Selective Cytotoxicity of Medical Cannabis ( L.) Extracts Across the Whole Vegetation Cycle Under Various Hydroponic and Nutritional Treatments.

The use of L. in health care requires stringent care for the optimal production of the bioactive compounds. However, plant phenotypes and the content of secondary metabolites, such as phytocannabinoids, are strongly influenced by external factors, such as nutrient availability.

Circulating proteolytic products of carboxypeptidase N for early detection of breast cancer.

Background: Carboxypeptidase N (CPN) is important in regulating vasoactive peptide hormones, growth factors, and cytokines by specifically cleaving their C-terminal basic residues. We investigated whether circulating peptides specifically cleaved by CPN in the tumor microenvironment can be stage-specific indicators of breast cancer.

Methods: CPN activity was measured using an ex vivo peptide cleavage assay by incubating synthesized C3f peptide (His6-C3f_S1304-R1320-His6) in interstitial fluids of breast tumors and adjacent normal breast tissues in mice with orthotopic implantation of the human cell line MDA-MB-231.

[Long-term results of the surgical treatment of parasagittal meningiomas].

The article analyses the late results of surgical treatment of 123 patients with parasagittal meningiomas of various localization along the superior sagittal sinus (SSS) and falx cerebri (FC). Invalidism of patients after operations for meningiomas of the middle third of the sagittal line is still high because of stable motor defects. The results of operations for SSS resection without restoration of venous outflow of the hemisphere are poorer.

[Rehabilitative therapy after removal of parasagittal meningiomas].

A complex of restorative treatment measures applied for promoting the process of motor function restoration in patients who underwent removal of parasagittal meningiomas includes drug therapy, physiotherapy, and therapeutic exercises. The lapse of time after the operation and the specific features of the motor defect must be taken into account. The suggested complex was used in 87 patients.

[Disorders of motor functions after removal of parasagittal meningiomas].

Specific features of motor activity disorders were studied in 87 patients before and after removal of a parasagittal meningioma. Motor disorders are most severe in localization of the tumor in the region of the middle third of the superior sagittal sinus and falx and less severe when the tumor is found in the posterior parts of the anterior third of the superior sagittal sinus. The disorders are more marked after operation with extensive resection of areas of the superior sagittal sinus involves in the tumor and with occlusion of the formed venous drainage passages.

[Radiation-induced meningiomas of the brain].

From the observation over 62 patients with meningioma of the brain a connection was detected between previous X-ray irradiation of the skin on the head and the occurrence of the meningioma. Predominance of parasagittal localization of the tumors was revealed which, evidently, was associated with the peculiarities of the method of X-ray therapy applied and with the possibility of the growth of the meningiomas from arachnoid-endothelial aggregations in the dura mater. Multiple meningiomas were encountered in 23% of the patients.

[Complex study of the hemodynamics, impedance, and bioelectrical activity of the brain of patients with parasagittal meningiomas].

Combined use of radioisotope and impedance methods in the examination of cerebral and peripheral circulation and EEG recording in 40 patients with parasagittal meningiomas revealed a correlation between the rheographic characteristics of the tonus and blood filling of the cerebral vessels and the quantitative values of cerebral hemodynamics. Specific features of cerebral circulatory disorders characteristic of parasagittal tumors were revealed before operation and in the postoperative period. The prognostic significance of examination of the cerebral blood flow and impedance in the early postoperative period is demonstrated.