIP-chip, and B1H-system, has been used. Motifs constructed by integrating the data obtained by independent experimental methods show the highest sensitivity.

[The dynamic nature and age-related dependence of functional brain organization in attention].

Intrahemispheric functional organization was studied during a task expectancy period with special reference to attention mechanisms. The estimation of coherence of functionally identical rhythmic EEG components was made to characterize the intracortical integration. Several factors influencing the possibility to make an adequate prognosis and to realize it were varied.