Employing the Trifluoromethyl Group on a 5/5 Fused Triazolo[4,3-][1,2,4]triazole Backbone: A Viable Strategy for Attaining Balanced Energetics.

In this study, we synthesized trifluoromethyl-substituted bis-triazole nitrogen-rich compounds (-) using a simple, cost-effective method. The newly made compounds were characterized using NMR, IR, elemental analysis, TGA-DSC, and single-crystal X-ray diffraction (for compounds and ). They demonstrated high density (1.

Evaluation of immunisation coverage and its determinants among children aged 12-23 months in urban slum areas of Jhalawar city.

Background: Immunisation services does not reach over one third of urban poor children. There is clear cut difference of children completely immunised in the low as compared to high standard of living index in urban areas. This difference is more marked in low performing states like Rajasthan and this difference as compared to better performing states like Kerala.

Symmetric Refunctionalization of Diaminodinitropyrazine with Hydrazine and Aminotetrazole: Strategy for Enhancing Detonation Performance and Safety in Energetic Materials.

Two novel nitrogen-rich green energetic compounds were synthesized for the first time from readily available and cost-effective pyrazine starting materials. All newly synthesized molecules were comprehensively characterized, including infrared spectroscopy, nuclear magnetic resonance, elemental analysis, mass spectrometry, and thermogravimetric analysis-differential scanning calorimetry. All compounds have additionally been validated by single-crystal X-ray diffraction analysis.

Association of Social Support and Metabolic and Bariatric Surgery Completion Among Racially and Ethnically Diverse Patients.

Purpose: Metabolic and bariatric surgery (MBS) is presently the most evidence-based, effective treatment of obesity. Nevertheless, only half of the eligible individuals who are referred for this procedure complete it. This study aims to investigate the association between social support and MBS completion, considering race and ethnicity.

To Evaluate the Efficacy of Biomarkers as Monitoring Tool in Patients with Fascial Space Infections of Odontogenic Origin: A Clinical Study.

Introduction: The objective was to evaluate the efficacy of biochemical markers (WBC, CRP and fibrinogen) and the course of odontogenic space infections in 50 patients.

Material And Methods: Blood samples were taken preoperatively and postoperatively at day 0, day 4, day 8 and day 12 for measuring the levels of all three biomarkers. The trends of the biomarkers were observed and compared with assessment parameters such as dental etiology, number of teeth involved, number of spaces involved, mouth opening and pain.

Factors Associated with the Decision to Complete Bariatric Metabolic Surgery among a Racially and Ethnically Diverse Sample of Adults: A Classification and Regression Tree Analysis.

Background: Less than 50% of eligible candidates who are referred complete Bariatric Metabolic Surgery (BMS). The factors influencing the decision to complete BMS, particularly how these factors vary across different racial and ethnic groups, remain largely unexplored.

Methods: This prospective cohort study included adult patients referred to a bariatric surgeon or obesity medicine program between July 2019-September 2022.

Postoperative delirium in 47 379 individuals undergoing transcatheter aortic valve replacement: a systematic review and meta-analysis.

Objective: The study aims to discuss the assessment methods used for the incidence of in-hospital postoperative delirium (IHPOD) in transcatheter aortic valve replacement (TAVR) patients and explore possible strategies for preventing and reducing postoperative complications in the geriatric population.

Methodology: An electronic search of PubMed, Embase, BioMedCentral, Google Scholar, and the Cochrane Central Register of Controlled Trials was conducted up to August 2021, to identify studies on the IHPOD following TAVR in patients above 70 years. The primary objective of the study was to determine the incidence of delirium following TAVR and procedures like transfemoral (TF) and non-TF approaches.

Lack of knowledge regarding the misuse of domperidone in Pakistan and its serious consequences: short communication.

Domperidone is an antagonist of the peripheral dopamine (D2) receptor. It works as an antiemetic by blocking D2-receptors at the chemoreceptor trigger zone and as a gastroprokinetic drug by blocking GI tract D2-receptors. According to research, using domperidone significantly raises the risk of cardiac arrhythmia and sudden cardiac death by 70%, most likely through prolonging the QT interval.

Autoimmune hemolytic anemia, a rare disease in newborns: a case report.

Unlabelled: Autoimmune hemolytic anemia (AIHA) is a type of hemolytic anemia in which autoantibodies attack the membrane antigens of red blood cells, causing cell rupture (lysis). Hemolysis stimulates compensatory RBC production by boosting erythropoietin levels; however, this response is often insufficient to restore normal hemoglobin blood levels, resulting in anemia. It is a rare disease, with an annual incidence of one case in every 80 000 live births.

Depression and Anxiety as Predictors of Metabolic and Bariatric Surgery Completion Among Ethnically Diverse Patients.

Background: Mental health conditions including depression and anxiety are often prevalent among metabolic and bariatric surgery (MBS) patients, but it is not known if these conditions predict the decision to complete the procedure and if this varies by race and ethnicity. This study aimed to determine if depression and anxiety are associated with MBS completion among a race/ethnically diverse sample of patients.

Methods: This prospective cohort study included participants who were referred to an obesity program or two MBS practices between August 2019 and October 2022.

Nasogastric vs Orogastric Feeding in Stable Preterm (≤32 Weeks) Neonates: A Randomized Open-Label Controlled Trial.

Background: Optimal route of tube feeding in preterm babies is not known.

Objectives: To compare the frequency of bradycardia and desatu-ration episodes/hours in hemodynamically stable preterm neo-nates (≤32 wk gestational age) fed by nasogastric vs orogastric route.

Design: Randomized controlled trial.

Evidence for RNA or protein transport from somatic tissues to the male reproductive tract in mouse.

The development of tools to manipulate the mouse genome, including knockout and transgenic technology, has revolutionized our ability to explore gene function in mammals. Moreover, for genes that are expressed in multiple tissues or at multiple stages of development, the use of tissue-specific expression of the Cre recombinase allows gene function to be perturbed in specific cell types and/or at specific times. However, it is well known that putative tissue-specific promoters often drive unanticipated 'off-target' expression.

A Heuristic Machine Learning-Based Optimization Technique to Predict Lung Cancer Patient Survival.

Cancer has been a significant threat to human health and well-being, posing the biggest obstacle in the history of human sickness. The high death rate in cancer patients is primarily due to the complexity of the disease and the wide range of clinical outcomes. Increasing the accuracy of the prediction is equally crucial as predicting the survival rate of cancer patients, which has become a key issue of cancer research.

VGG-COVIDNet: A Novel model for COVID detection from X-Ray and CT Scan images.

In this research work, a new deep learning model named VGG-COVIDNet has been proposed which can classify COVID-19 cases from normal cases over X-Rays and CT scan images of lungs. Medical practitioners use the X-Rays and CT scan images of lungs to identify whether a person is infected from COVID or not. In present times, it is very important to give real time COVID prediction with high reliability of results.

The Role of Body Appreciation in the Decision to Complete Metabolic and Bariatric Surgery Among Ethnically Diverse Patients.

Purpose: Metabolic and bariatric surgery (MBS) is an evidence-based safe, effective treatment for obesity. However, only half of referred or eligible persons complete the procedure for unknown reasons. The proposed study examined the association between the degree of body appreciation and the decision to complete MBS by ethnicity.

Association Between Patient Satisfaction With Their Patient-Physician Relationship and Completion of Bariatric Surgery by Race and Ethnicity Among US Adults.

Importance: Metabolic and bariatric surgery (MBS) is an effective and safe treatment for obesity and its comorbidities, but less than 50% of those who are eligible and referred for MBS complete the procedure. The patient-physician relationship could be a decisive factor in the decision to complete MBS; however, this relationship has not been explored, particularly among racially and ethnically diverse populations.

Objective: To examine the association between patient-reported satisfaction with their patient-physician relationship and MBS completion by self-reported racial and ethnic group.

Academic Health Centers and Humanitarian Crises: One Health System's Response to Unaccompanied Children at the Border.

University of California Health (UCH) provided a system-wide, rapid response to the humanitarian crisis of unaccompanied children crossing the southern U.S. border in the midst of the COVID-19 pandemic in 2021.

Re-administration of SmallPox vaccine against MonkeyPox among general population; after more 30 Years of vaccine cessation by WHO.

Monkeypox virus, Orthopoxvirus of the Poxviridae family which was first isolated from pox lesions of monkeys, hence named monkeypox Fever, rash, and enlarged lymph nodes are common symptoms, but it can also lead to a variety of medical complications, including secondary infections, bronchopneumonia, sepsis, encephalitis, and corneal infection with vision loss. The current outbreak doesn't follow previous pattern of transmission through animals but person to person transmission. We highlight several studies including WHO stats for protective role of small pox vaccine and recommend potential strategies for current and future disease eliminations.

Extra-Axial Cystic Meningioma without Dural Attachment in an Adult: Case Report and Review of Literature.

Intraparenchymal meningiomas, meningiomas without dural attachment, and cystic meningioma are atypical and extremely rare, especially in adults. Only four cases of intraparenchymal cystic meningioma without dural attachment have been reported. A 47-year-old female presented with an altered sensorium.

Delivering Electives the Clerkship Way: Consolidating the Student Doctor Method of Training.

Student doctor method of clinical training or clinical clerkship provides students with exposure to the entire longitudinal illness of the patient. The students participate in patient care as a part of treating team and can refine their clinical, communication and procedural skills. It provides them with an opportunity to work with the faculty and experience the future workplace.

Changes in body weight, health behaviors, and mental health in adults with obesity during the COVID-19 pandemic.

Objective: The aim of this study was to examine the relationships between body weight changes, health behaviors, and mental health in adults with obesity during the second year of the COVID-19 pandemic.

Methods: Between March 1, 2021, and November 30, 2021, adults from three obesity practices completed an online survey. The primary outcomes were ≥ 5% of body weight change since March 2020 and associated health behaviors and mental health factors.