Publications by authors named "Kui-Lin Fei"
Article Synopsis
- Preeclampsia (PE) is a major cause of maternal and fetal death globally, and the study identifies the long non-coding RNA HOTAIR as a significant factor involved in PE.
- Researchers utilized various assays to show that HOTAIR is up-regulated in PE tissues and negatively affects trophoblast cell functions like proliferation, migration, and invasion by repressing the expression of miR-106a.
- The findings suggest that HOTAIR interacts with the epigenetic repressor EZH2 to inhibit miR-106a, highlighting the potential of targeting these molecules for future PE treatments.
MicroRNA‑21 (miR‑21) is reported to exhibit cancer‑promoting activity in various types of cancer. It has been previously demonstrated that miR‑21 is overexpressed in bladder tumor tissue compared with normal mucosa. However, the functional mechanism of miR‑21 in bladder cancer remains largely unknown.
View Article and Find Full Text PDFThe neuromedin B receptor (Nmbr) is an important physiological regulator of spontaneous activities and stress responses through different cascades as well as its autocrine and paracrine effects. Previous studies have revealed that neuromedin B (Nmb) and its receptor signal via the Rela (also known as p65)/Il6 pathway in a mouse model of pregnancy. This study investigated the mechanism of Nmbr signaling via the Rela/p65-Il6 pathway and regulation of the concentration of intracellular free calcium ([Ca(2+)](i)) during the onset of labor in primary mouse myometrial cell cultures isolated from mice in term labor.
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