[A course of chronic glomerulonephritis and constitutional features].

Aim: To evaluate correlations between the course of chronic glomerulonephritis (CG) and the patients' constitution.

Material And Methods: 30 men and 33 women with chronic CG were divided into four groups: group 1--chronic latent GN, group 2--chronic nephrotic GN without renal failure, group 3--chronic mixed GN including rapidly progressive GN, group 4--chronic GN with renal failure. Constitution fell into 3 standard types of diathesis: dyscrasic (DD), arthritic (AD), psoric (PD).

[Clinical varieties of chronic glomerulonephritis and psychic characteristics of patients].

Aim: To clarify correlations between clinical variants of chronic glomerulonephritis (CGN) and psychic status of CGN patients.

Material And Methods: 10 patients with latent nephritis, 17 patients with nephrotic nephritis, 8 patients with mixed nephritis and 7 patients with rapidly progressive nephritis have undergone clinical and psychic examination both in the disease exacerbation and remission.

Results: No significant correlations were found between the severity of CGN and severity of mental disorders though it was noticed that with deterioration of CGN the rate of mental deviations grows.

[Course of chronic hepatitis B and C and constitutional characteristics of the patients].

The relationship between hepatitis course and constitution assessed by the signs of 3 major diatheses (dyscrasic--DD. arthritic--AD and psoriatic--PD) was studied in 41 patients with HBV infection (low active-25 patients, moderate activity-6 patients, cirrhosis-10 patients) and 62 patients with NCV infection (low active-23, moderate-13, cirrhosis-26). In both infections domination of DD over AD and PD was associated with more severe course of the disease while Ad domination over DD and PD indicated a mild course.

[The course of peptic ulcer in relation to patients' constitution].

Sixty one patients with peptic ulcer (PU) were examined to assess the specific features of its condition in relation to their affiliation to the type of morphological constitution (diathesis). Patients with PU were found to have most commonly dyscrasic diathesis. With predominant dyscrasic diathesis, there were more frequently complications of PU (rough scarring deformations of the gastric or duodenal walls, ulcer bleeding, perforation without clear association with the advance of PU, patient compliance, and the adequacy of antiulcerous therapy.

[Treatment of bone disorders in renal diseases].

Aim: To study possible correction of bone disorders (osteopenia, Ca/P-imbalance, bone pain, limited volume of indolent movements) which are still a serious complication associated with renal diseases and pathogenic therapy (steroids).

Materials And Methods: The bone disorders were treated in 10 uremic hemodialyzed patients (8 men, 2 women; group 1) with vitamin D3 (calcitriol made in Russia) + rhEPO (recormon; Boehringer Mannheim), in 15 patients (15 women, 0 men) with lupus-nephritis (group 2) with vitamin D3 (n = 5, group 2a) or miscalcic (Sandoz) (n = 10, group 2b), in 2 patients (2 men, 0 women) with glomerulonephritis (group 3) with vitamin D3 + miacalcic. Additionally all the patients received Ca salts.

[Azoospermia in patients with kidney diseases taking immunosuppressants long term].

Ten sterile males of reproductive age previously treated with immunodepressants were examined andrologically. Azoospermia in them was treated with zinc sulfate (30-90 mg/day, 2-12 months), which was replaced by clomifen citrate in 6 of them (100 mg/day, 2-6.6 months).

[The efficacy of an erythropoietin-calcitriol combination in patients with chronic kidney failure on programmed hemodialysis].

In 8 patients with chronic renal failure (CRF) on hemodialysis combined therapy (erythropoietin+calcitriol) effect was evaluated versus control group of 9 hemodialysis patients on erythropoietin monotherapy. In patients on the combined regimen the antianemic effect occurred sooner, this effect of calcitriol coming prior to correction of uremic defects in phosphoric-calcium metabolism. Calcitriol mechanisms of action in renal anemia and benefits of potential calcitriol+erythropoietin combination use in CRF patients suffering from uremic osteodystrophy, hypercatabolic conditions, uremic hypogonadism and infection complications are discussed.

[Calcitriol: role in the regulation of erythropoiesis, use in the treatment of renal anemia].

The efficiency of combined therapy (erythropoietin + calcitriol) used in 8 patients with chronic renal failure on programmed hemodialysis was comparatively evaluated with erythropoietin monotherapy employed in 9 patients with the same disease on hemodialysis which represented a control group. The anti-anemia effect was achieved on the average of 5 weeks earlier in the group of patients given the combined therapy than that in the controls. The differences between the two groups were statistically significant in the rate of anti-anemia effect achievement.

[The endocrine status of men with lupus nephritis].

Renal function was assessed in 8 males at reproductive age suffering from lupus nephritis (LN). Normal renal function was registered in 5 patients, hypofunction in 3 males. Endocrinological examinations (evaluation of secondary sexual characters, of hypophyseal and sex hormone profile, sexological questionnaires, spermograms) failed to distinguish significant differences between SLE males and renal patients without SLE suffering from hypogonadism (13 males with uremic hypogonadism, 10 males with azoospermia induced by cytostatics).

[Nephropathy-related disorders of physical and sexual development in girls: experience with successful stimulation by zinc, parlodel and norcolut].

The paper reports 3 cases of physical and sexual retardation in girls aged 14-22 with nephropathy: 1 girl had uremia in a conservative stage, 1 patient was put on a chronic hemodialysis for terminal uremia, 1 girl received a renal transplant. In response to combined treatment (zinc sulfate+parlodel) in the former two patients and norcolute therapy in the latter one body mass and growth increased in all the 3. The discussion is concerned with mechanisms of developmental defects in nephropathies, comparative efficacy of the drugs used and social rehabilitation of nephropathy girls with small height and sexual infantilism.

[Pathospermia in patients with glomerulonephritis and rheumatoid arthritis treated by immunodepressants: the possibilities of its correction with zinc and parlodel].

Two groups of patients aged 16.5-31 years with pathospermia given immunodepressants (IDS) for glomerulonephritis (group I) or rheumatoid arthritis (group II) before and/or at the moment of examination were examined. Five out of 6 patients of group I and all the patients of group II showed azoospermia.

[The effect of treatment with human recombinant erythropoietin on the functional status of patients on maintenance hemodialysis].

As many as ten patients with terminal uremia on maintenance hemodialysis (MH) performed from 11 to 52 months (28 +/- 4 on the average) were treated with recombinant human erythropoietin (rhERP) manufactured by Cilag (Switzerland). The preparation was injected i.v.

[Zinc and parlodel: the treatment potentials for retardation of growth and sexual development in nephropathies in adolescents].

Ten adolescents aged 10-18 years with physical and/or sexual development retardation associated with nephropathy were examined. Eight patients were treated with immunodepressants before and/or at the moment of examination. The difference between the age indicated in the patient's passport and bone age ranged within 0 to 3 years.

[Zinc in the treatment of hypogonadism in patients with renal pathology].

The relationship of the symptoms of hypogonadism (HG) with the serum level (SL) of zinc was investigated in 31 uremic male patients: 16 on hemodialysis (I group), 10 on a low-protein diet (II group), and 5 kidney graft recipients (III group). A conclusion has been made that in renal pathology a zinc SL does not always reflect the content of zinc in the body however zinc acetate therapy is effective in the treatment of HG patients as well as in the treatment of retarded physical and sexual development in adolescents with nephropathies.

[Current possibilities of correction of hormonal imbalance in uremia].

The authors' and literature data on hormonal imbalance in uremia are analysed. The pathogenesis, clinical and laboratory signs and present-day methods of correction of renal osteodystrophy, anemia, arterial hypertension, derangements of carbohydrate and lipid metabolism, and hypogonadism developing as complications of chronic renal insufficiency (CRI), are considered. Increased potentialities of pharmacological correction of the above endocrine disturbances in CRI have been shown.

Parlodel treatment of uremic hypogonadism in men.

Parlodel, 2.5 mg daily, was given during 1-3 months to 14 uremic hypogonadal patients (placebo controlled in 6). Except for a decrease in serum prolactin levels on Parlodel (p less than 0.