Widespread involvement of hepatic, renal and mesenteric arteries with multiple mycotic aneurysms in a child.

Multiple visceral microaneurysms of mycotic origin are very uncommon. We present an 11-year-old child with the clinical and biochemical signs of septicemia in whom arteriographic study revealed multiple microaneurysms of renal, hepatic, gastroduodenal, ileocolic and right colic arteries. Six weeks of antibacterial treatment resulted in resolution of the septicemia and most of the aneurysms healed without the need for endovascular or surgical treatment.

Are glutathione S-transferase gene polymorphisms linked to neonatal jaundice?

Glutathione S-transferases (GSTs) are a major group of phase II detoxification enzymes involved in the metabolism of both endogenous and xenobiotic compounds. In addition to their catalytic function in detoxification, GSTs participate in binding to nonsubstrate ligands such as bilirubin. Ligandin, which is one of the principal hepatic-binding proteins, is also a member of the GST family.

The frequency of UDP-glucuronosyltransferase 1A1 promoter region (TA)7 polymorphism in newborns and it's relation with jaundice.

Increased bilirubin formation and decreased bilirubin conjugation play an important role in the pathogenesis of the newborn jaundice. Although physiologic jaundice is seen in most of the newborns, there are many risk factors that affect the severity and duration of hyperbilirubinemia. The latest studies showed that the frequency and severity of neonatal jaundice have been increased when mutations of the gene coding UDP-glucuronosyltransferase(UGT)1A1 coexist with other risk factors.

MDCT cholangiography with volume rendering for the assessment of patients with biliary obstruction.

Objective: We sought to evaluate the diagnostic utility of MDCT cholangiography with volume rendering in the evaluation of patients with suspected biliary tree obstruction.

Subjects And Methods: MDCT was performed in 34 patients who were thought to have biliary obstruction. Portal venous phase scanning was initiated 70 sec after the IV infusion of 150 mL of contrast agent, and no cholangiographic contrast agent was administered.