Publications by authors named "Kulachet Wiwatwarayos"
Assessing the relationship between tumor-infiltrating lymphocytes and PD-L1 expression in triple negative breast cancer: Identifying optimal TILs cut-off value for pathologic reporting.
Ann Diagn Pathol
June 2024
Background: Triple Negative Breast Cancer (TNBC) presents diagnostic complexities, particularly in evaluating Tumor-Infiltrating Lymphocytes (TILs) and Programmed Death-Ligand 1 (PD-L1) expression. This study aimed to identify optimal TILs percentage cut-offs predictive of PD-L1 expression and to investigate the relationship between TILs, PD-L1, and tertiary lymphoid structures (TLSs).
Method: Analyzing 141 TNBC cases, we assessed TILs, PD-L1 expression (clones 22C3 and SP142), and TLS presence.
A Biochemical and Pharmacological Characterization of Phospholipase A and Metalloproteinase Fractions from Eastern Russell's Viper () Venom: Two Major Components Associated with Acute Kidney Injury.
Toxins (Basel)
July 2021
Article Synopsis
- Acute kidney injury (AKI) is a major symptom in victims of Eastern Russell's viper envenoming, largely due to specific venom components that cause nephrotoxicity.
- The study identified two purified proteins, RvPLA (snake venom phospholipase A) and RvMP (a factor X activator), which were linked to harmful effects on organs including the kidneys, heart, and spleen.
- Findings suggest that RvPLA and RvMP contribute significantly to AKI and related symptoms in envenomed victims, highlighting the need for updated treatment strategies to address their potential irreversible nephrotoxicity.
Evaluation of the geographical utility of Eastern Russell's viper (Daboia siamensis) antivenom from Thailand and an assessment of its protective effects against venom-induced nephrotoxicity.
PLoS Negl Trop Dis
October 2019
Background: Daboia siamensis (Eastern Russell's viper) is a medically important snake species found widely distributed across Southeast Asia. Envenomings by this species can result in systemic coagulopathy, local tissue injury and/or renal failure. While administration of specific antivenom is an effective treatment for Russell's viper envenomings, the availability of, and access to, geographically-appropriate antivenom remains problematic in many rural areas.
View Article and Find Full Text PDFNon-neurotoxic activity of Malayan krait () venom from Thailand.
J Venom Anim Toxins Incl Trop Dis
March 2018
Background: Envenoming by kraits (genus ) is a medically significant issue in South Asia and Southeast Asia. Malayan krait () venom is known to contain highly potent neurotoxins. In recent years, there have been reports on the non-neurotoxic activities of krait venom that include myotoxicity and nephrotoxicity.
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