Prevalence and risk factors of sleep breathing disorders in patients with acromegaly from Moscow region.

Aim: Assessment of prevalence and risk factors of sleep breathing disorders in patients with acromegaly from Moscow region.

Materials And Methods: Cardiorespiratory monitoring was executed to 55 patients with acromegaly (18 men and 37 women): 27 patients with de novo disease, 28 patients on treatment of acromegaly (including 18 patietns with uncontrolled and 10 - with controlled acromegaly). All subgroups did not differ on sex, BMI and age.

[Effect of the rhythm of administration of 1,2-dimethylhydrazine on its carcinogenic action].

The regimen of DMH treatment with the same total dose influenced the realization of its carcinogenic effect. The most extensive intestinal tumours were observed when DMH was administered once a week in a dose of 21 mg/kg of body weight. Daily treatment in a dose of 3 mg per kg results in development of a less marked malignant tumour process restricted to the colon alone.