Publications by authors named "Kukkala K Kumar"
Yeast lipid has gained prominence as a sustainable energy source and so various oleaginous yeasts are being investigated to create efficient lipogenic platforms. This review aims to assess the various biotechnological strategies for enhanced production of yeast lipids via agro-waste processing and media engineering including multiomic analyses, genetic engineering, random mutagenesis, and laboratory adaptive evolution. The review also emphasizes the role of cutting-edge omics technologies in pinpointing differentially expressed genes and enriched networks crucial for designing advanced metabolic engineering strategies for prominent oleaginous yeast species.
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- - Diabetes mellitus, particularly type 2 diabetes (T2DM), is a chronic condition that disrupts metabolism and is becoming increasingly common worldwide, primarily due to issues with insulin production and function.
- - Genetic and epigenetic factors contribute significantly to T2DM, with enzymes called histone deacetylases (HDACs) playing key roles in insulin release, glucose metabolism, and various regulatory processes that affect diabetes progression.
- - This review discusses the function of HDACs in T2DM, the potential of HDAC inhibitors (HDACi) as biomarkers and therapeutic targets, and their promising role in improving insulin sensitivity and protecting pancreatic β-cells.
Article Synopsis
- - Proper growth and branching of dendrites are essential for the central nervous system's functioning, as they influence how information is processed in the brain.
- - The development of dendrites is regulated by both intrinsic cellular programs and various extrinsic factors, including neurotransmitters and proteins in the extracellular environment.
- - The response of dendrites to these extracellular signals can vary, leading to either growth promotion or limitation, and is influenced by factors such as receptor type, developmental stages, and species differences.
Oleaginous yeast has great biotechnological potential and scientific interest, yet the molecular rationale of its cellular behavior to carbon and nitrogen ratios with concurrent lipid agglomeration remains elusive. Here, metabolomics adaptations of the in response to varying glucose and nitrogen concentrations have been investigated. In preliminary screening we found that 5% glucose (/) was optimal for further analysis in 3641.
View Article and Find Full Text PDFPlasmodial resistance to a variety of plant-based antimalarial drugs has led toward the discovery of more effective antimalarial compounds having chemical or biological origin. Since natural compounds are considered as safer drugs, in this study, yeast strains were identified and compared for the production of carotenoids that are well-known antioxidants and this metabolite was tested for its antiparasitic activity. Plasmodium falciparum 3D7 strain was selected as the target parasite for evaluation of antimalarial activity of yeast carotenoids using in vitro studies.
View Article and Find Full Text PDFBackground: To meet the present transportation demands and solve food versus fuel issue, microbial lipid-derived biofuels are gaining attention worldwide. This study is focussed on high-throughput screening of oleaginous yeast by microwave-aided Nile red spectrofluorimetry and exploring pongamia shell hydrolysate (PSH) as a feedstock for lipid production using novel oleaginous yeast INDKK.
Results: A new oleaginous yeast INDKK was identified and selected for microbial lipid production.